TopFIND 4.0

Q86YW0: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

General Information

Protein names
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
- 3.1.4.11
- Phosphoinositide phospholipase C-zeta-1
- Phospholipase C-zeta-1 {ECO:0000303|PubMed:12416999}
- PLC-zeta-1 {ECO:0000303|PubMed:12416999}
- Testis-development protein NYD-SP27
Gene names PLCZ1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q86YW0

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MEMRWFLSKI QDDFRGGKIN LEKTQRLLEK LDIRCSYIHV KQIFKDNDRL KQGRITIEEF 
        70         80         90        100        110        120 
RAIYRIITHR EEIIEIFNTY SENRKILLAS NLAQFLTQEQ YAAEMSKAIA FEIIQKYEPI 
       130        140        150        160        170        180 
EEVRKAHQMS LEGFTRYMDS RECLLFKNEC RKVYQDMTHP LNDYFISSSH NTYLVSDQLL 
       190        200        210        220        230        240 
GPSDLWGYVS ALVKGCRCLE IDCWDGAQNE PVVYHGYTLT SKLLFKTVIQ AIHKYAFMTS 
       250        260        270        280        290        300 
DYPVVLSLEN HCSTAQQEVM ADNLQATFGE SLLSDMLDDF PDTLPSPEAL KFKILVKNKK 
       310        320        330        340        350        360 
IGTLKETHER KGSDKRGDNQ DKETGVKKLP GVMLFKKKKT RKLKIALALS DLVIYTKAEK 
       370        380        390        400        410        420 
FKSFQHSRLY QQFNENNSIG ETQARKLSKL RVHEFIFHTR KFITRIYPKA TRADSSNFNP 
       430        440        450        460        470        480 
QEFWNIGCQM VALNFQTPGL PMDLQNGKFL DNGGSGYILK PHFLRESKSY FNPSNIKEGM 
       490        500        510        520        530        540 
PITLTIRLIS GIQLPLTHSS SNKGDSLVII EVFGVPNDQM KQQTRVIKKN AFSPRWNETF 
       550        560        570        580        590        600 
TFIIHVPELA LIRFVVEGQG LIAGNEFLGQ YTLPLLCMNK GYRRIPLFSR MGESLEPASL 
   
FVYVWYVR

Isoforms

- Isoform 2 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 - Isoform 3 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

Sequence View

        10         20         30         40         50         60 
MEMRWFLSKI QDDFRGGKIN LEKTQRLLEK LDIRCSYIHV KQIFKDNDRL KQGRITIEEF 
        70         80         90        100        110        120 
RAIYRIITHR EEIIEIFNTY SENRKILLAS NLAQFLTQEQ YAAEMSKAIA FEIIQKYEPI 
       130        140        150        160        170        180 
EEVRKAHQMS LEGFTRYMDS RECLLFKNEC RKVYQDMTHP LNDYFISSSH NTYLVSDQLL 
       190        200        210        220        230        240 
GPSDLWGYVS ALVKGCRCLE IDCWDGAQNE PVVYHGYTLT SKLLFKTVIQ AIHKYAFMTS 
       250        260        270        280        290        300 
DYPVVLSLEN HCSTAQQEVM ADNLQATFGE SLLSDMLDDF PDTLPSPEAL KFKILVKNKK 
       310        320        330        340        350        360 
IGTLKETHER KGSDKRGDNQ DKETGVKKLP GVMLFKKKKT RKLKIALALS DLVIYTKAEK 
       370        380        390        400        410        420 
FKSFQHSRLY QQFNENNSIG ETQARKLSKL RVHEFIFHTR KFITRIYPKA TRADSSNFNP 
       430        440        450        460        470        480 
QEFWNIGCQM VALNFQTPGL PMDLQNGKFL DNGGSGYILK PHFLRESKSY FNPSNIKEGM 
       490        500        510        520        530        540 
PITLTIRLIS GIQLPLTHSS SNKGDSLVII EVFGVPNDQM KQQTRVIKKN AFSPRWNETF 
       550        560        570        580        590        600 
TFIIHVPELA LIRFVVEGQG LIAGNEFLGQ YTLPLLCMNK GYRRIPLFSR MGESLEPASL 
   
FVYVWYVR         10         20         30         40         50         60 
MEMRWFLSKI QDDFRGGKIN LEKTQRLLEK LDIRCSYIHV KQIFKDNDRL KQGRITIEEF 
        70         80         90        100        110        120 
RAIYRIITHR EEIIEIFNTY SENRKILLAS NLAQFLTQEQ YAAEMSKAIA FEIIQKYEPI 
       130        140        150        160        170        180 
EEVRKAHQMS LEGFTRYMDS RECLLFKNEC RKVYQDMTHP LNDYFISSSH NTYLVSDQLL 
       190        200        210        220        230        240 
GPSDLWGYVS ALVKGCRCLE IDCWDGAQNE PVVYHGYTLT SKLLFKTVIQ AIHKYAFMTS 
       250        260        270        280        290        300 
DYPVVLSLEN HCSTAQQEVM ADNLQATFGE SLLSDMLDDF PDTLPSPEAL KFKILVKNKK 
       310        320        330        340        350        360 
IGTLKETHER KGSDKRGDNQ DKETGVKKLP GVMLFKKKKT RKLKIALALS DLVIYTKAEK 
       370        380        390        400        410        420 
FKSFQHSRLY QQFNENNSIG ETQARKLSKL RVHEFIFHTR KFITRIYPKA TRADSSNFNP 
       430        440        450        460        470        480 
QEFWNIGCQM VALNFQTPGL PMDLQNGKFL DNGGSGYILK PHFLRESKSY FNPSNIKEGM 
       490        500        510        520        530        540 
PITLTIRLIS GIQLPLTHSS SNKGDSLVII EVFGVPNDQM KQQTRVIKKN AFSPRWNETF 
       550        560        570        580        590        600 
TFIIHVPELA LIRFVVEGQG LIAGNEFLGQ YTLPLLCMNK GYRRIPLFSR MGESLEPASL 
   
FVYVWYVR



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Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q86YW0-1-unknown MEMRWF... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q86YW0-1-unknown MEMRWF... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt85517
    Q86YW0-105-unknown MSKAIA... 105 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt85518

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)