Q8IX04: Ubiquitin-conjugating enzyme E2 variant 3

General Information

Protein names	- Ubiquitin-conjugating enzyme E2 variant 3 - UEV-3 - EV and lactate/malate dehydrogenase domain-containing protein
Gene names	UEVLD
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8IX04

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Ubiquitin-conjugating enzyme E2 variant 3 - Isoform 3 of Ubiquitin-conjugating enzyme E2 variant 3 - Isoform 4 of Ubiquitin-conjugating enzyme E2 variant 3 - Isoform 5 of Ubiquitin-conjugating enzyme E2 variant 3 - Isoform 6 of Ubiquitin-conjugating enzyme E2 variant 3 - Isoform 7 of Ubiquitin-conjugating enzyme E2 variant 3

Sequence View

        10         20         30         40         50         60
MEFDCEGLRR LLGKYKFRDL TVEELRNVNV FFPHFKYSMD TYVFKDSSQK DLLNFTGTIP
        70         80         90        100        110        120
VMYQGNTYNI PIRFWILDSH PFAPPICFLK PTANMGILVG KHVDAQGRIY LPYLQNWSHP
       130        140        150        160        170        180
KSVIVGLIKE MIAKFQEELP MYSLSSSDEA RQVDLLAYIA KITEGVSDTN SKSWANHENK
       190        200        210        220        230        240
TVNKITVVGG GELGIACTLA ISAKGIADRL VLLDLSEGTK GATMDLEIFN LPNVEISKDL
       250        260        270        280        290        300
SASAHSKVVI FTVNSLGSSQ SYLDVVQSNV DMFRALVPAL GHYSQHSVLL VASQPVEIMT
       310        320        330        340        350        360
YVTWKLSTFP ANRVIGIGCN LDSQRLQYII TNVLKAQTSG KEVWVIGEQG EDKVLTWSGQ
       370        380        390        400        410        420
EEVVSHTSQV QLSNRAMELL RVKGQRSWSV GLSVADMVDS IVNNKKKVHS VSALAKGYYD
       430        440        450        460        470
INSEVFLSLP CILGTNGVSE VIKTTLKEDT VTEKLQSSAS SIHSLQQQLK L         10         20         30         40         50         60
MEFDCEGLRR LLGKYKFRDL TVEELRNVNV FFPHFKYSMD TYVFKDSSQK DLLNFTGTIP
        70         80         90        100        110        120
VMYQGNTYNI PIRFWILDSH PFAPPICFLK PTANMGILVG KHVDAQGRIY LPYLQNWSHP
       130        140        150        160        170        180
KSVIVGLIKE MIAKFQEELP MYSLSSSDEA RQVDLLAYIA KITEGVSDTN SKSWANHENK
       190        200        210        220        230        240
TVNKITVVGG GELGIACTLA ISAKGIADRL VLLDLSEGTK GATMDLEIFN LPNVEISKDL
       250        260        270        280        290        300
SASAHSKVVI FTVNSLGSSQ SYLDVVQSNV DMFRALVPAL GHYSQHSVLL VASQPVEIMT
       310        320        330        340        350        360
YVTWKLSTFP ANRVIGIGCN LDSQRLQYII TNVLKAQTSG KEVWVIGEQG EDKVLTWSGQ
       370        380        390        400        410        420
EEVVSHTSQV QLSNRAMELL RVKGQRSWSV GLSVADMVDS IVNNKKKVHS VSALAKGYYD
       430        440        450        460        470
INSEVFLSLP CILGTNGVSE VIKTTLKEDT VTEKLQSSAS SIHSLQQQLK L         10         20         30         40         50         60
MEFDCEGLRR LLGKYKFRDL TVEELRNVNV FFPHFKYSMD TYVFKDSSQK DLLNFTGTIP
        70         80         90        100        110        120
VMYQGNTYNI PIRFWILDSH PFAPPICFLK PTANMGILVG KHVDAQGRIY LPYLQNWSHP
       130        140        150        160        170        180
KSVIVGLIKE MIAKFQEELP MYSLSSSDEA RQVDLLAYIA KITEGVSDTN SKSWANHENK
       190        200        210        220        230        240
TVNKITVVGG GELGIACTLA ISAKGIADRL VLLDLSEGTK GATMDLEIFN LPNVEISKDL
       250        260        270        280        290        300
SASAHSKVVI FTVNSLGSSQ SYLDVVQSNV DMFRALVPAL GHYSQHSVLL VASQPVEIMT
       310        320        330        340        350        360
YVTWKLSTFP ANRVIGIGCN LDSQRLQYII TNVLKAQTSG KEVWVIGEQG EDKVLTWSGQ
       370        380        390        400        410        420
EEVVSHTSQV QLSNRAMELL RVKGQRSWSV GLSVADMVDS IVNNKKKVHS VSALAKGYYD
       430        440        450        460        470
INSEVFLSLP CILGTNGVSE VIKTTLKEDT VTEKLQSSAS SIHSLQQQLK L         10         20         30         40         50         60
MEFDCEGLRR LLGKYKFRDL TVEELRNVNV FFPHFKYSMD TYVFKDSSQK DLLNFTGTIP
        70         80         90        100        110        120
VMYQGNTYNI PIRFWILDSH PFAPPICFLK PTANMGILVG KHVDAQGRIY LPYLQNWSHP
       130        140        150        160        170        180
KSVIVGLIKE MIAKFQEELP MYSLSSSDEA RQVDLLAYIA KITEGVSDTN SKSWANHENK
       190        200        210        220        230        240
TVNKITVVGG GELGIACTLA ISAKGIADRL VLLDLSEGTK GATMDLEIFN LPNVEISKDL
       250        260        270        280        290        300
SASAHSKVVI FTVNSLGSSQ SYLDVVQSNV DMFRALVPAL GHYSQHSVLL VASQPVEIMT
       310        320        330        340        350        360
YVTWKLSTFP ANRVIGIGCN LDSQRLQYII TNVLKAQTSG KEVWVIGEQG EDKVLTWSGQ
       370        380        390        400        410        420
EEVVSHTSQV QLSNRAMELL RVKGQRSWSV GLSVADMVDS IVNNKKKVHS VSALAKGYYD
       430        440        450        460        470
INSEVFLSLP CILGTNGVSE VIKTTLKEDT VTEKLQSSAS SIHSLQQQLK L         10         20         30         40         50         60
MEFDCEGLRR LLGKYKFRDL TVEELRNVNV FFPHFKYSMD TYVFKDSSQK DLLNFTGTIP
        70         80         90        100        110        120
VMYQGNTYNI PIRFWILDSH PFAPPICFLK PTANMGILVG KHVDAQGRIY LPYLQNWSHP
       130        140        150        160        170        180
KSVIVGLIKE MIAKFQEELP MYSLSSSDEA RQVDLLAYIA KITEGVSDTN SKSWANHENK
       190        200        210        220        230        240
TVNKITVVGG GELGIACTLA ISAKGIADRL VLLDLSEGTK GATMDLEIFN LPNVEISKDL
       250        260        270        280        290        300
SASAHSKVVI FTVNSLGSSQ SYLDVVQSNV DMFRALVPAL GHYSQHSVLL VASQPVEIMT
       310        320        330        340        350        360
YVTWKLSTFP ANRVIGIGCN LDSQRLQYII TNVLKAQTSG KEVWVIGEQG EDKVLTWSGQ
       370        380        390        400        410        420
EEVVSHTSQV QLSNRAMELL RVKGQRSWSV GLSVADMVDS IVNNKKKVHS VSALAKGYYD
       430        440        450        460        470
INSEVFLSLP CILGTNGVSE VIKTTLKEDT VTEKLQSSAS SIHSLQQQLK L         10         20         30         40         50         60
MEFDCEGLRR LLGKYKFRDL TVEELRNVNV FFPHFKYSMD TYVFKDSSQK DLLNFTGTIP
        70         80         90        100        110        120
VMYQGNTYNI PIRFWILDSH PFAPPICFLK PTANMGILVG KHVDAQGRIY LPYLQNWSHP
       130        140        150        160        170        180
KSVIVGLIKE MIAKFQEELP MYSLSSSDEA RQVDLLAYIA KITEGVSDTN SKSWANHENK
       190        200        210        220        230        240
TVNKITVVGG GELGIACTLA ISAKGIADRL VLLDLSEGTK GATMDLEIFN LPNVEISKDL
       250        260        270        280        290        300
SASAHSKVVI FTVNSLGSSQ SYLDVVQSNV DMFRALVPAL GHYSQHSVLL VASQPVEIMT
       310        320        330        340        350        360
YVTWKLSTFP ANRVIGIGCN LDSQRLQYII TNVLKAQTSG KEVWVIGEQG EDKVLTWSGQ
       370        380        390        400        410        420
EEVVSHTSQV QLSNRAMELL RVKGQRSWSV GLSVADMVDS IVNNKKKVHS VSALAKGYYD
       430        440        450        460        470
INSEVFLSLP CILGTNGVSE VIKTTLKEDT VTEKLQSSAS SIHSLQQQLK L

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8IX04-1-acetylation	MEFDCE...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8IX04-1-acetylation	MEFDCE...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8IX04-1-acetylation	MEFDCE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163077
Q8IX04-1-acetylation	MEFDCE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163078
Q8IX04-1-acetylation	MEFDCE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163079
Q8IX04-1-acetylation	MEFDCE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163080
Q8IX04-1-acetylation	MEFDCE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163081
Q8IX04-1-unknown	MEFDCE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8IX04-1-unknown	MEFDCE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93829
Q8IX04-1-unknown	MEFDCE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93830
Q8IX04-1-unknown	MEFDCE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93832
Q8IX04-1-unknown	MEFDCE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93833
Q8IX04-1-unknown	MEFDCE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93834
Q8IX04-39-unknown	MDTYVF...	39		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93831
Q8IX04-39-unknown	MDTYVF...	39		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103581
Q8IX04-39-unknown	MDTYVF...	39		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103582
Q8IX04-39-unknown	MDTYVF...	39		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt103583

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...QQLKL	471	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...QQLKL	471	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt89451

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)