TopFIND 4.0

Q8C3P7: N6-adenosine-methyltransferase subunit METTL3

General Information

Protein names
- N6-adenosine-methyltransferase subunit METTL3
- 2.1.1.348 {ECO:0000269|PubMed:24394384}
- Methyltransferase-like protein 3
- N6-adenosine-methyltransferase 70 kDa subunit
- MT-A70
Gene names Mettl3
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q8C3P7

3

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSDTWSSIQA HKKQLDSLRE RLQRRRKQDS GHLDLRNPEA ALSPTFRSDS PVPTAPTSSG 
        70         80         90        100        110        120 
PKPSTTSVAP ELATDPELEK KLLHHLSDLA LTLPTDAVSI RLAISTPDAP ATQDGVESLL 
       130        140        150        160        170        180 
QKFAAQELIE VKRGLLQDDA HPTLVTYADH SKLSAMMGAV ADKKGLGEVA GTIAGQKRRA 
       190        200        210        220        230        240 
EQDLTTVTTF ASSLASGLAS SASEPAKEPA KKSRKHAASD VDLEIESLLN QQSTKEQQSK 
       250        260        270        280        290        300 
KVSQEILELL NTTTAKEQSI VEKFRSRGRA QVQEFCDYGT KEECMKASDA DRPCRKLHFR 
       310        320        330        340        350        360 
RIINKHTDES LGDCSFLNTC FHMDTCKYVH YEIDACVDSE SPGSKEHMPS QELALTQSVG 
       370        380        390        400        410        420 
GDSSADRLFP PQWICCDIRY LDVSILGKFA VVMADPPWDI HMELPYGTLT DDEMRRLNIP 
       430        440        450        460        470        480 
VLQDDGFLFL WVTGRAMELG RECLNLWGYE RVDEIIWVKT NQLQRIIRTG RTGHWLNHGK 
       490        500        510        520        530        540 
EHCLVGVKGN PQGFNQGLDC DVIVAEVRST SHKPDEIYGM IERLSPGTRK IELFGRPHNV 
       550        560        570        580    
QPNWITLGNQ LDGIHLLDPD VVARFKQRYP DGIISKPKNL 

Isoforms

- Isoform 2 of N6-adenosine-methyltransferase subunit METTL3

Sequence View

        10         20         30         40         50         60 
MSDTWSSIQA HKKQLDSLRE RLQRRRKQDS GHLDLRNPEA ALSPTFRSDS PVPTAPTSSG 
        70         80         90        100        110        120 
PKPSTTSVAP ELATDPELEK KLLHHLSDLA LTLPTDAVSI RLAISTPDAP ATQDGVESLL 
       130        140        150        160        170        180 
QKFAAQELIE VKRGLLQDDA HPTLVTYADH SKLSAMMGAV ADKKGLGEVA GTIAGQKRRA 
       190        200        210        220        230        240 
EQDLTTVTTF ASSLASGLAS SASEPAKEPA KKSRKHAASD VDLEIESLLN QQSTKEQQSK 
       250        260        270        280        290        300 
KVSQEILELL NTTTAKEQSI VEKFRSRGRA QVQEFCDYGT KEECMKASDA DRPCRKLHFR 
       310        320        330        340        350        360 
RIINKHTDES LGDCSFLNTC FHMDTCKYVH YEIDACVDSE SPGSKEHMPS QELALTQSVG 
       370        380        390        400        410        420 
GDSSADRLFP PQWICCDIRY LDVSILGKFA VVMADPPWDI HMELPYGTLT DDEMRRLNIP 
       430        440        450        460        470        480 
VLQDDGFLFL WVTGRAMELG RECLNLWGYE RVDEIIWVKT NQLQRIIRTG RTGHWLNHGK 
       490        500        510        520        530        540 
EHCLVGVKGN PQGFNQGLDC DVIVAEVRST SHKPDEIYGM IERLSPGTRK IELFGRPHNV 
       550        560        570        580    
QPNWITLGNQ LDGIHLLDPD VVARFKQRYP DGIISKPKNL 



Filter Information:


(REFRESH)

Directness:


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Evidence Codes:


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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)