TopFIND 4.0

Q86Y97: Histone-lysine N-methyltransferase KMT5C {ECO:0000305}

General Information

Protein names
- Histone-lysine N-methyltransferase KMT5C {ECO:0000305}
- 2.1.1.43
- Lysine N-methyltransferase 5C
- Lysine-specific methyltransferase 5C {ECO:0000312|HGNC:HGNC:28405}
- Suppressor of variegation 4-20 homolog 2
- Su(var)4-20 homolog 2
- Suv4-20h2
Gene names SUV420H2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q86Y97

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGPDRVTARE LCENDDLATS LVLDPYLGFR THKMNVSPVP PLRRQQHLRS ALETFLRQRD 
        70         80         90        100        110        120 
LEAAYRALTL GGWTARYFQS RGPRQEAALK THVYRYLRAF LPESGFTILP CTRYSMETNG 
       130        140        150        160        170        180 
AKIVSTRAWK KNEKLELLVG CIAELREADE GLLRAGENDF SIMYSTRKRS AQLWLGPAAF 
       190        200        210        220        230        240 
INHDCKPNCK FVPADGNAAC VKVLRDIEPG DEVTCFYGEG FFGEKNEHCE CHTCERKGEG 
       250        260        270        280        290        300 
AFRTRPREPA LPPRPLDKYQ LRETKRRLQQ GLDSGSRQGL LGPRACVHPS PLRRDPFCAA 
       310        320        330        340        350        360 
CQPLRLPACS ARPDTSPLWL QWLPQPQPRV RPRKRRRPRP RRAPVLSTHH AARVSLHRWG 
       370        380        390        400        410        420 
GCGPHCRLRG EALVALGQPP HARWAPQQDW HWARRYGLPY VVRVDLRRLA PAPPATPAPA 
       430        440        450        460    
GTPGPILIPK QALAFAPFSP PKRLRLVVSH GSIDLDVGGE EL

Isoforms

- Isoform 2 of Histone-lysine N-methyltransferase SUV420H2 - Isoform 2 of Histone-lysine N-methyltransferase KMT5C

Sequence View

        10         20         30         40         50         60 
MGPDRVTARE LCENDDLATS LVLDPYLGFR THKMNVSPVP PLRRQQHLRS ALETFLRQRD 
        70         80         90        100        110        120 
LEAAYRALTL GGWTARYFQS RGPRQEAALK THVYRYLRAF LPESGFTILP CTRYSMETNG 
       130        140        150        160        170        180 
AKIVSTRAWK KNEKLELLVG CIAELREADE GLLRAGENDF SIMYSTRKRS AQLWLGPAAF 
       190        200        210        220        230        240 
INHDCKPNCK FVPADGNAAC VKVLRDIEPG DEVTCFYGEG FFGEKNEHCE CHTCERKGEG 
       250        260        270        280        290        300 
AFRTRPREPA LPPRPLDKYQ LRETKRRLQQ GLDSGSRQGL LGPRACVHPS PLRRDPFCAA 
       310        320        330        340        350        360 
CQPLRLPACS ARPDTSPLWL QWLPQPQPRV RPRKRRRPRP RRAPVLSTHH AARVSLHRWG 
       370        380        390        400        410        420 
GCGPHCRLRG EALVALGQPP HARWAPQQDW HWARRYGLPY VVRVDLRRLA PAPPATPAPA 
       430        440        450        460    
GTPGPILIPK QALAFAPFSP PKRLRLVVSH GSIDLDVGGE EL         10         20         30         40         50         60 
MGPDRVTARE LCENDDLATS LVLDPYLGFR THKMNVSPVP PLRRQQHLRS ALETFLRQRD 
        70         80         90        100        110        120 
LEAAYRALTL GGWTARYFQS RGPRQEAALK THVYRYLRAF LPESGFTILP CTRYSMETNG 
       130        140        150        160        170        180 
AKIVSTRAWK KNEKLELLVG CIAELREADE GLLRAGENDF SIMYSTRKRS AQLWLGPAAF 
       190        200        210        220        230        240 
INHDCKPNCK FVPADGNAAC VKVLRDIEPG DEVTCFYGEG FFGEKNEHCE CHTCERKGEG 
       250        260        270        280        290        300 
AFRTRPREPA LPPRPLDKYQ LRETKRRLQQ GLDSGSRQGL LGPRACVHPS PLRRDPFCAA 
       310        320        330        340        350        360 
CQPLRLPACS ARPDTSPLWL QWLPQPQPRV RPRKRRRPRP RRAPVLSTHH AARVSLHRWG 
       370        380        390        400        410        420 
GCGPHCRLRG EALVALGQPP HARWAPQQDW HWARRYGLPY VVRVDLRRLA PAPPATPAPA 
       430        440        450        460    
GTPGPILIPK QALAFAPFSP PKRLRLVVSH GSIDLDVGGE EL



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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q86Y97-1-unknown MGPDRV... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q86Y97-1-unknown MGPDRV... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt91128

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...GGEEL 462 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)