Q8IYT2: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

General Information

Protein names	- Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 - 2.1.1.296 {ECO:0000269\|PubMed:21310715} - Cap methyltransferase 2 - Cap2 2'O-ribose methyltransferase 2 - HMTr2 - MTr2 - FtsJ methyltransferase domain-containing protein 1 - Protein adrift homolog
Gene names	CMTR2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8IYT2

1 N-termini

7 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSKCRKTPVQ QLASPASFSP DILADIFELF AKNFSYGKPL NNEWQLPDPS EIFTCDHTEL
        70         80         90        100        110        120
NAFLDLKNSL NEVKNLLSDK KLDEWHEHTA FTNKAGKIIS HVRKSVNAEL CTQAWCKFHE
       130        140        150        160        170        180
ILCSFPLIPQ EAFQNGKLNS LHLCEAPGAF IASLNHYLKS HRFPCHWSWV ANTLNPYHEA
       190        200        210        220        230        240
NDDLMMIMDD RLIANTLHWW YFGPDNTGDI MTLKFLTGLQ NFISSMATVH LVTADGSFDC
       250        260        270        280        290        300
QGNPGEQEAL VSSLHYCEVV TALTTLGNGG SFVLKMFTMF EHCSINLMYL LNCCFDQVHV
       310        320        330        340        350        360
FKPATSKAGN SEVYVVCLHY KGREAIHPLL SKMTLNFGTE MKRKALFPHH VIPDSFLKRH
       370        380        390        400        410        420
EECCVFFHKY QLETISENIR LFECMGKAEQ EKLNNLRDCA IQYFMQKFQL KHLSRNNWLV
       430        440        450        460        470        480
KKSSIGCSTN TKWFGQRNKY FKTYNERKML EALSWKDKVA KGYFNSWAEE HGVYHPGQSS
       490        500        510        520        530        540
ILEGTASNLE CHLWHILEGK KLPKVKCSPF CNGEILKTLN EAIEKSLGGA FNLDSKFRPK
       550        560        570        580        590        600
QQYSCSCHVF SEELIFSELC SLTECLQDEQ VVVPSNQIKC LLVGFSTLRN IKMHIPLEVR
       610        620        630        640        650        660
LLESAELTTF SCSLLHDGDP TYQRLFLDCL LHSLRELHTG DVMILPVLSC FTRFMAGLIF
       670        680        690        700        710        720
VLHSCFRFIT FVCPTSSDPL RTCAVLLCVG YQDLPNPVFR YLQSVNELLS TLLNSDSPQQ
       730        740        750        760        770
VLQFVPMEVL LKGALLDFLW DLNAAIAKRH LHFIIQRERE EIINSLQLQN

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

1 N-termini - 7 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8IYT2-1-unknown	MSKCRK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...HEHTAF	90	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000457679
...HVRKSV	105	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000455080
...IPQEAF	132	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000456476
...LNHYLK	158	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000456036
...NHYLKS	159	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000457399
...LQLQN	770	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LQLQN	770		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LQLQN	770		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)