TopFIND 4.0

Q8BI55: Dual specificity tyrosine-phosphorylation-regulated kinase 4

General Information

Protein names
- Dual specificity tyrosine-phosphorylation-regulated kinase 4
- 2.7.12.1
Gene names Dyrk4
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q8BI55

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MQLLRLPALT RTETSMDTNK ARKRSLTTFP ILKARKKQSF TSVKVESKPL GHLQKPSSKN 
        70         80         90        100        110        120 
KKLRVNRCPQ KIPSNTAFPF VDTKGKRNTV NFPQIGNKVP SKGPMQYQEN QIHNQVLSSE 
       130        140        150        160        170        180 
LKTSEIPFNI NTKAQDTKPH PELQKKHKVP LTVAEALKFF KNQLSPYEQS EILGYSELWF 
       190        200        210        220        230        240 
LGLEAKKLNV VPEKFSKTSF DDEHGSYMKV LHDHIAYRYE VLEMIGKGSF GQVAKCLDHK 
       250        260        270        280        290        300 
NNELVALKII RNKKRFHHQA LVELKILEAL RRKDKDNNHN VVHMKDFFYF RNHLCITFEL 
       310        320        330        340        350        360 
LGINLYELMK NNSFHGFNLS IVRRFTFSIL KCLHMLYVEK IIHCDLKPEN IVLYQRGQVT 
       370        380        390        400        410        420 
VKVIDFGSSC YEHQKVYTYI QSRFYRSPEV ILGHPYNMAI DMWSLGCIMA ELYTGYPLFP 
       430        440        450        460        470        480 
GENEVEQLAC IMEVLGLPPA HFTQTASRRQ VFFDSKGLPK NINNNRGGKR YPDSKDLTMV 
       490        500        510        520        530        540 
VKTYDSSFLD FLRRCLVWEP SLRMTPEQAL KHAWIHEPRK FKPRPKPQIL RKPGASISSE 
       550        560        570        580        590        600 
ISTEKAEEQQ ASKGKKDEAT KETTDKLKDE AEKHLENSGK QQSSVEHTAD TIQLPHLTEA 
       610        620        630    
SGKSETVAGS EMSAEQQSTS SPKSTNILPP IV

Isoforms

- Isoform 2 of Dual specificity tyrosine-phosphorylation-regulated kinase 4

Sequence View

        10         20         30         40         50         60 
MQLLRLPALT RTETSMDTNK ARKRSLTTFP ILKARKKQSF TSVKVESKPL GHLQKPSSKN 
        70         80         90        100        110        120 
KKLRVNRCPQ KIPSNTAFPF VDTKGKRNTV NFPQIGNKVP SKGPMQYQEN QIHNQVLSSE 
       130        140        150        160        170        180 
LKTSEIPFNI NTKAQDTKPH PELQKKHKVP LTVAEALKFF KNQLSPYEQS EILGYSELWF 
       190        200        210        220        230        240 
LGLEAKKLNV VPEKFSKTSF DDEHGSYMKV LHDHIAYRYE VLEMIGKGSF GQVAKCLDHK 
       250        260        270        280        290        300 
NNELVALKII RNKKRFHHQA LVELKILEAL RRKDKDNNHN VVHMKDFFYF RNHLCITFEL 
       310        320        330        340        350        360 
LGINLYELMK NNSFHGFNLS IVRRFTFSIL KCLHMLYVEK IIHCDLKPEN IVLYQRGQVT 
       370        380        390        400        410        420 
VKVIDFGSSC YEHQKVYTYI QSRFYRSPEV ILGHPYNMAI DMWSLGCIMA ELYTGYPLFP 
       430        440        450        460        470        480 
GENEVEQLAC IMEVLGLPPA HFTQTASRRQ VFFDSKGLPK NINNNRGGKR YPDSKDLTMV 
       490        500        510        520        530        540 
VKTYDSSFLD FLRRCLVWEP SLRMTPEQAL KHAWIHEPRK FKPRPKPQIL RKPGASISSE 
       550        560        570        580        590        600 
ISTEKAEEQQ ASKGKKDEAT KETTDKLKDE AEKHLENSGK QQSSVEHTAD TIQLPHLTEA 
       610        620        630    
SGKSETVAGS EMSAEQQSTS SPKSTNILPP IV



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Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8BI55-1-unknown MQLLRL... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LPPIV 632 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...LPPIV 632 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt69068

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)