TopFIND 4.0

Q8CGU6: Nicastrin

General Information

Protein names
- Nicastrin
Gene names Ncstn
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID Q8CGU6

2

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MATARGGSGP DPGSRGLLLL SFSVVLAGLC GGNSVERKIY IPLNKTAPCV RLLNATHQIG 
        70         80         90        100        110        120 
CQSSISGDTG VIHVVEKEDD LKWVLTDGPN PPYMVLLEGK LFTRDIMEKL KGETSRIAGL 
       130        140        150        160        170        180 
AVTLAKPNST SSFSPSVQCP NDGFGIYSNS YGPEFAHCKK TLWNELGNGL AYDDFSFPIF 
       190        200        210        220        230        240 
LLEDENETKV IKQCYQDHNL GQNGSAPSFP LCAMQLFSHM HAVISTATCM RRSFIQSTFS 
       250        260        270        280        290        300 
INPEIVCDPL SDYNVWSMLK PINTSGGLEP DVRVVVAATR LDSRSFFWNV APGAESAVAS 
       310        320        330        340        350        360 
FVTQLAAAEA LHKAPDVTTL PRNVMFVFFQ GETFDYIGSS RMVYDMENGK FPVRLENIDS 
       370        380        390        400        410        420 
FVELGQVALR TSLELWMHTD PMSQKNESVK NQVEDLLVTL EQSGADTPQV VLSRLVQSQA 
       430        440        450        460        470        480 
LPPSSLQRFL RARNISGVVL ADHSGSFHNR YYQSIYDTAE NINVTYPESQ SPEEDLNFVT 
       490        500        510        520        530        540 
DTAKALADVA TVLARALYKL AGGTNFNNSI QADPQTVTRL LYGFLVRANN SWFQSILRHD 
       550        560        570        580        590        600 
LRSYLDDGPL QHYIAVSSPT NTTYVVQYAL ANLTGKVTNL TQEQCQDPSK VPNESKDLYE 
       610        620        630        640        650        660 
YSWVQGPWNS NKTERLPRCV RSTVRLARAL SPAFELSQWS STEYSTWAES RWKDIQARIF 
       670        680        690        700    
LIASKELEFI TLIVGFSILV FSLIVTYCIN AKADVLFVAP REPGAVSY

Isoforms

- Isoform 2 of Nicastrin

Sequence View

        10         20         30         40         50         60 
MATARGGSGP DPGSRGLLLL SFSVVLAGLC GGNSVERKIY IPLNKTAPCV RLLNATHQIG 
        70         80         90        100        110        120 
CQSSISGDTG VIHVVEKEDD LKWVLTDGPN PPYMVLLEGK LFTRDIMEKL KGETSRIAGL 
       130        140        150        160        170        180 
AVTLAKPNST SSFSPSVQCP NDGFGIYSNS YGPEFAHCKK TLWNELGNGL AYDDFSFPIF 
       190        200        210        220        230        240 
LLEDENETKV IKQCYQDHNL GQNGSAPSFP LCAMQLFSHM HAVISTATCM RRSFIQSTFS 
       250        260        270        280        290        300 
INPEIVCDPL SDYNVWSMLK PINTSGGLEP DVRVVVAATR LDSRSFFWNV APGAESAVAS 
       310        320        330        340        350        360 
FVTQLAAAEA LHKAPDVTTL PRNVMFVFFQ GETFDYIGSS RMVYDMENGK FPVRLENIDS 
       370        380        390        400        410        420 
FVELGQVALR TSLELWMHTD PMSQKNESVK NQVEDLLVTL EQSGADTPQV VLSRLVQSQA 
       430        440        450        460        470        480 
LPPSSLQRFL RARNISGVVL ADHSGSFHNR YYQSIYDTAE NINVTYPESQ SPEEDLNFVT 
       490        500        510        520        530        540 
DTAKALADVA TVLARALYKL AGGTNFNNSI QADPQTVTRL LYGFLVRANN SWFQSILRHD 
       550        560        570        580        590        600 
LRSYLDDGPL QHYIAVSSPT NTTYVVQYAL ANLTGKVTNL TQEQCQDPSK VPNESKDLYE 
       610        620        630        640        650        660 
YSWVQGPWNS NKTERLPRCV RSTVRLARAL SPAFELSQWS STEYSTWAES RWKDIQARIF 
       670        680        690        700    
LIASKELEFI TLIVGFSILV FSLIVTYCIN AKADVLFVAP REPGAVSY



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8CGU6-1-unknown MATARG... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt193064
    Q8CGU6-35-unknown VERKIY... 35 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8CGU6-35-unknown VERKIY... 35 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt195773

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...QIGCQS 62 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt153010
    ...GAVSY 708 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)