Q8IXI2: Mitochondrial Rho GTPase 1

General Information

Protein names	- Mitochondrial Rho GTPase 1 - MIRO-1 - hMiro-1 - 3.6.5.- - Rac-GTP-binding protein-like protein - Ras homolog gene family member T1
Gene names	RHOT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8IXI2

1 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Mitochondrial Rho GTPase 1 - Isoform 3 of Mitochondrial Rho GTPase 1 - Isoform 4 of Mitochondrial Rho GTPase 1 - Isoform 5 of Mitochondrial Rho GTPase 1 - Isoform 6 of Mitochondrial Rho GTPase 1 - Isoform 7 of Mitochondrial Rho GTPase 1

Sequence View

        10         20         30         40         50         60
MKKDVRILLV GEPRVGKTSL IMSLVSEEFP EEVPPRAEEI TIPADVTPER VPTHIVDYSE
        70         80         90        100        110        120
AEQSDEQLHQ EISQANVICI VYAVNNKHSI DKVTSRWIPL INERTDKDSR LPLILVGNKS
       130        140        150        160        170        180
DLVEYSSMET ILPIMNQYTE IETCVECSAK NLKNISELFY YAQKAVLHPT GPLYCPEEKE
       190        200        210        220        230        240
MKPACIKALT RIFKISDQDN DGTLNDAELN FFQRICFNTP LAPQALEDVK NVVRKHISDG
       250        260        270        280        290        300
VADSGLTLKG FLFLHTLFIQ RGRHETTWTV LRRFGYDDDL DLTPEYLFPL LKIPPDCTTE
       310        320        330        340        350        360
LNHHAYLFLQ STFDKHDLDR DCALSPDELK DLFKVFPYIP WGPDVNNTVC TNERGWITYQ
       370        380        390        400        410        420
GFLSQWTLTT YLDVQRCLEY LGYLGYSILT EQESQASAVT VTRDKKIDLQ KKQTQRNVFR
       430        440        450        460        470        480
CNVIGVKNCG KSGVLQALLG RNLMRQKKIR EDHKSYYAIN TVYVYGQEKY LLLHDISESE
       490        500        510        520        530        540
FLTEAEIICD VVCLVYDVSN PKSFEYCARI FKQHFMDSRI PCLIVAAKSD LHEVKQEYSI
       550        560        570        580        590        600
SPTDFCRKHK MPPPQAFTCN TADAPSKDIF VKLTTMAMYP HVTQADLKSS TFWLRASFGA
       610
TVFAVLGFAM YKALLKQR         10         20         30         40         50         60
MKKDVRILLV GEPRVGKTSL IMSLVSEEFP EEVPPRAEEI TIPADVTPER VPTHIVDYSE
        70         80         90        100        110        120
AEQSDEQLHQ EISQANVICI VYAVNNKHSI DKVTSRWIPL INERTDKDSR LPLILVGNKS
       130        140        150        160        170        180
DLVEYSSMET ILPIMNQYTE IETCVECSAK NLKNISELFY YAQKAVLHPT GPLYCPEEKE
       190        200        210        220        230        240
MKPACIKALT RIFKISDQDN DGTLNDAELN FFQRICFNTP LAPQALEDVK NVVRKHISDG
       250        260        270        280        290        300
VADSGLTLKG FLFLHTLFIQ RGRHETTWTV LRRFGYDDDL DLTPEYLFPL LKIPPDCTTE
       310        320        330        340        350        360
LNHHAYLFLQ STFDKHDLDR DCALSPDELK DLFKVFPYIP WGPDVNNTVC TNERGWITYQ
       370        380        390        400        410        420
GFLSQWTLTT YLDVQRCLEY LGYLGYSILT EQESQASAVT VTRDKKIDLQ KKQTQRNVFR
       430        440        450        460        470        480
CNVIGVKNCG KSGVLQALLG RNLMRQKKIR EDHKSYYAIN TVYVYGQEKY LLLHDISESE
       490        500        510        520        530        540
FLTEAEIICD VVCLVYDVSN PKSFEYCARI FKQHFMDSRI PCLIVAAKSD LHEVKQEYSI
       550        560        570        580        590        600
SPTDFCRKHK MPPPQAFTCN TADAPSKDIF VKLTTMAMYP HVTQADLKSS TFWLRASFGA
       610
TVFAVLGFAM YKALLKQR         10         20         30         40         50         60
MKKDVRILLV GEPRVGKTSL IMSLVSEEFP EEVPPRAEEI TIPADVTPER VPTHIVDYSE
        70         80         90        100        110        120
AEQSDEQLHQ EISQANVICI VYAVNNKHSI DKVTSRWIPL INERTDKDSR LPLILVGNKS
       130        140        150        160        170        180
DLVEYSSMET ILPIMNQYTE IETCVECSAK NLKNISELFY YAQKAVLHPT GPLYCPEEKE
       190        200        210        220        230        240
MKPACIKALT RIFKISDQDN DGTLNDAELN FFQRICFNTP LAPQALEDVK NVVRKHISDG
       250        260        270        280        290        300
VADSGLTLKG FLFLHTLFIQ RGRHETTWTV LRRFGYDDDL DLTPEYLFPL LKIPPDCTTE
       310        320        330        340        350        360
LNHHAYLFLQ STFDKHDLDR DCALSPDELK DLFKVFPYIP WGPDVNNTVC TNERGWITYQ
       370        380        390        400        410        420
GFLSQWTLTT YLDVQRCLEY LGYLGYSILT EQESQASAVT VTRDKKIDLQ KKQTQRNVFR
       430        440        450        460        470        480
CNVIGVKNCG KSGVLQALLG RNLMRQKKIR EDHKSYYAIN TVYVYGQEKY LLLHDISESE
       490        500        510        520        530        540
FLTEAEIICD VVCLVYDVSN PKSFEYCARI FKQHFMDSRI PCLIVAAKSD LHEVKQEYSI
       550        560        570        580        590        600
SPTDFCRKHK MPPPQAFTCN TADAPSKDIF VKLTTMAMYP HVTQADLKSS TFWLRASFGA
       610
TVFAVLGFAM YKALLKQR         10         20         30         40         50         60
MKKDVRILLV GEPRVGKTSL IMSLVSEEFP EEVPPRAEEI TIPADVTPER VPTHIVDYSE
        70         80         90        100        110        120
AEQSDEQLHQ EISQANVICI VYAVNNKHSI DKVTSRWIPL INERTDKDSR LPLILVGNKS
       130        140        150        160        170        180
DLVEYSSMET ILPIMNQYTE IETCVECSAK NLKNISELFY YAQKAVLHPT GPLYCPEEKE
       190        200        210        220        230        240
MKPACIKALT RIFKISDQDN DGTLNDAELN FFQRICFNTP LAPQALEDVK NVVRKHISDG
       250        260        270        280        290        300
VADSGLTLKG FLFLHTLFIQ RGRHETTWTV LRRFGYDDDL DLTPEYLFPL LKIPPDCTTE
       310        320        330        340        350        360
LNHHAYLFLQ STFDKHDLDR DCALSPDELK DLFKVFPYIP WGPDVNNTVC TNERGWITYQ
       370        380        390        400        410        420
GFLSQWTLTT YLDVQRCLEY LGYLGYSILT EQESQASAVT VTRDKKIDLQ KKQTQRNVFR
       430        440        450        460        470        480
CNVIGVKNCG KSGVLQALLG RNLMRQKKIR EDHKSYYAIN TVYVYGQEKY LLLHDISESE
       490        500        510        520        530        540
FLTEAEIICD VVCLVYDVSN PKSFEYCARI FKQHFMDSRI PCLIVAAKSD LHEVKQEYSI
       550        560        570        580        590        600
SPTDFCRKHK MPPPQAFTCN TADAPSKDIF VKLTTMAMYP HVTQADLKSS TFWLRASFGA
       610
TVFAVLGFAM YKALLKQR         10         20         30         40         50         60
MKKDVRILLV GEPRVGKTSL IMSLVSEEFP EEVPPRAEEI TIPADVTPER VPTHIVDYSE
        70         80         90        100        110        120
AEQSDEQLHQ EISQANVICI VYAVNNKHSI DKVTSRWIPL INERTDKDSR LPLILVGNKS
       130        140        150        160        170        180
DLVEYSSMET ILPIMNQYTE IETCVECSAK NLKNISELFY YAQKAVLHPT GPLYCPEEKE
       190        200        210        220        230        240
MKPACIKALT RIFKISDQDN DGTLNDAELN FFQRICFNTP LAPQALEDVK NVVRKHISDG
       250        260        270        280        290        300
VADSGLTLKG FLFLHTLFIQ RGRHETTWTV LRRFGYDDDL DLTPEYLFPL LKIPPDCTTE
       310        320        330        340        350        360
LNHHAYLFLQ STFDKHDLDR DCALSPDELK DLFKVFPYIP WGPDVNNTVC TNERGWITYQ
       370        380        390        400        410        420
GFLSQWTLTT YLDVQRCLEY LGYLGYSILT EQESQASAVT VTRDKKIDLQ KKQTQRNVFR
       430        440        450        460        470        480
CNVIGVKNCG KSGVLQALLG RNLMRQKKIR EDHKSYYAIN TVYVYGQEKY LLLHDISESE
       490        500        510        520        530        540
FLTEAEIICD VVCLVYDVSN PKSFEYCARI FKQHFMDSRI PCLIVAAKSD LHEVKQEYSI
       550        560        570        580        590        600
SPTDFCRKHK MPPPQAFTCN TADAPSKDIF VKLTTMAMYP HVTQADLKSS TFWLRASFGA
       610
TVFAVLGFAM YKALLKQR         10         20         30         40         50         60
MKKDVRILLV GEPRVGKTSL IMSLVSEEFP EEVPPRAEEI TIPADVTPER VPTHIVDYSE
        70         80         90        100        110        120
AEQSDEQLHQ EISQANVICI VYAVNNKHSI DKVTSRWIPL INERTDKDSR LPLILVGNKS
       130        140        150        160        170        180
DLVEYSSMET ILPIMNQYTE IETCVECSAK NLKNISELFY YAQKAVLHPT GPLYCPEEKE
       190        200        210        220        230        240
MKPACIKALT RIFKISDQDN DGTLNDAELN FFQRICFNTP LAPQALEDVK NVVRKHISDG
       250        260        270        280        290        300
VADSGLTLKG FLFLHTLFIQ RGRHETTWTV LRRFGYDDDL DLTPEYLFPL LKIPPDCTTE
       310        320        330        340        350        360
LNHHAYLFLQ STFDKHDLDR DCALSPDELK DLFKVFPYIP WGPDVNNTVC TNERGWITYQ
       370        380        390        400        410        420
GFLSQWTLTT YLDVQRCLEY LGYLGYSILT EQESQASAVT VTRDKKIDLQ KKQTQRNVFR
       430        440        450        460        470        480
CNVIGVKNCG KSGVLQALLG RNLMRQKKIR EDHKSYYAIN TVYVYGQEKY LLLHDISESE
       490        500        510        520        530        540
FLTEAEIICD VVCLVYDVSN PKSFEYCARI FKQHFMDSRI PCLIVAAKSD LHEVKQEYSI
       550        560        570        580        590        600
SPTDFCRKHK MPPPQAFTCN TADAPSKDIF VKLTTMAMYP HVTQADLKSS TFWLRASFGA
       610
TVFAVLGFAM YKALLKQR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

1 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8IXI2-1-unknown	MKKDVR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8IXI2-1-unknown	MKKDVR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81160
Q8IXI2-1-unknown	MKKDVR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81161
Q8IXI2-1-unknown	MKKDVR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81162
Q8IXI2-1-unknown	MKKDVR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81163
Q8IXI2-1-unknown	MKKDVR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81164
Q8IXI2-1-unknown	MKKDVR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt81165
Q8IXI2-1-unknown	MKKDVR...	1		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MAMYPH	580	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76780
...MAMYPH	580	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93076
...MAMYPH	580	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93077
...MAMYPH	580	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93078
...MAMYPH	580	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93079
...LLKQR	618	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LLKQR	618	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76778
...LLKQR	618	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76783
...LLKQR	618	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76779

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)