TopFIND 4.0

Q8C7N7: Gamma-secretase subunit APH-1B

General Information

Protein names
- Gamma-secretase subunit APH-1B
- APH-1b
- Aph-1beta
Gene names Aph1b
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q8C7N7

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MTAAVFFGCA FIAFGPALAL YVFTIATDPL RVIFLIAGAF FWLVSLLLSS VFWFLVRVIT 
        70         80         90        100        110        120 
DNRDGPVQNY LLIFGVLLSV CIQELFRLAY YKLLKKASEG LKSINPEETA PSMRLLAYVS 
       130        140        150        160        170        180 
GLGFGIMSGV FSFVNTLSNS LGPGTVGIHG DSPQFFLNSA FMTLVVIMLH VFWGVVFFDG 
       190        200        210        220        230        240 
CEKNKWYTLL TVLLTHLVVS TQTFLSPYYE VNLVTAYIIM VLMGIWAFYV AGGSCRSLKL 
       250    
CLLCQDKDFL LYNQRSR

Isoforms

- Isoform 2 of Gamma-secretase subunit APH-1B

Sequence View

        10         20         30         40         50         60 
MTAAVFFGCA FIAFGPALAL YVFTIATDPL RVIFLIAGAF FWLVSLLLSS VFWFLVRVIT 
        70         80         90        100        110        120 
DNRDGPVQNY LLIFGVLLSV CIQELFRLAY YKLLKKASEG LKSINPEETA PSMRLLAYVS 
       130        140        150        160        170        180 
GLGFGIMSGV FSFVNTLSNS LGPGTVGIHG DSPQFFLNSA FMTLVVIMLH VFWGVVFFDG 
       190        200        210        220        230        240 
CEKNKWYTLL TVLLTHLVVS TQTFLSPYYE VNLVTAYIIM VLMGIWAFYV AGGSCRSLKL 
       250    
CLLCQDKDFL LYNQRSR



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8C7N7-1-unknown MTAAVF... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8C7N7-1-unknown MTAAVF... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt67225

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...NQRSR 257 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)