TopFIND 4.0

Q8BG58: Transmembrane prolyl 4-hydroxylase

General Information

Protein names
- Transmembrane prolyl 4-hydroxylase
- P4H-TM
- 1.14.11.29 {ECO:0000250|UniProtKB:Q9NXG6}
- Hypoxia-inducible factor prolyl hydroxylase 4
- HIF-PH4
- HIF-prolyl hydroxylase 4
- HPH-4
Gene names P4htm
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q8BG58

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAAAVATVQR PEAETVEEAS NLQWPLPPEH RPSGAATRPG DSEDAPVRPL CKPRGICSRA 
        70         80         90        100        110        120 
YFLVLMVFVH LYLGNVLALL LFVHYSNGDE STDPGPQRRE QSPQPVPTLG PLTRLEGIKV 
       130        140        150        160        170        180 
GYERKVQVVA GRDHFIRTLS LKPLLFEIPG FLSDEECRLI IHLAQMKGLQ RSQILPTEEY 
       190        200        210        220        230        240 
EEAMSAMQVS QLDLFQLLDQ NHDGRLQLRE VLAQTRLGNG RWMTPENIQE MYSAIKADPD 
       250        260        270        280        290        300 
GDGVLSLQEF SNMDLRDFHK YMRSHKAESN ELVRNSHHTW LHQGEGAHHV MRAIRQRVLR 
       310        320        330        340        350        360 
LTRLSPEIVE FSEPLQVVRY GEGGHYHAHV DSGPVYPETI CSHTKLVANE SVPFETSCRY 
       370        380        390        400        410        420 
MTVLFYLNNV TGGGETVFPV ADNRTYDEMS LIQDDVDLRD TRRHCDKGNL RVKPQQGTAV 
       430        440        450        460        470        480 
FWYNYLPDGQ GWVGEVDDYS LHGGCLVTRG TKWIANNWIN VDPSRARQAL FQQEMARLAR 
       490        500    
EGGMDSQPEW ALDRAYSDAR VEL

Isoforms

- Isoform 2 of Transmembrane prolyl 4-hydroxylase

Sequence View

        10         20         30         40         50         60 
MAAAVATVQR PEAETVEEAS NLQWPLPPEH RPSGAATRPG DSEDAPVRPL CKPRGICSRA 
        70         80         90        100        110        120 
YFLVLMVFVH LYLGNVLALL LFVHYSNGDE STDPGPQRRE QSPQPVPTLG PLTRLEGIKV 
       130        140        150        160        170        180 
GYERKVQVVA GRDHFIRTLS LKPLLFEIPG FLSDEECRLI IHLAQMKGLQ RSQILPTEEY 
       190        200        210        220        230        240 
EEAMSAMQVS QLDLFQLLDQ NHDGRLQLRE VLAQTRLGNG RWMTPENIQE MYSAIKADPD 
       250        260        270        280        290        300 
GDGVLSLQEF SNMDLRDFHK YMRSHKAESN ELVRNSHHTW LHQGEGAHHV MRAIRQRVLR 
       310        320        330        340        350        360 
LTRLSPEIVE FSEPLQVVRY GEGGHYHAHV DSGPVYPETI CSHTKLVANE SVPFETSCRY 
       370        380        390        400        410        420 
MTVLFYLNNV TGGGETVFPV ADNRTYDEMS LIQDDVDLRD TRRHCDKGNL RVKPQQGTAV 
       430        440        450        460        470        480 
FWYNYLPDGQ GWVGEVDDYS LHGGCLVTRG TKWIANNWIN VDPSRARQAL FQQEMARLAR 
       490        500    
EGGMDSQPEW ALDRAYSDAR VEL



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8BG58-1-unknown MAAAVA... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8BG58-1-unknown MAAAVA... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt84051

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...ARVEL 503 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)