TopFIND 4.0

Q8IZS8: Voltage-dependent calcium channel subunit alpha-2/delta-3

General Information

Protein names
- Voltage-dependent calcium channel subunit alpha-2/delta-3
- Voltage-gated calcium channel subunit alpha-2/delta-3
- Voltage-dependent calcium channel subunit alpha-2-3
- Voltage-dependent calcium channel subunit delta-3
Gene names CACNA2D3
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q8IZS8

3

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAGPGSPRRA SRGASALLAA ALLYAALGDV VRSEQQIPLS VVKLWASAFG GEIKSIAAKY 
        70         80         90        100        110        120 
SGSQLLQKKY KEYEKDVAIE EIDGLQLVKK LAKNMEEMFH KKSEAVRRLV EAAEEAHLKH 
       130        140        150        160        170        180 
EFDADLQYEY FNAVLINERD KDGNFLELGK EFILAPNDHF NNLPVNISLS DVQVPTNMYN 
       190        200        210        220        230        240 
KDPAIVNGVY WSESLNKVFV DNFDRDPSLI WQYFGSAKGF FRQYPGIKWE PDENGVIAFD 
       250        260        270        280        290        300 
CRNRKWYIQA ATSPKDVVIL VDVSGSMKGL RLTIAKQTVS SILDTLGDDD FFNIIAYNEE 
       310        320        330        340        350        360 
LHYVEPCLNG TLVQADRTNK EHFREHLDKL FAKGIGMLDI ALNEAFNILS DFNHTGQGSI 
       370        380        390        400        410        420 
CSQAIMLITD GAVDTYDTIF AKYNWPDRKV RIFTYLIGRE AAFADNLKWM ACANKGFFTQ 
       430        440        450        460        470        480 
ISTLADVQEN VMEYLHVLSR PKVIDQEHDV VWTEAYIDST LPQAQKLTDD QGPVLMTTVA 
       490        500        510        520        530        540 
MPVFSKQNET RSKGILLGVV GTDVPVKELL KTIPKYKLGI HGYAFAITNN GYILTHPELR 
       550        560        570        580        590        600 
LLYEEGKKRR KPNYSSVDLS EVEWEDRDDV LRNAMVNRKT GKFSMEVKKT VDKGKRVLVM 
       610        620        630        640        650        660 
TNDYYYTDIK GTPFSLGVAL SRGHGKYFFR GNVTIEEGLH DLEHPDVSLA DEWSYCNTDL 
       670        680        690        700        710        720 
HPEHRHLSQL EAIKLYLKGK EPLLQCDKEL IQEVLFDAVV SAPIEAYWTS LALNKSENSD 
       730        740        750        760        770        780 
KGVEVAFLGT RTGLSRINLF VGAEQLTNQD FLKAGDKENI FNADHFPLWY RRAAEQIPGS 
       790        800        810        820        830        840 
FVYSIPFSTG PVNKSNVVTA STSIQLLDER KSPVVAAVGI QMKLEFFQRK FWTASRQCAS 
       850        860        870        880        890        900 
LDGKCSISCD DETVNCYLID NNGFILVSED YTQTGDFFGE IEGAVMNKLL TMGSFKRITL 
       910        920        930        940        950        960 
YDYQAMCRAN KESSDGAHGL LDPYNAFLSA VKWIMTELVL FLVEFNLCSW WHSDMTAKAQ 
       970        980        990       1000       1010       1020 
KLKQTLEPCD TEYPAFVSER TIKETTGNIA CEDCSKSFVI QQIPSSNLFM VVVDSSCLCE 
      1030       1040       1050       1060       1070       1080 
SVAPITMAPI EIRYNESLKC ERLKAQKIRR RPESCHGFHP EENARECGGA PSLQAQTVLL 
      1090    
LLPLLLMLFS R

Isoforms

- Isoform 2 of Voltage-dependent calcium channel subunit alpha-2/delta-3 - Isoform 3 of Voltage-dependent calcium channel subunit alpha-2/delta-3

Sequence View

        10         20         30         40         50         60 
MAGPGSPRRA SRGASALLAA ALLYAALGDV VRSEQQIPLS VVKLWASAFG GEIKSIAAKY 
        70         80         90        100        110        120 
SGSQLLQKKY KEYEKDVAIE EIDGLQLVKK LAKNMEEMFH KKSEAVRRLV EAAEEAHLKH 
       130        140        150        160        170        180 
EFDADLQYEY FNAVLINERD KDGNFLELGK EFILAPNDHF NNLPVNISLS DVQVPTNMYN 
       190        200        210        220        230        240 
KDPAIVNGVY WSESLNKVFV DNFDRDPSLI WQYFGSAKGF FRQYPGIKWE PDENGVIAFD 
       250        260        270        280        290        300 
CRNRKWYIQA ATSPKDVVIL VDVSGSMKGL RLTIAKQTVS SILDTLGDDD FFNIIAYNEE 
       310        320        330        340        350        360 
LHYVEPCLNG TLVQADRTNK EHFREHLDKL FAKGIGMLDI ALNEAFNILS DFNHTGQGSI 
       370        380        390        400        410        420 
CSQAIMLITD GAVDTYDTIF AKYNWPDRKV RIFTYLIGRE AAFADNLKWM ACANKGFFTQ 
       430        440        450        460        470        480 
ISTLADVQEN VMEYLHVLSR PKVIDQEHDV VWTEAYIDST LPQAQKLTDD QGPVLMTTVA 
       490        500        510        520        530        540 
MPVFSKQNET RSKGILLGVV GTDVPVKELL KTIPKYKLGI HGYAFAITNN GYILTHPELR 
       550        560        570        580        590        600 
LLYEEGKKRR KPNYSSVDLS EVEWEDRDDV LRNAMVNRKT GKFSMEVKKT VDKGKRVLVM 
       610        620        630        640        650        660 
TNDYYYTDIK GTPFSLGVAL SRGHGKYFFR GNVTIEEGLH DLEHPDVSLA DEWSYCNTDL 
       670        680        690        700        710        720 
HPEHRHLSQL EAIKLYLKGK EPLLQCDKEL IQEVLFDAVV SAPIEAYWTS LALNKSENSD 
       730        740        750        760        770        780 
KGVEVAFLGT RTGLSRINLF VGAEQLTNQD FLKAGDKENI FNADHFPLWY RRAAEQIPGS 
       790        800        810        820        830        840 
FVYSIPFSTG PVNKSNVVTA STSIQLLDER KSPVVAAVGI QMKLEFFQRK FWTASRQCAS 
       850        860        870        880        890        900 
LDGKCSISCD DETVNCYLID NNGFILVSED YTQTGDFFGE IEGAVMNKLL TMGSFKRITL 
       910        920        930        940        950        960 
YDYQAMCRAN KESSDGAHGL LDPYNAFLSA VKWIMTELVL FLVEFNLCSW WHSDMTAKAQ 
       970        980        990       1000       1010       1020 
KLKQTLEPCD TEYPAFVSER TIKETTGNIA CEDCSKSFVI QQIPSSNLFM VVVDSSCLCE 
      1030       1040       1050       1060       1070       1080 
SVAPITMAPI EIRYNESLKC ERLKAQKIRR RPESCHGFHP EENARECGGA PSLQAQTVLL 
      1090    
LLPLLLMLFS R         10         20         30         40         50         60 
MAGPGSPRRA SRGASALLAA ALLYAALGDV VRSEQQIPLS VVKLWASAFG GEIKSIAAKY 
        70         80         90        100        110        120 
SGSQLLQKKY KEYEKDVAIE EIDGLQLVKK LAKNMEEMFH KKSEAVRRLV EAAEEAHLKH 
       130        140        150        160        170        180 
EFDADLQYEY FNAVLINERD KDGNFLELGK EFILAPNDHF NNLPVNISLS DVQVPTNMYN 
       190        200        210        220        230        240 
KDPAIVNGVY WSESLNKVFV DNFDRDPSLI WQYFGSAKGF FRQYPGIKWE PDENGVIAFD 
       250        260        270        280        290        300 
CRNRKWYIQA ATSPKDVVIL VDVSGSMKGL RLTIAKQTVS SILDTLGDDD FFNIIAYNEE 
       310        320        330        340        350        360 
LHYVEPCLNG TLVQADRTNK EHFREHLDKL FAKGIGMLDI ALNEAFNILS DFNHTGQGSI 
       370        380        390        400        410        420 
CSQAIMLITD GAVDTYDTIF AKYNWPDRKV RIFTYLIGRE AAFADNLKWM ACANKGFFTQ 
       430        440        450        460        470        480 
ISTLADVQEN VMEYLHVLSR PKVIDQEHDV VWTEAYIDST LPQAQKLTDD QGPVLMTTVA 
       490        500        510        520        530        540 
MPVFSKQNET RSKGILLGVV GTDVPVKELL KTIPKYKLGI HGYAFAITNN GYILTHPELR 
       550        560        570        580        590        600 
LLYEEGKKRR KPNYSSVDLS EVEWEDRDDV LRNAMVNRKT GKFSMEVKKT VDKGKRVLVM 
       610        620        630        640        650        660 
TNDYYYTDIK GTPFSLGVAL SRGHGKYFFR GNVTIEEGLH DLEHPDVSLA DEWSYCNTDL 
       670        680        690        700        710        720 
HPEHRHLSQL EAIKLYLKGK EPLLQCDKEL IQEVLFDAVV SAPIEAYWTS LALNKSENSD 
       730        740        750        760        770        780 
KGVEVAFLGT RTGLSRINLF VGAEQLTNQD FLKAGDKENI FNADHFPLWY RRAAEQIPGS 
       790        800        810        820        830        840 
FVYSIPFSTG PVNKSNVVTA STSIQLLDER KSPVVAAVGI QMKLEFFQRK FWTASRQCAS 
       850        860        870        880        890        900 
LDGKCSISCD DETVNCYLID NNGFILVSED YTQTGDFFGE IEGAVMNKLL TMGSFKRITL 
       910        920        930        940        950        960 
YDYQAMCRAN KESSDGAHGL LDPYNAFLSA VKWIMTELVL FLVEFNLCSW WHSDMTAKAQ 
       970        980        990       1000       1010       1020 
KLKQTLEPCD TEYPAFVSER TIKETTGNIA CEDCSKSFVI QQIPSSNLFM VVVDSSCLCE 
      1030       1040       1050       1060       1070       1080 
SVAPITMAPI EIRYNESLKC ERLKAQKIRR RPESCHGFHP EENARECGGA PSLQAQTVLL 
      1090    
LLPLLLMLFS R



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8IZS8-0-unknown RMAGPG... 0 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8IZS8-29-unknown DVVRSE... 29 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8IZS8-95-unknown MEEMFH... 95 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt68944
    Q8IZS8-95-unknown MEEMFH... 95 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt68945

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)