TopFIND 4.0

Q8K2Y9: Cerebral cavernous malformations protein 2 homolog

General Information

Protein names
- Cerebral cavernous malformations protein 2 homolog
- Malcavernin {ECO:0000250|UniProtKB:Q9BSQ5}
- Osmosensing scaffold for MEKK3 {ECO:0000303|PubMed:14634666}
Gene names Ccm2
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q8K2Y9

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MEEEGKKGKK PGIVSPFKRV FLKGEKSRDK KAHEKVTERR PLHTVVLALP ERVEPDRLLS 
        70         80         90        100        110        120 
DYIEKEVKYL GQLTSIPGYL NPSSRTEILH FIDKAKRSHQ LPGHLTQEHD AVLSLSAYNV 
       130        140        150        160        170        180 
KLAWRDGEDI ILRVPIHDIA AVSYVRDDAA HLVVLKTAQD PGISPSQSLC AESSRGLSAG 
       190        200        210        220        230        240 
SLSESAVGPV EACCLVIMAT ESKVAAEELC SLLSQVFQIV YTESTIDFLD RAIFDGASTP 
       250        260        270        280        290        300 
THHLSLHSDD SSTKVDMKDS YDADASTFCF PDSGDVGGLP PLPFCMQTSP HSKTVSESEL 
       310        320        330        340        350        360 
STSATELLQD YMLTLRTKLS SQEIQQFAAL LHEYRNGASI HEFCISLRQL YGDSRKFLLL 
       370        380        390        400        410        420 
GLRPFIPEKD SQHFENFLET IGVKDGRGII TDSFGRHRRA LSTTSTSTIN GNRTTGSPDD 
       430        440        450    
RSAPSEGDEW DRMISDISSD IEALGCSMDQ DSA

Isoforms

- Isoform 2 of Malcavernin - Isoform 2 of Cerebral cavernous malformations protein 2 homolog

Sequence View

        10         20         30         40         50         60 
MEEEGKKGKK PGIVSPFKRV FLKGEKSRDK KAHEKVTERR PLHTVVLALP ERVEPDRLLS 
        70         80         90        100        110        120 
DYIEKEVKYL GQLTSIPGYL NPSSRTEILH FIDKAKRSHQ LPGHLTQEHD AVLSLSAYNV 
       130        140        150        160        170        180 
KLAWRDGEDI ILRVPIHDIA AVSYVRDDAA HLVVLKTAQD PGISPSQSLC AESSRGLSAG 
       190        200        210        220        230        240 
SLSESAVGPV EACCLVIMAT ESKVAAEELC SLLSQVFQIV YTESTIDFLD RAIFDGASTP 
       250        260        270        280        290        300 
THHLSLHSDD SSTKVDMKDS YDADASTFCF PDSGDVGGLP PLPFCMQTSP HSKTVSESEL 
       310        320        330        340        350        360 
STSATELLQD YMLTLRTKLS SQEIQQFAAL LHEYRNGASI HEFCISLRQL YGDSRKFLLL 
       370        380        390        400        410        420 
GLRPFIPEKD SQHFENFLET IGVKDGRGII TDSFGRHRRA LSTTSTSTIN GNRTTGSPDD 
       430        440        450    
RSAPSEGDEW DRMISDISSD IEALGCSMDQ DSA         10         20         30         40         50         60 
MEEEGKKGKK PGIVSPFKRV FLKGEKSRDK KAHEKVTERR PLHTVVLALP ERVEPDRLLS 
        70         80         90        100        110        120 
DYIEKEVKYL GQLTSIPGYL NPSSRTEILH FIDKAKRSHQ LPGHLTQEHD AVLSLSAYNV 
       130        140        150        160        170        180 
KLAWRDGEDI ILRVPIHDIA AVSYVRDDAA HLVVLKTAQD PGISPSQSLC AESSRGLSAG 
       190        200        210        220        230        240 
SLSESAVGPV EACCLVIMAT ESKVAAEELC SLLSQVFQIV YTESTIDFLD RAIFDGASTP 
       250        260        270        280        290        300 
THHLSLHSDD SSTKVDMKDS YDADASTFCF PDSGDVGGLP PLPFCMQTSP HSKTVSESEL 
       310        320        330        340        350        360 
STSATELLQD YMLTLRTKLS SQEIQQFAAL LHEYRNGASI HEFCISLRQL YGDSRKFLLL 
       370        380        390        400        410        420 
GLRPFIPEKD SQHFENFLET IGVKDGRGII TDSFGRHRRA LSTTSTSTIN GNRTTGSPDD 
       430        440        450    
RSAPSEGDEW DRMISDISSD IEALGCSMDQ DSA



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Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8K2Y9-1-unknown MEEEGK... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8K2Y9-11-unknown PGIVSP... 11 inferred from electronic annotation unknown TISdb inferred from TISdb
    Q8K2Y9-11-unknown PGIVSP... 11 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt194909

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...DQDSA 453 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...DQDSA 453 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt65379

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)