TopFIND 4.0

Q8IXL6: Extracellular serine/threonine protein kinase FAM20C {ECO:0000305}

General Information

Protein names
- Extracellular serine/threonine protein kinase FAM20C {ECO:0000305}
- 2.7.11.1 {ECO:0000269|PubMed:22582013, ECO:0000269|PubMed:23754375, ECO:0000269|PubMed:25789606}
- Dentin matrix protein 4 {ECO:0000250|UniProtKB:Q5MJS3}
- DMP-4 {ECO:0000250|UniProtKB:Q5MJS3}
- Golgi casein kinase {ECO:0000303|PubMed:22582013}
- Golgi-enriched fraction casein kinase {ECO:0000303|PubMed:22582013}
- GEF-CK {ECO:0000303|PubMed:22582013}
Gene names FAM20C
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q8IXL6

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MKMMLVRRFR VLILMVFLVA CALHIALDLL PRLERRGARP SGEPGCSCAQ PAAEVAAPGW 
        70         80         90        100        110        120 
AQVRGRPGEP PAASSAAGDA GWPNKHTLRI LQDFSSDPSS NLSSHSLEKL PPAAEPAERA 
       130        140        150        160        170        180 
LRGRDPGALR PHDPAHRPLL RDPGPRRSES PPGPGGDASL LARLFEHPLY RVAVPPLTEE 
       190        200        210        220        230        240 
DVLFNVNSDT RLSPKAAENP DWPHAGAEGA EFLSPGEAAV DSYPNWLKFH IGINRYELYS 
       250        260        270        280        290        300 
RHNPAIEALL HDLSSQRITS VAMKSGGTQL KLIMTFQNYG QALFKPMKQT REQETPPDFF 
       310        320        330        340        350        360 
YFSDYERHNA EIAAFHLDRI LDFRRVPPVA GRMVNMTKEI RDVTRDKKLW RTFFISPANN 
       370        380        390        400        410        420 
ICFYGECSYY CSTEHALCGK PDQIEGSLAA FLPDLSLAKR KTWRNPWRRS YHKRKKAEWE 
       430        440        450        460        470        480 
VDPDYCEEVK QTPPYDSSHR ILDVMDMTIF DFLMGNMDRH HYETFEKFGN ETFIIHLDNG 
       490        500        510        520        530        540 
RGFGKYSHDE LSILVPLQQC CRIRKSTYLR LQLLAKEEYK LSLLMAESLR GDQVAPVLYQ 
       550        560        570        580    
PHLEALDRRL RVVLKAVRDC VERNGLHSVV DDDLDTEHRA ASAR

Isoforms

- Isoform 2 of Extracellular serine/threonine protein kinase FAM20C

Sequence View

        10         20         30         40         50         60 
MKMMLVRRFR VLILMVFLVA CALHIALDLL PRLERRGARP SGEPGCSCAQ PAAEVAAPGW 
        70         80         90        100        110        120 
AQVRGRPGEP PAASSAAGDA GWPNKHTLRI LQDFSSDPSS NLSSHSLEKL PPAAEPAERA 
       130        140        150        160        170        180 
LRGRDPGALR PHDPAHRPLL RDPGPRRSES PPGPGGDASL LARLFEHPLY RVAVPPLTEE 
       190        200        210        220        230        240 
DVLFNVNSDT RLSPKAAENP DWPHAGAEGA EFLSPGEAAV DSYPNWLKFH IGINRYELYS 
       250        260        270        280        290        300 
RHNPAIEALL HDLSSQRITS VAMKSGGTQL KLIMTFQNYG QALFKPMKQT REQETPPDFF 
       310        320        330        340        350        360 
YFSDYERHNA EIAAFHLDRI LDFRRVPPVA GRMVNMTKEI RDVTRDKKLW RTFFISPANN 
       370        380        390        400        410        420 
ICFYGECSYY CSTEHALCGK PDQIEGSLAA FLPDLSLAKR KTWRNPWRRS YHKRKKAEWE 
       430        440        450        460        470        480 
VDPDYCEEVK QTPPYDSSHR ILDVMDMTIF DFLMGNMDRH HYETFEKFGN ETFIIHLDNG 
       490        500        510        520        530        540 
RGFGKYSHDE LSILVPLQQC CRIRKSTYLR LQLLAKEEYK LSLLMAESLR GDQVAPVLYQ 
       550        560        570        580    
PHLEALDRRL RVVLKAVRDC VERNGLHSVV DDDLDTEHRA ASAR



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


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Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8IXL6-23-unknown LHIALD... 23 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8IXL6-333-unknown MVNMTK... 333 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt72984

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...AASAR 584 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...AASAR 584 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt68602

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)