Q8IZW8: Tensin-4

General Information

Protein names	- Tensin-4 - C-terminal tensin-like protein
Gene names	TNS4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8IZW8

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSQVMSSPLL AGGHAVSLAP CDEPRRTLHP APSPSLPPQC SYYTTEGWGA QALMAPVPCM
        70         80         90        100        110        120
GPPGRLQQAP QVEAKATCFL PSPGEKALGT PEDLDSYIDF SLESLNQMIL ELDPTFQLLP
       130        140        150        160        170        180
PGTGGSQAEL AQSTMSMRKK EESEALDIKY IEVTSARSRC HDGPQHCSSP SVTPPFGSLR
       190        200        210        220        230        240
SGGLLLSRDV PRETRSSSES LIFSGNQGRG HQRPLPPSEG LSPRPPNSPS ISIPCMGSKA
       250        260        270        280        290        300
SSPHGLGSPL VASPRLEKRL GGLAPQRGSR ISVLSASPVS DVSYMFGSSQ SLLHSSNSSH
       310        320        330        340        350        360
QSSSRSLESP ANSSSSLHSL GSVSLCTRPS DFQAPRNPTL TMGQPRTPHS PPLAKEHASS
       370        380        390        400        410        420
CPPSITNSMV DIPIVLINGC PEPGSSPPQR TPGHQNSVQP GAASPSNPCP ATRSNSQTLS
       430        440        450        460        470        480
DAPFTTCPEG PARDMQPTMK FVMDTSKYWF KPNITREQAI ELLRKEEPGA FVIRDSSSYR
       490        500        510        520        530        540
GSFGLALKVQ EVPASAQSRP GEDSNDLIRH FLIESSAKGV HLKGADEEPY FGSLSAFVCQ
       550        560        570        580        590        600
HSIMALALPC KLTIPQRELG GADGASDSTD SPASCQKKSA GCHTLYLSSV SVETLTGALA
       610        620        630        640        650        660
VQKAISTTFE RDILPTPTVV HFKVTEQGIT LTDVQRKVFF RRHYPLTTLR FCGMDPEQRK
       670        680        690        700        710
WQKYCKPSWI FGFVAKSQTE PQENVCHLFA EYDMVQPASQ VIGLVTALLQ DAERM

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8IZW8-2-acetylation	SQVMSS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8IZW8-19-unknown	APCDEP...	19		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8IZW8-571-unknown	SPASCQ...	571		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2271

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SDSTDS	570	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2271
...CKPSWI	669	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000463456
...DAERM	715	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	570	STDS.\|.SPAS	inferred from experiment	unknown	MEROPS	Lo SH	Lo SS et al.:Cleavage of cten by caspase-3 d... (C14.003)	15806167,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)