TopFIND 4.0

Q8IWW8: Hydroxyacid-oxoacid transhydrogenase, mitochondrial

General Information

Protein names
- Hydroxyacid-oxoacid transhydrogenase, mitochondrial
- HOT
- 1.1.99.24 {ECO:0000269|PubMed:16435184}
- Alcohol dehydrogenase iron-containing protein 1
- ADHFe1
- Fe-containing alcohol dehydrogenase
Gene names ADHFE1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q8IWW8

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAAAARARVA YLLRQLQRAA CQCPTHSHTY SQAPGLSPSG KTTDYAFEMA VSNIRYGAAV 
        70         80         90        100        110        120 
TKEVGMDLKN MGAKNVCLMT DKNLSKLPPV QVAMDSLVKN GIPFTVYDNV RVEPTDSSFM 
       130        140        150        160        170        180 
EAIEFAQKGA FDAYVAVGGG STMDTCKAAN LYASSPHSDF LDYVSAPIGK GKPVSVPLKP 
       190        200        210        220        230        240 
LIAVPTTSGT GSETTGVAIF DYEHLKVKIG ITSRAIKPTL GLIDPLHTLH MPARVVANSG 
       250        260        270        280        290        300 
FDVLCHALES YTTLPYHLRS PCPSNPITRP AYQGSNPISD IWAIHALRIV AKYLKRAVRN 
       310        320        330        340        350        360 
PDDLEARSHM HLASAFAGIG FGNAGVHLCH GMSYPISGLV KMYKAKDYNV DHPLVPHGLS 
       370        380        390        400        410        420 
VVLTSPAVFT FTAQMFPERH LEMAEILGAD TRTARIQDAG LVLADTLRKF LFDLDVDDGL 
       430        440        450        460    
AAVGYSKADI PALVKGTLPQ ERVTKLAPCP QSEEDLAALF EASMKLY

Isoforms

- Isoform 2 of Hydroxyacid-oxoacid transhydrogenase, mitochondrial - Isoform 3 of Hydroxyacid-oxoacid transhydrogenase, mitochondrial - Isoform 4 of Hydroxyacid-oxoacid transhydrogenase, mitochondrial

Sequence View

        10         20         30         40         50         60 
MAAAARARVA YLLRQLQRAA CQCPTHSHTY SQAPGLSPSG KTTDYAFEMA VSNIRYGAAV 
        70         80         90        100        110        120 
TKEVGMDLKN MGAKNVCLMT DKNLSKLPPV QVAMDSLVKN GIPFTVYDNV RVEPTDSSFM 
       130        140        150        160        170        180 
EAIEFAQKGA FDAYVAVGGG STMDTCKAAN LYASSPHSDF LDYVSAPIGK GKPVSVPLKP 
       190        200        210        220        230        240 
LIAVPTTSGT GSETTGVAIF DYEHLKVKIG ITSRAIKPTL GLIDPLHTLH MPARVVANSG 
       250        260        270        280        290        300 
FDVLCHALES YTTLPYHLRS PCPSNPITRP AYQGSNPISD IWAIHALRIV AKYLKRAVRN 
       310        320        330        340        350        360 
PDDLEARSHM HLASAFAGIG FGNAGVHLCH GMSYPISGLV KMYKAKDYNV DHPLVPHGLS 
       370        380        390        400        410        420 
VVLTSPAVFT FTAQMFPERH LEMAEILGAD TRTARIQDAG LVLADTLRKF LFDLDVDDGL 
       430        440        450        460    
AAVGYSKADI PALVKGTLPQ ERVTKLAPCP QSEEDLAALF EASMKLY         10         20         30         40         50         60 
MAAAARARVA YLLRQLQRAA CQCPTHSHTY SQAPGLSPSG KTTDYAFEMA VSNIRYGAAV 
        70         80         90        100        110        120 
TKEVGMDLKN MGAKNVCLMT DKNLSKLPPV QVAMDSLVKN GIPFTVYDNV RVEPTDSSFM 
       130        140        150        160        170        180 
EAIEFAQKGA FDAYVAVGGG STMDTCKAAN LYASSPHSDF LDYVSAPIGK GKPVSVPLKP 
       190        200        210        220        230        240 
LIAVPTTSGT GSETTGVAIF DYEHLKVKIG ITSRAIKPTL GLIDPLHTLH MPARVVANSG 
       250        260        270        280        290        300 
FDVLCHALES YTTLPYHLRS PCPSNPITRP AYQGSNPISD IWAIHALRIV AKYLKRAVRN 
       310        320        330        340        350        360 
PDDLEARSHM HLASAFAGIG FGNAGVHLCH GMSYPISGLV KMYKAKDYNV DHPLVPHGLS 
       370        380        390        400        410        420 
VVLTSPAVFT FTAQMFPERH LEMAEILGAD TRTARIQDAG LVLADTLRKF LFDLDVDDGL 
       430        440        450        460    
AAVGYSKADI PALVKGTLPQ ERVTKLAPCP QSEEDLAALF EASMKLY         10         20         30         40         50         60 
MAAAARARVA YLLRQLQRAA CQCPTHSHTY SQAPGLSPSG KTTDYAFEMA VSNIRYGAAV 
        70         80         90        100        110        120 
TKEVGMDLKN MGAKNVCLMT DKNLSKLPPV QVAMDSLVKN GIPFTVYDNV RVEPTDSSFM 
       130        140        150        160        170        180 
EAIEFAQKGA FDAYVAVGGG STMDTCKAAN LYASSPHSDF LDYVSAPIGK GKPVSVPLKP 
       190        200        210        220        230        240 
LIAVPTTSGT GSETTGVAIF DYEHLKVKIG ITSRAIKPTL GLIDPLHTLH MPARVVANSG 
       250        260        270        280        290        300 
FDVLCHALES YTTLPYHLRS PCPSNPITRP AYQGSNPISD IWAIHALRIV AKYLKRAVRN 
       310        320        330        340        350        360 
PDDLEARSHM HLASAFAGIG FGNAGVHLCH GMSYPISGLV KMYKAKDYNV DHPLVPHGLS 
       370        380        390        400        410        420 
VVLTSPAVFT FTAQMFPERH LEMAEILGAD TRTARIQDAG LVLADTLRKF LFDLDVDDGL 
       430        440        450        460    
AAVGYSKADI PALVKGTLPQ ERVTKLAPCP QSEEDLAALF EASMKLY



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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...SMKLY 467 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...SMKLY 467 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt72844

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)