Q8BYW1: Rho GTPase-activating protein 25

General Information

Protein names	- Rho GTPase-activating protein 25 - Rho-type GTPase-activating protein 25
Gene names	Arhgap25
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8BYW1

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Rho GTPase-activating protein 25 - Isoform 3 of Rho GTPase-activating protein 25

Sequence View

        10         20         30         40         50         60
MSLKLPRNWD FNLKAEASKI ARSRSVMTGE QMAAFHPPTT PNPLERPIKV GWLKKQRSIV
        70         80         90        100        110        120
KNWQQRYFVL RAQQLYYYKD EEDSKPQGCM YLPGSTVKEI ATNPEEAGKF VFEVIPASSD
       130        140        150        160        170        180
QNRIGQDSYV LMASSQVEME EWVKFLRRVA GTPSGAVFGQ RLDETVAYEQ KFGPHLVPIL
       190        200        210        220        230        240
VEKCAEFILE HGVSEEGIFR LPGQDNLVKQ LRDAFDAGER PSFDRDTDVH TVASLLKLYL
       250        260        270        280        290        300
RDLPEPVVPW SQYEGFLLCG QLMNADEAKA QQELVKQLST LPRDNYNLLS YICRFLHEIQ
       310        320        330        340        350        360
LNCAVNKMSV DNLATVIGVN LIRSKVEDPA VIMRGTPQIQ RVMTMMIRDH EVLFPKSKDA
       370        380        390        400        410        420
PISPPAQKND AKKAPVPRSS VGWDATEDPP LSRTDSFSNT ASSPDATSPT GPLPSDQHQE
       430        440        450        460        470        480
DSGKAPRENP GDWKMQSRKR TQTLPNRKCF LTSAFQGTTS SKLEIFKNEF WSPSSEAKAG
       490        500        510        520        530        540
EGHRRTMSQD LRHLSNDQRT STYDNVPTSP QSQGNPAGAL SPPASDSKRD ALVSTDSEME
       550        560        570        580        590        600
AGSKNSGEDD LDSLQRTVQS LQKEIETQKQ VYEEQIKNLE KENYDVWAKV VRLNEELERE
       610        620        630        640
RKKFAALEIS LRNVERSRED VEKRNRVLEE EVKEFVKSME KPKTKTDP         10         20         30         40         50         60
MSLKLPRNWD FNLKAEASKI ARSRSVMTGE QMAAFHPPTT PNPLERPIKV GWLKKQRSIV
        70         80         90        100        110        120
KNWQQRYFVL RAQQLYYYKD EEDSKPQGCM YLPGSTVKEI ATNPEEAGKF VFEVIPASSD
       130        140        150        160        170        180
QNRIGQDSYV LMASSQVEME EWVKFLRRVA GTPSGAVFGQ RLDETVAYEQ KFGPHLVPIL
       190        200        210        220        230        240
VEKCAEFILE HGVSEEGIFR LPGQDNLVKQ LRDAFDAGER PSFDRDTDVH TVASLLKLYL
       250        260        270        280        290        300
RDLPEPVVPW SQYEGFLLCG QLMNADEAKA QQELVKQLST LPRDNYNLLS YICRFLHEIQ
       310        320        330        340        350        360
LNCAVNKMSV DNLATVIGVN LIRSKVEDPA VIMRGTPQIQ RVMTMMIRDH EVLFPKSKDA
       370        380        390        400        410        420
PISPPAQKND AKKAPVPRSS VGWDATEDPP LSRTDSFSNT ASSPDATSPT GPLPSDQHQE
       430        440        450        460        470        480
DSGKAPRENP GDWKMQSRKR TQTLPNRKCF LTSAFQGTTS SKLEIFKNEF WSPSSEAKAG
       490        500        510        520        530        540
EGHRRTMSQD LRHLSNDQRT STYDNVPTSP QSQGNPAGAL SPPASDSKRD ALVSTDSEME
       550        560        570        580        590        600
AGSKNSGEDD LDSLQRTVQS LQKEIETQKQ VYEEQIKNLE KENYDVWAKV VRLNEELERE
       610        620        630        640
RKKFAALEIS LRNVERSRED VEKRNRVLEE EVKEFVKSME KPKTKTDP

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q8BYW1-1-unknown	MSLKLP...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8BYW1-12-unknown	NLKAEA...	12	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30756
Q8BYW1-14-unknown	KAEASK...	14	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30757
Q8BYW1-27-unknown	MTGEQM...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt87658
Q8BYW1-90-unknown	MYLPGS...	90	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt87657
Q8BYW1-90-unknown	MYLPGS...	90	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101893
Q8BYW1-314-unknown	ATVIGV...	314	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30758
Q8BYW1-314-unknown	ATVIGV...	314	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147539
Q8BYW1-314-unknown	ATVIGV...	314	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149544

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RNWDFN	11	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30756
...WDFNLK	13	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30757
...SVDNLA	313	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30758
...SVDNLA	313	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130890
...SVDNLA	313	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132928
...TKTDP	648	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TKTDP	648	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83275
...TKTDP	648	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83276

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Evidence name
CATE_MOUSE	11	WDFN.\|.NLKA	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> RHG25_MOUSE @11
CATE_MOUSE	13	FNLK.\|.KAEA	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> RHG25_MOUSE @13
CATE_MOUSE	313	DNLA.\|.ATVI	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> RHG25_MOUSE @313

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)