TopFIND 4.0

Q8IWU9: Tryptophan 5-hydroxylase 2

General Information

Protein names
- Tryptophan 5-hydroxylase 2
- 1.14.16.4
- Neuronal tryptophan hydroxylase
- Tryptophan 5-monooxygenase 2
Gene names TPH2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q8IWU9

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MQPAMMMFSS KYWARRGFSL DSAVPEEHQL LGSSTLNKPN SGKNDDKGNK GSSKREAATE 
        70         80         90        100        110        120 
SGKTAVVFSL KNEVGGLVKA LRLFQEKRVN MVHIESRKSR RRSSEVEIFV DCECGKTEFN 
       130        140        150        160        170        180 
ELIQLLKFQT TIVTLNPPEN IWTEEEELED VPWFPRKISE LDKCSHRVLM YGSELDADHP 
       190        200        210        220        230        240 
GFKDNVYRQR RKYFVDVAMG YKYGQPIPRV EYTEEETKTW GVVFRELSKL YPTHACREYL 
       250        260        270        280        290        300 
KNFPLLTKYC GYREDNVPQL EDVSMFLKER SGFTVRPVAG YLSPRDFLAG LAYRVFHCTQ 
       310        320        330        340        350        360 
YIRHGSDPLY TPEPDTCHEL LGHVPLLADP KFAQFSQEIG LASLGASDED VQKLATCYFF 
       370        380        390        400        410        420 
TIEFGLCKQE GQLRAYGAGL LSSIGELKHA LSDKACVKAF DPKTTCLQEC LITTFQEAYF 
       430        440        450        460        470        480 
VSESFEEAKE KMRDFAKSIT RPFSVYFNPY TQSIEILKDT RSIENVVQDL RSDLNTVCDA 
       490    
LNKMNQYLGI 

Isoforms

- Isoform b of Tryptophan 5-hydroxylase 2

Sequence View

        10         20         30         40         50         60 
MQPAMMMFSS KYWARRGFSL DSAVPEEHQL LGSSTLNKPN SGKNDDKGNK GSSKREAATE 
        70         80         90        100        110        120 
SGKTAVVFSL KNEVGGLVKA LRLFQEKRVN MVHIESRKSR RRSSEVEIFV DCECGKTEFN 
       130        140        150        160        170        180 
ELIQLLKFQT TIVTLNPPEN IWTEEEELED VPWFPRKISE LDKCSHRVLM YGSELDADHP 
       190        200        210        220        230        240 
GFKDNVYRQR RKYFVDVAMG YKYGQPIPRV EYTEEETKTW GVVFRELSKL YPTHACREYL 
       250        260        270        280        290        300 
KNFPLLTKYC GYREDNVPQL EDVSMFLKER SGFTVRPVAG YLSPRDFLAG LAYRVFHCTQ 
       310        320        330        340        350        360 
YIRHGSDPLY TPEPDTCHEL LGHVPLLADP KFAQFSQEIG LASLGASDED VQKLATCYFF 
       370        380        390        400        410        420 
TIEFGLCKQE GQLRAYGAGL LSSIGELKHA LSDKACVKAF DPKTTCLQEC LITTFQEAYF 
       430        440        450        460        470        480 
VSESFEEAKE KMRDFAKSIT RPFSVYFNPY TQSIEILKDT RSIENVVQDL RSDLNTVCDA 
       490    
LNKMNQYLGI 



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8IWU9-1-unknown MQPAMM... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8IWU9-1-unknown MQPAMM... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt92845

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...QYLGI 490 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...QYLGI 490 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt88463

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)