TopFIND 4.0

Q8BGW1: Alpha-ketoglutarate-dependent dioxygenase FTO {ECO:0000305}

General Information

Protein names
- Alpha-ketoglutarate-dependent dioxygenase FTO {ECO:0000305}
- Fat mass and obesity-associated protein {ECO:0000303|PubMed:17991826}
- Protein fatso {ECO:0000303|PubMed:10501967}
- U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO {ECO:0000305}
- 1.14.11.- {ECO:0000250|UniProtKB:Q9C0B1}
- U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO {ECO:0000305}
- 1.14.11.- {ECO:0000250|UniProtKB:Q9C0B1}
- mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO {ECO:0000305}
- m6A(m)-demethylase FTO {ECO:0000305}
- 1.14.11.- {ECO:0000250|UniProtKB:Q9C0B1}
- mRNA N(6)-methyladenosine demethylase FTO {ECO:0000305}
- 1.14.11.53 {ECO:0000305|PubMed:23817550}
- tRNA N1-methyl adenine demethylase FTO {ECO:0000305}
- 1.14.11.- {ECO:0000250|UniProtKB:Q9C0B1}
Gene names Fto
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q8BGW1

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MKRVQTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLV FREAGSIPEE 
        70         80         90        100        110        120 
LHKEVPEAFL TLHKHGCLFR DVVRIQGKDV LTPVSRILIG DPGCTYKYLN TRLFTVPWPV 
       130        140        150        160        170        180 
KGCTVKYTEA EIAAACQTFL KLNDYLQVET IQALEELAVR EKANEDAVPL CMAEFPRAGV 
       190        200        210        220        230        240 
GPSCDDEVDL KSRAAYNVTL LNFMDPQKMP YLKEEPYFGM GKMAVSWHHD ENLVDRSAVA 
       250        260        270        280        290        300 
VYSYSCEGSE DESEDESSFE GRDPDTWHVG FKISWDIETP GLTIPLHQGD CYFMLDDLNA 
       310        320        330        340        350        360 
THQHCVLAGS QPRFSSTHRV AECSTGTLDY ILERCQLALQ NVLNDSDDGD VSLKSFDPAV 
       370        380        390        400        410        420 
LKQGEEIHNE VEFEWLRQFW FQGNRYKLCT DWWCEPMTHL EGLWKKMESM TNAVLREVKR 
       430        440        450        460        470        480 
EGLPVEQRSE ILSAILVPLT VRQNLRKEWH ARCQSRVVRT LPVQQKPDCR PYWEKDDPSM 
       490        500    
PLPFDLTDVV SELRGQLLEA RS

Isoforms

- Isoform 2 of Alpha-ketoglutarate-dependent dioxygenase FTO - Isoform 3 of Alpha-ketoglutarate-dependent dioxygenase FTO - Isoform 4 of Alpha-ketoglutarate-dependent dioxygenase FTO

Sequence View

        10         20         30         40         50         60 
MKRVQTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLV FREAGSIPEE 
        70         80         90        100        110        120 
LHKEVPEAFL TLHKHGCLFR DVVRIQGKDV LTPVSRILIG DPGCTYKYLN TRLFTVPWPV 
       130        140        150        160        170        180 
KGCTVKYTEA EIAAACQTFL KLNDYLQVET IQALEELAVR EKANEDAVPL CMAEFPRAGV 
       190        200        210        220        230        240 
GPSCDDEVDL KSRAAYNVTL LNFMDPQKMP YLKEEPYFGM GKMAVSWHHD ENLVDRSAVA 
       250        260        270        280        290        300 
VYSYSCEGSE DESEDESSFE GRDPDTWHVG FKISWDIETP GLTIPLHQGD CYFMLDDLNA 
       310        320        330        340        350        360 
THQHCVLAGS QPRFSSTHRV AECSTGTLDY ILERCQLALQ NVLNDSDDGD VSLKSFDPAV 
       370        380        390        400        410        420 
LKQGEEIHNE VEFEWLRQFW FQGNRYKLCT DWWCEPMTHL EGLWKKMESM TNAVLREVKR 
       430        440        450        460        470        480 
EGLPVEQRSE ILSAILVPLT VRQNLRKEWH ARCQSRVVRT LPVQQKPDCR PYWEKDDPSM 
       490        500    
PLPFDLTDVV SELRGQLLEA RS         10         20         30         40         50         60 
MKRVQTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLV FREAGSIPEE 
        70         80         90        100        110        120 
LHKEVPEAFL TLHKHGCLFR DVVRIQGKDV LTPVSRILIG DPGCTYKYLN TRLFTVPWPV 
       130        140        150        160        170        180 
KGCTVKYTEA EIAAACQTFL KLNDYLQVET IQALEELAVR EKANEDAVPL CMAEFPRAGV 
       190        200        210        220        230        240 
GPSCDDEVDL KSRAAYNVTL LNFMDPQKMP YLKEEPYFGM GKMAVSWHHD ENLVDRSAVA 
       250        260        270        280        290        300 
VYSYSCEGSE DESEDESSFE GRDPDTWHVG FKISWDIETP GLTIPLHQGD CYFMLDDLNA 
       310        320        330        340        350        360 
THQHCVLAGS QPRFSSTHRV AECSTGTLDY ILERCQLALQ NVLNDSDDGD VSLKSFDPAV 
       370        380        390        400        410        420 
LKQGEEIHNE VEFEWLRQFW FQGNRYKLCT DWWCEPMTHL EGLWKKMESM TNAVLREVKR 
       430        440        450        460        470        480 
EGLPVEQRSE ILSAILVPLT VRQNLRKEWH ARCQSRVVRT LPVQQKPDCR PYWEKDDPSM 
       490        500    
PLPFDLTDVV SELRGQLLEA RS         10         20         30         40         50         60 
MKRVQTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLV FREAGSIPEE 
        70         80         90        100        110        120 
LHKEVPEAFL TLHKHGCLFR DVVRIQGKDV LTPVSRILIG DPGCTYKYLN TRLFTVPWPV 
       130        140        150        160        170        180 
KGCTVKYTEA EIAAACQTFL KLNDYLQVET IQALEELAVR EKANEDAVPL CMAEFPRAGV 
       190        200        210        220        230        240 
GPSCDDEVDL KSRAAYNVTL LNFMDPQKMP YLKEEPYFGM GKMAVSWHHD ENLVDRSAVA 
       250        260        270        280        290        300 
VYSYSCEGSE DESEDESSFE GRDPDTWHVG FKISWDIETP GLTIPLHQGD CYFMLDDLNA 
       310        320        330        340        350        360 
THQHCVLAGS QPRFSSTHRV AECSTGTLDY ILERCQLALQ NVLNDSDDGD VSLKSFDPAV 
       370        380        390        400        410        420 
LKQGEEIHNE VEFEWLRQFW FQGNRYKLCT DWWCEPMTHL EGLWKKMESM TNAVLREVKR 
       430        440        450        460        470        480 
EGLPVEQRSE ILSAILVPLT VRQNLRKEWH ARCQSRVVRT LPVQQKPDCR PYWEKDDPSM 
       490        500    
PLPFDLTDVV SELRGQLLEA RS



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LEARS 502 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)