TopFIND 4.0

Q8IZK6: Mucolipin-2

General Information

Protein names
- Mucolipin-2
- Transient receptor potential channel mucolipin 2
- TRPML2
Gene names MCOLN2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q8IZK6

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MARQPYRFPQ ARIPERGSGV FRLTVRNAMA HRDSEMKEEC LREDLKFYFM SPCEKYRARR 
        70         80         90        100        110        120 
QIPWKLGLQI LKIVMVTTQL VRFGLSNQLV VAFKEDNTVA FKHLFLKGYS GTDEDDYSCS 
       130        140        150        160        170        180 
VYTQEDAYES IFFAINQYHQ LKDITLGTLG YGENEDNRIG LKVCKQHYKK GTMFPSNETL 
       190        200        210        220        230        240 
NIDNDVELDC VQLDLQDLSK KPPDWKNSSF FRLEFYRLLQ VEISFHLKGI DLQTIHSREL 
       250        260        270        280        290        300 
PDCYVFQNTI IFDNKAHSGK IKIYFDSDAK IEECKDLNIF GSTQKNAQYV LVFDAFVIVI 
       310        320        330        340        350        360 
CLASLILCTR SIVLALRLRK RFLNFFLEKY KRPVCDTDQW EFINGWYVLV IISDLMTIIG 
       370        380        390        400        410        420 
SILKMEIKAK NLTNYDLCSI FLGTSTLLVW VGVIRYLGYF QAYNVLILTM QASLPKVLRF 
       430        440        450        460        470        480 
CACAGMIYLG YTFCGWIVLG PYHDKFENLN TVAECLFSLV NGDDMFATFA QIQQKSILVW 
       490        500        510        520        530        540 
LFSRLYLYSF ISLFIYMILS LFIALITDSY DTIKKFQQNG FPETDLQEFL KECSSKEEYQ 
       550        560    
KESSAFLSCI CCRRRKRSDD HLIPIS

Isoforms

- Isoform 2 of Mucolipin-2

Sequence View

        10         20         30         40         50         60 
MARQPYRFPQ ARIPERGSGV FRLTVRNAMA HRDSEMKEEC LREDLKFYFM SPCEKYRARR 
        70         80         90        100        110        120 
QIPWKLGLQI LKIVMVTTQL VRFGLSNQLV VAFKEDNTVA FKHLFLKGYS GTDEDDYSCS 
       130        140        150        160        170        180 
VYTQEDAYES IFFAINQYHQ LKDITLGTLG YGENEDNRIG LKVCKQHYKK GTMFPSNETL 
       190        200        210        220        230        240 
NIDNDVELDC VQLDLQDLSK KPPDWKNSSF FRLEFYRLLQ VEISFHLKGI DLQTIHSREL 
       250        260        270        280        290        300 
PDCYVFQNTI IFDNKAHSGK IKIYFDSDAK IEECKDLNIF GSTQKNAQYV LVFDAFVIVI 
       310        320        330        340        350        360 
CLASLILCTR SIVLALRLRK RFLNFFLEKY KRPVCDTDQW EFINGWYVLV IISDLMTIIG 
       370        380        390        400        410        420 
SILKMEIKAK NLTNYDLCSI FLGTSTLLVW VGVIRYLGYF QAYNVLILTM QASLPKVLRF 
       430        440        450        460        470        480 
CACAGMIYLG YTFCGWIVLG PYHDKFENLN TVAECLFSLV NGDDMFATFA QIQQKSILVW 
       490        500        510        520        530        540 
LFSRLYLYSF ISLFIYMILS LFIALITDSY DTIKKFQQNG FPETDLQEFL KECSSKEEYQ 
       550        560    
KESSAFLSCI CCRRRKRSDD HLIPIS



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8IZK6-1-unknown MARQPY... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8IZK6-29-unknown MAHRDS... 29 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt80624

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LIPIS 566 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...LIPIS 566 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt76242

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)