TopFIND 4.0

Q8CHG7: Rap guanine nucleotide exchange factor 2

General Information

Protein names
- Rap guanine nucleotide exchange factor 2
- Cyclic nucleotide ras GEF
- CNrasGEF
- Neural RAP guanine nucleotide exchange protein
- nRap GEP
- PDZ domain-containing guanine nucleotide exchange factor 1
- PDZ-GEF1
- RA-GEF-1
- Ras/Rap1-associating GEF-1
Gene names Rapgef2
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q8CHG7

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MKPLAAPANH GVLGQQEKQS LPADFTKLHL TDSLHPQVTH VSSSHSGCSI TSDSGSSSLS 
        70         80         90        100        110        120 
DIYQATESEA GDMDLSGLPE TAVDSEDDDD EEDIERASDP LMSRDIVRDC LEKDPIDRTD 
       130        140        150        160        170        180 
DDIEQLLEFM HQLPAFANMT MSVRRELCAV MVFAVVERAG TIVLNDGEEL DSWSVILNGS 
       190        200        210        220        230        240 
VEVTYPDGKA EILCMGNSFG VSPTMDKEYM KGVMRTKVDD CQFVCIAQQD YCRILNQVEK 
       250        260        270        280        290        300 
NMQKVEEEGE IVMVKEHREL DRTGTRKGHI VIKGTSERLT MHLVEEHSVV DPTFIEDFLL 
       310        320        330        340        350        360 
TYRTFLSSPM EVGKKLLEWF NDPSLRDKVT RVVLLWVNNH FNDFEGDPAM TRFLEEFENN 
       370        380        390        400        410        420 
LEREKMGGHL RLLNIACAAK AKRRLMTLTK PSREAPLPFI LLGGSEKGFG IFVDSVDSCS 
       430        440        450        460        470        480 
KATEAGLKRG DQILEVNGQN FENIQLSKAM EILRNNTHLS ITVKTNLFVF KELLTRLSEE 
       490        500        510        520        530        540 
KRNGAPHLPK IGDIKKASRY SIPDLAVDVE QVIGLEKVNK KSKANTVGGR NKLKKILDKT 
       550        560        570        580        590        600 
RISILPQKPY NDIGIGQSQD DSIVGLRQTK HIPAALPVSG TLSSSNPDLL QSHHRILDFS 
       610        620        630        640        650        660 
TTPDLPDQVL RVFKADQQSR YIMISKDTTA KEVVIQAIRE FAVTATPEQY SLCEVSVTPE 
       670        680        690        700        710        720 
GVIKQRRLPD QLSKLADRIQ LSGRYYLKNN METETLCSDE DAQELLRESQ ISLLQLSTVE 
       730        740        750        760        770        780 
VATQLSMRNF ELFRNIEPTE YIDDLFKLKS KTSCANLKKF EEVINQETFW VASEILRETN 
       790        800        810        820        830        840 
QLKRMKIIKH FIKIALHCRE CKNFNSMFAI ISGLNLAPVA RLRTTWEKLP NKYEKLFQDL 
       850        860        870        880        890        900 
QDLFDPSRNM AKYRNVLSGQ NLQPPVIPLF PVIKKDLTFL HEGNDSKVDG LVNFEKLRMI 
       910        920        930        940        950        960 
AKEIRHVGRM ASVNMDPALM FRTRKKKWRS LGSLSQGSAN ATVLDVAQTG GHKKRVRRSS 
       970        980        990       1000       1010       1020 
FLNAKKLYED AQMARKVKQY LSNLELEMDE ESLQTLSLQC EPATSTLPKN PGDKKPVKSE 
      1030       1040       1050       1060       1070       1080 
TSPVAPRAGP QQKVQPQQPL AQPQPPHKVS QGLQVPAVSL YPSRKKVPVK DLPPFGINSP 
      1090       1100       1110       1120       1130       1140 
QALKKILSLS EEGSLERHRK QAEDTISNAS SQLSSPPTSP QSSPRKGYAL ALSGTVDNFS 
      1150       1160       1170       1180       1190       1200 
DSGHSEISSR SSIVSNSSFD SVPVSLHDER RQRHSVSIVE SNLGVGRMER RTLMEPDQYS 
      1210       1220       1230       1240       1250       1260 
LGSYAPVSES RGLYAAATVI SSPSTEELSH DQGDRASLDA ADSGRGSWTS CSSGSHDNIQ 
      1270       1280       1290       1300       1310       1320 
TIQHQRSWET LPFGHTHFDY SGDAASIWAS GGHMDQMMFS DHSTKYNRQN QSRESLEQAQ 
      1330       1340       1350       1360       1370       1380 
SRASWASSTG YWGEDSEGDT GTIKRRGGKD VSAEAESSSM VPVTTEEAKP VPMPAHIAVT 
      1390       1400       1410       1420       1430       1440 
PSTTKGLIAR KEGRYREPPP TPPGYVGIPI ADFPEGPCHP ARKPPDYNVA LQRSRMVARP 
      1450       1460       1470       1480       1490    
TEAPAPGQTP PAAAASRPGS KPQWHKPSDA DPRLAPFQPQ GFAGAEEDED EQVSAV

Isoforms



Sequence View



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8CHG7-1-unknown MKPLAA... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...QVSAV 1496 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)