TopFIND 4.0

Q8C4Y3: Negative elongation factor B

General Information

Protein names
- Negative elongation factor B
- NELF-B
- Cofactor of BRCA1 {ECO:0000303|PubMed:19340312}
Gene names Nelfb
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q8C4Y3

1

N-termini

3

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MFAGLQDLGV ANGEDLKETL TNCTEPLKAI EQFQTENGVL LPSLQSALPF LDLHGTPRLE 
        70         80         90        100        110        120 
FHQSVFDELR DKLLERVSAI ASEGKAEERY KKLEDLLEKS FSLVKMPSLQ PVVMCVMKHL 
       130        140        150        160        170        180 
PKVPEKKLKL VMADKELYRA CAVEVKRQIW QDNQALFGDE VSPLLKQYIL EKESALFSTE 
       190        200        210        220        230        240 
LSVLHNFFSP SPKTRRQGEV VQKLTQMVGK NVKLYDMVLQ FLRTLFLRTR NVHYCTLRAE 
       250        260        270        280        290        300 
LLMSLHDLDV SDICTVDPCH KFTWCLDACI RERFVDSKRA RELQGFLDGV KKGQEQVLGD 
       310        320        330        340        350        360 
LSMILCDPFA INTLSLSTIR HLQELVSQET LPRDSPDLLL LLRLLALGQG AWDLIDSQVF 
       370        380        390        400        410        420 
KEPKMEAELI TKFLPMLMSL VVDDFTFNVD QKLPAEEKAS VTYPNTLPES FTKFLQEQRM 
       430        440        450        460        470        480 
ACEVGLYYVL HITKQRNKNA LLRLLPGLVE TFGDLAFSDI FLHLLTGSLV LLADEFALED 
       490        500        510        520        530        540 
FCSSLFDGFF LTASPRKENV HRHVLRLLLH LHARVAPSKL EALQKALEPT GQSGEAVKEL 
       550        560        570        580    
YSQLGEKLEQ LDHRKPSPTQ AAETPALDLP LPSVPAPATL 

Isoforms

- Isoform 2 of Negative elongation factor B

Sequence View

        10         20         30         40         50         60 
MFAGLQDLGV ANGEDLKETL TNCTEPLKAI EQFQTENGVL LPSLQSALPF LDLHGTPRLE 
        70         80         90        100        110        120 
FHQSVFDELR DKLLERVSAI ASEGKAEERY KKLEDLLEKS FSLVKMPSLQ PVVMCVMKHL 
       130        140        150        160        170        180 
PKVPEKKLKL VMADKELYRA CAVEVKRQIW QDNQALFGDE VSPLLKQYIL EKESALFSTE 
       190        200        210        220        230        240 
LSVLHNFFSP SPKTRRQGEV VQKLTQMVGK NVKLYDMVLQ FLRTLFLRTR NVHYCTLRAE 
       250        260        270        280        290        300 
LLMSLHDLDV SDICTVDPCH KFTWCLDACI RERFVDSKRA RELQGFLDGV KKGQEQVLGD 
       310        320        330        340        350        360 
LSMILCDPFA INTLSLSTIR HLQELVSQET LPRDSPDLLL LLRLLALGQG AWDLIDSQVF 
       370        380        390        400        410        420 
KEPKMEAELI TKFLPMLMSL VVDDFTFNVD QKLPAEEKAS VTYPNTLPES FTKFLQEQRM 
       430        440        450        460        470        480 
ACEVGLYYVL HITKQRNKNA LLRLLPGLVE TFGDLAFSDI FLHLLTGSLV LLADEFALED 
       490        500        510        520        530        540 
FCSSLFDGFF LTASPRKENV HRHVLRLLLH LHARVAPSKL EALQKALEPT GQSGEAVKEL 
       550        560        570        580    
YSQLGEKLEQ LDHRKPSPTQ AAETPALDLP LPSVPAPATL 



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Evidence Codes:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8C4Y3-1-unknown MFAGLQ... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)