Q8C878: NEDD8-activating enzyme E1 catalytic subunit

General Information

Protein names	- NEDD8-activating enzyme E1 catalytic subunit - 6.2.1.- - NEDD8-activating enzyme E1C - Ubiquitin-activating enzyme E1C - Ubiquitin-like modifier-activating enzyme 3 - Ubiquitin-activating enzyme 3
Gene names	Uba3
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8C878

6 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADGEEPEKK RRRIEELLAE KMAVDGGCGD TGDWEGRWNH VKKFLERSGP FTHPDFEPST
        70         80         90        100        110        120
ESLQFLLDTC KVLVIGAGGL GCELLKNLAL SGFRQIHVID MDTIDVSNLN RQFLFRPKDV
       130        140        150        160        170        180
GRPKAEVAAE FLNDRVPNCN VVPHFNKIQD FNDTFYRQFH IIVCGLDSII ARRWINGMLI
       190        200        210        220        230        240
SLLNYEDGVL DPSSIVPLID GGTEGFKGNA RVILPGMTAC IECTLELYPP QVNFPMCTIA
       250        260        270        280        290        300
SMPRLPEHCI EYVRMLQWPK EQPFGDGVPL DGDDPEHIQW IFQKSIERAS QYNIRGVTYR
       310        320        330        340        350        360
LTQGVVKRII PAVASTNAVI AAVCATEVFK IATSAYIPLN NYLVFNDVDG LYTYTFEAER
       370        380        390        400        410        420
KENCPACSQL PQNIQFSPSA KLQEVLDYLT NSASLQMKSP AITATLEGKN RTLYLQSVTS
       430        440        450        460
IEERTRPNLS KTLKELGLVD GQELAVADVT TPQTVLFKLH FT

Isoforms

- Isoform 2 of NEDD8-activating enzyme E1 catalytic subunit

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q8C878-1-unknown	MADGEE...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt93568
Q8C878-2-unknown	MADGEE...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q8C878-2-unknown	MADGEE...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8C878-2-Acetylation	ADGEEP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8C878-2-Acetylation	ADGEEP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110354
Q8C878-2-Acetylation	ADGEEP...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q8C878-22-unknown	MAVDGG...	22		inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q8C878-22-unknown	MAVDGG...	22		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195276
Q8C878-102-unknown	DTIDVS...	102		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30777
Q8C878-102-unknown	DTIDVS...	102		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142493
Q8C878-152-unknown	NDTFYR...	152		inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q8C878-152-unknown	NDTFYR...	152		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197647

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HVIDMD	101	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30777
...HVIDMD	101	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125688
...NSASLQ	395	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89186
...KLHFT	462	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	101	IDMD.\|.DTID	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> UBA3_MOUSE @101

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)