Q8CE90: Dual specificity mitogen-activated protein kinase kinase 7

General Information

Protein names	- Dual specificity mitogen-activated protein kinase kinase 7 - MAP kinase kinase 7 - MAPKK 7 - 2.7.12.2 - JNK-activating kinase 2 - MAPK/ERK kinase 7 - MEK 7 - c-Jun N-terminal kinase kinase 2 - JNK kinase 2 - JNKK 2
Gene names	Map2k7
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8CE90

4 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Dual specificity mitogen-activated protein kinase kinase 7 - Isoform 3 of Dual specificity mitogen-activated protein kinase kinase 7 - Isoform 4 of Dual specificity mitogen-activated protein kinase kinase 7 - Isoform 5 of Dual specificity mitogen-activated protein kinase kinase 7 - Isoform 6 of Dual specificity mitogen-activated protein kinase kinase 7 - Isoform 7 of Dual specificity mitogen-activated protein kinase kinase 7 - Isoform 8 of Dual specificity mitogen-activated protein kinase kinase 7 - Isoform 3 of Dual specificity mitogen-activated protein kinase kinase 7 - Isoform 4 of Dual specificity mitogen-activated protein kinase kinase 7 - Isoform 5 of Dual specificity mitogen-activated protein kinase kinase 7

Sequence View

        10         20         30         40         50         60
MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PIIVITLSPA PAPSQRAALQ
        70         80         90        100        110        120
LPLANDGGSR SPSSESSPQH PTPPTRPRHM LGLPSTLFTP RSMESIEIDQ KLQEIMKQTG
       130        140        150        160        170        180
YLTIGGQRYQ AEINDLENLG EMGSGTCGQV WKMRFRKTGH IIAVKQMRRS GNKEENKRIL
       190        200        210        220        230        240
MDLDVVLKSH DCPYIVQCFG TFITNTDVFI AMELMGTCAE KLKKRMQGPI PERILGKMTV
       250        260        270        280        290        300
AIVKALYYLK EKHGVIHRDV KPSNILLDER GQIKLCDFGI SGRLVDSKAK TRSAGCAAYM
       310        320        330        340        350        360
APERIDPPDP TKPDYDIRAD VWSLGISLVE LATGQFPYKN CKTDFEVLTK VLQEEPPLLP
       370        380        390        400        410        420
GHMGFSGDFQ SFVKDCLTKD HRKRPKYNKL LEHSFIKHYE ILEVDVASWF KDVMAKTESP
       430        440        450        460        470        480
RTSGVLSQHH LPFFSTSVTW GAWPLAAQTP FQSGVIRCRG RVPSPRRATG GSGGQPCVCA
       490        500        510        520        530
GGPGPSFTEM GPSPSPMLSN TFFTPDPGAC PGASTWGLPR RRLCQLLTTS TPGCC         10         20         30         40         50         60
MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PIIVITLSPA PAPSQRAALQ
        70         80         90        100        110        120
LPLANDGGSR SPSSESSPQH PTPPTRPRHM LGLPSTLFTP RSMESIEIDQ KLQEIMKQTG
       130        140        150        160        170        180
YLTIGGQRYQ AEINDLENLG EMGSGTCGQV WKMRFRKTGH IIAVKQMRRS GNKEENKRIL
       190        200        210        220        230        240
MDLDVVLKSH DCPYIVQCFG TFITNTDVFI AMELMGTCAE KLKKRMQGPI PERILGKMTV
       250        260        270        280        290        300
AIVKALYYLK EKHGVIHRDV KPSNILLDER GQIKLCDFGI SGRLVDSKAK TRSAGCAAYM
       310        320        330        340        350        360
APERIDPPDP TKPDYDIRAD VWSLGISLVE LATGQFPYKN CKTDFEVLTK VLQEEPPLLP
       370        380        390        400        410        420
GHMGFSGDFQ SFVKDCLTKD HRKRPKYNKL LEHSFIKHYE ILEVDVASWF KDVMAKTESP
       430        440        450        460        470        480
RTSGVLSQHH LPFFSTSVTW GAWPLAAQTP FQSGVIRCRG RVPSPRRATG GSGGQPCVCA
       490        500        510        520        530
GGPGPSFTEM GPSPSPMLSN TFFTPDPGAC PGASTWGLPR RRLCQLLTTS TPGCC         10         20         30         40         50         60
MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PIIVITLSPA PAPSQRAALQ
        70         80         90        100        110        120
LPLANDGGSR SPSSESSPQH PTPPTRPRHM LGLPSTLFTP RSMESIEIDQ KLQEIMKQTG
       130        140        150        160        170        180
YLTIGGQRYQ AEINDLENLG EMGSGTCGQV WKMRFRKTGH IIAVKQMRRS GNKEENKRIL
       190        200        210        220        230        240
MDLDVVLKSH DCPYIVQCFG TFITNTDVFI AMELMGTCAE KLKKRMQGPI PERILGKMTV
       250        260        270        280        290        300
AIVKALYYLK EKHGVIHRDV KPSNILLDER GQIKLCDFGI SGRLVDSKAK TRSAGCAAYM
       310        320        330        340        350        360
APERIDPPDP TKPDYDIRAD VWSLGISLVE LATGQFPYKN CKTDFEVLTK VLQEEPPLLP
       370        380        390        400        410        420
GHMGFSGDFQ SFVKDCLTKD HRKRPKYNKL LEHSFIKHYE ILEVDVASWF KDVMAKTESP
       430        440        450        460        470        480
RTSGVLSQHH LPFFSTSVTW GAWPLAAQTP FQSGVIRCRG RVPSPRRATG GSGGQPCVCA
       490        500        510        520        530
GGPGPSFTEM GPSPSPMLSN TFFTPDPGAC PGASTWGLPR RRLCQLLTTS TPGCC         10         20         30         40         50         60
MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PIIVITLSPA PAPSQRAALQ
        70         80         90        100        110        120
LPLANDGGSR SPSSESSPQH PTPPTRPRHM LGLPSTLFTP RSMESIEIDQ KLQEIMKQTG
       130        140        150        160        170        180
YLTIGGQRYQ AEINDLENLG EMGSGTCGQV WKMRFRKTGH IIAVKQMRRS GNKEENKRIL
       190        200        210        220        230        240
MDLDVVLKSH DCPYIVQCFG TFITNTDVFI AMELMGTCAE KLKKRMQGPI PERILGKMTV
       250        260        270        280        290        300
AIVKALYYLK EKHGVIHRDV KPSNILLDER GQIKLCDFGI SGRLVDSKAK TRSAGCAAYM
       310        320        330        340        350        360
APERIDPPDP TKPDYDIRAD VWSLGISLVE LATGQFPYKN CKTDFEVLTK VLQEEPPLLP
       370        380        390        400        410        420
GHMGFSGDFQ SFVKDCLTKD HRKRPKYNKL LEHSFIKHYE ILEVDVASWF KDVMAKTESP
       430        440        450        460        470        480
RTSGVLSQHH LPFFSTSVTW GAWPLAAQTP FQSGVIRCRG RVPSPRRATG GSGGQPCVCA
       490        500        510        520        530
GGPGPSFTEM GPSPSPMLSN TFFTPDPGAC PGASTWGLPR RRLCQLLTTS TPGCC         10         20         30         40         50         60
MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PIIVITLSPA PAPSQRAALQ
        70         80         90        100        110        120
LPLANDGGSR SPSSESSPQH PTPPTRPRHM LGLPSTLFTP RSMESIEIDQ KLQEIMKQTG
       130        140        150        160        170        180
YLTIGGQRYQ AEINDLENLG EMGSGTCGQV WKMRFRKTGH IIAVKQMRRS GNKEENKRIL
       190        200        210        220        230        240
MDLDVVLKSH DCPYIVQCFG TFITNTDVFI AMELMGTCAE KLKKRMQGPI PERILGKMTV
       250        260        270        280        290        300
AIVKALYYLK EKHGVIHRDV KPSNILLDER GQIKLCDFGI SGRLVDSKAK TRSAGCAAYM
       310        320        330        340        350        360
APERIDPPDP TKPDYDIRAD VWSLGISLVE LATGQFPYKN CKTDFEVLTK VLQEEPPLLP
       370        380        390        400        410        420
GHMGFSGDFQ SFVKDCLTKD HRKRPKYNKL LEHSFIKHYE ILEVDVASWF KDVMAKTESP
       430        440        450        460        470        480
RTSGVLSQHH LPFFSTSVTW GAWPLAAQTP FQSGVIRCRG RVPSPRRATG GSGGQPCVCA
       490        500        510        520        530
GGPGPSFTEM GPSPSPMLSN TFFTPDPGAC PGASTWGLPR RRLCQLLTTS TPGCC         10         20         30         40         50         60
MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PIIVITLSPA PAPSQRAALQ
        70         80         90        100        110        120
LPLANDGGSR SPSSESSPQH PTPPTRPRHM LGLPSTLFTP RSMESIEIDQ KLQEIMKQTG
       130        140        150        160        170        180
YLTIGGQRYQ AEINDLENLG EMGSGTCGQV WKMRFRKTGH IIAVKQMRRS GNKEENKRIL
       190        200        210        220        230        240
MDLDVVLKSH DCPYIVQCFG TFITNTDVFI AMELMGTCAE KLKKRMQGPI PERILGKMTV
       250        260        270        280        290        300
AIVKALYYLK EKHGVIHRDV KPSNILLDER GQIKLCDFGI SGRLVDSKAK TRSAGCAAYM
       310        320        330        340        350        360
APERIDPPDP TKPDYDIRAD VWSLGISLVE LATGQFPYKN CKTDFEVLTK VLQEEPPLLP
       370        380        390        400        410        420
GHMGFSGDFQ SFVKDCLTKD HRKRPKYNKL LEHSFIKHYE ILEVDVASWF KDVMAKTESP
       430        440        450        460        470        480
RTSGVLSQHH LPFFSTSVTW GAWPLAAQTP FQSGVIRCRG RVPSPRRATG GSGGQPCVCA
       490        500        510        520        530
GGPGPSFTEM GPSPSPMLSN TFFTPDPGAC PGASTWGLPR RRLCQLLTTS TPGCC         10         20         30         40         50         60
MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PIIVITLSPA PAPSQRAALQ
        70         80         90        100        110        120
LPLANDGGSR SPSSESSPQH PTPPTRPRHM LGLPSTLFTP RSMESIEIDQ KLQEIMKQTG
       130        140        150        160        170        180
YLTIGGQRYQ AEINDLENLG EMGSGTCGQV WKMRFRKTGH IIAVKQMRRS GNKEENKRIL
       190        200        210        220        230        240
MDLDVVLKSH DCPYIVQCFG TFITNTDVFI AMELMGTCAE KLKKRMQGPI PERILGKMTV
       250        260        270        280        290        300
AIVKALYYLK EKHGVIHRDV KPSNILLDER GQIKLCDFGI SGRLVDSKAK TRSAGCAAYM
       310        320        330        340        350        360
APERIDPPDP TKPDYDIRAD VWSLGISLVE LATGQFPYKN CKTDFEVLTK VLQEEPPLLP
       370        380        390        400        410        420
GHMGFSGDFQ SFVKDCLTKD HRKRPKYNKL LEHSFIKHYE ILEVDVASWF KDVMAKTESP
       430        440        450        460        470        480
RTSGVLSQHH LPFFSTSVTW GAWPLAAQTP FQSGVIRCRG RVPSPRRATG GSGGQPCVCA
       490        500        510        520        530
GGPGPSFTEM GPSPSPMLSN TFFTPDPGAC PGASTWGLPR RRLCQLLTTS TPGCC         10         20         30         40         50         60
MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PIIVITLSPA PAPSQRAALQ
        70         80         90        100        110        120
LPLANDGGSR SPSSESSPQH PTPPTRPRHM LGLPSTLFTP RSMESIEIDQ KLQEIMKQTG
       130        140        150        160        170        180
YLTIGGQRYQ AEINDLENLG EMGSGTCGQV WKMRFRKTGH IIAVKQMRRS GNKEENKRIL
       190        200        210        220        230        240
MDLDVVLKSH DCPYIVQCFG TFITNTDVFI AMELMGTCAE KLKKRMQGPI PERILGKMTV
       250        260        270        280        290        300
AIVKALYYLK EKHGVIHRDV KPSNILLDER GQIKLCDFGI SGRLVDSKAK TRSAGCAAYM
       310        320        330        340        350        360
APERIDPPDP TKPDYDIRAD VWSLGISLVE LATGQFPYKN CKTDFEVLTK VLQEEPPLLP
       370        380        390        400        410        420
GHMGFSGDFQ SFVKDCLTKD HRKRPKYNKL LEHSFIKHYE ILEVDVASWF KDVMAKTESP
       430        440        450        460        470        480
RTSGVLSQHH LPFFSTSVTW GAWPLAAQTP FQSGVIRCRG RVPSPRRATG GSGGQPCVCA
       490        500        510        520        530
GGPGPSFTEM GPSPSPMLSN TFFTPDPGAC PGASTWGLPR RRLCQLLTTS TPGCC         10         20         30         40         50         60
MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PIIVITLSPA PAPSQRAALQ
        70         80         90        100        110        120
LPLANDGGSR SPSSESSPQH PTPPTRPRHM LGLPSTLFTP RSMESIEIDQ KLQEIMKQTG
       130        140        150        160        170        180
YLTIGGQRYQ AEINDLENLG EMGSGTCGQV WKMRFRKTGH IIAVKQMRRS GNKEENKRIL
       190        200        210        220        230        240
MDLDVVLKSH DCPYIVQCFG TFITNTDVFI AMELMGTCAE KLKKRMQGPI PERILGKMTV
       250        260        270        280        290        300
AIVKALYYLK EKHGVIHRDV KPSNILLDER GQIKLCDFGI SGRLVDSKAK TRSAGCAAYM
       310        320        330        340        350        360
APERIDPPDP TKPDYDIRAD VWSLGISLVE LATGQFPYKN CKTDFEVLTK VLQEEPPLLP
       370        380        390        400        410        420
GHMGFSGDFQ SFVKDCLTKD HRKRPKYNKL LEHSFIKHYE ILEVDVASWF KDVMAKTESP
       430        440        450        460        470        480
RTSGVLSQHH LPFFSTSVTW GAWPLAAQTP FQSGVIRCRG RVPSPRRATG GSGGQPCVCA
       490        500        510        520        530
GGPGPSFTEM GPSPSPMLSN TFFTPDPGAC PGASTWGLPR RRLCQLLTTS TPGCC         10         20         30         40         50         60
MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PIIVITLSPA PAPSQRAALQ
        70         80         90        100        110        120
LPLANDGGSR SPSSESSPQH PTPPTRPRHM LGLPSTLFTP RSMESIEIDQ KLQEIMKQTG
       130        140        150        160        170        180
YLTIGGQRYQ AEINDLENLG EMGSGTCGQV WKMRFRKTGH IIAVKQMRRS GNKEENKRIL
       190        200        210        220        230        240
MDLDVVLKSH DCPYIVQCFG TFITNTDVFI AMELMGTCAE KLKKRMQGPI PERILGKMTV
       250        260        270        280        290        300
AIVKALYYLK EKHGVIHRDV KPSNILLDER GQIKLCDFGI SGRLVDSKAK TRSAGCAAYM
       310        320        330        340        350        360
APERIDPPDP TKPDYDIRAD VWSLGISLVE LATGQFPYKN CKTDFEVLTK VLQEEPPLLP
       370        380        390        400        410        420
GHMGFSGDFQ SFVKDCLTKD HRKRPKYNKL LEHSFIKHYE ILEVDVASWF KDVMAKTESP
       430        440        450        460        470        480
RTSGVLSQHH LPFFSTSVTW GAWPLAAQTP FQSGVIRCRG RVPSPRRATG GSGGQPCVCA
       490        500        510        520        530
GGPGPSFTEM GPSPSPMLSN TFFTPDPGAC PGASTWGLPR RRLCQLLTTS TPGCC

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q8CE90-2-unknown	MAASSL...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q8CE90-2-unknown	MAASSL...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8CE90-1-unknown	MAASSL...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81439
Q8CE90-1-unknown	MAASSL...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81443
Q8CE90-1-unknown	MAASSL...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81444
Q8CE90-1-unknown	MAASSL...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81445
Q8CE90-2-Acetylation	AASSLE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8CE90-2-Acetylation	AASSLE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110540
Q8CE90-2-Acetylation	AASSLE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110541
Q8CE90-2-Acetylation	AASSLE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110542
Q8CE90-2-Acetylation	AASSLE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110543
Q8CE90-2-Acetylation	AASSLE...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q8CE90-90-unknown	MLGLPS...	90		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000106622
Q8CE90-90-unknown	MLGLPS...	90		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000106623
Q8CE90-90-unknown	MLGLPS...	90		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196794
Q8CE90-90-unknown	MLGLPS...	90		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196795
Q8CE90-90-unknown	MLGLPS...	90		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196793
Q8CE90-90-unknown	MLGLPS...	90		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196790
Q8CE90-90-unknown	MLGLPS...	90		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196796
Q8CE90-90-unknown	MLGLPS...	90		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196791
Q8CE90-90-unknown	MLGLPS...	90		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196792

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...TPGCC	535	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)