TopFIND 4.0

Q8L7L1: Sphingosine kinase 1

General Information

Protein names
- Sphingosine kinase 1
- 2.7.1.91 {ECO:0000269|PubMed:21330371}
Gene names SPHK1
Organism Arabidopsis thaliana
Protease Family
Protease ID
Chromosome location
UniProt ID Q8L7L1

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MDRQPEREND ELPSPAIISD RVLVNGVVTP LTLTAEGELR STESGRRKST LAKEILSFVV 
        70         80         90        100        110        120 
EGNKVRVKTL VEKGGGICCR GSAGDYARND FVFEPLSDES RKLWSDKFHQ HLVSLGRPKK 
       130        140        150        160        170        180 
LLVFVNPFGG KKTARKIFQE EVKPLFEDAN IQLEIQETKY QLHAKEIVRS MDVSKYDGIV 
       190        200        210        220        230        240 
CVSGDGILVE VVNGLLERED WKTAIKLPIG MVPAGSGNGM IKSLLEPVGL PCSATSATIS 
       250        260        270        280        290        300 
IIRGRTRSLD VATISQGTTK FFSVLMLAWG LVADIDIESE KFRWMGSARF DIYGLQRIIC 
       310        320        330        340        350        360 
LRQYHGRILF VPAPGFESYG QRASCSIDKE PSGSDKTLVY QGPDSKLENL DWREMKGPFV 
       370        380        390        400        410        420 
SVWLHNVPWG AENTLAAPDA KFSDGFLDLI VMKDCPKLAL LSLMTKLSDG THVQSPYASY 
       430        440        450        460        470        480 
LKVKAFVLEP GARIDEPDKE GIIDSDGEVL ARGRKSYKCD QKALMSYDKL QISVDQGLAT 
   
LFSPE

Isoforms

- Isoform 2 of Sphingosine kinase 1

Sequence View

        10         20         30         40         50         60 
MDRQPEREND ELPSPAIISD RVLVNGVVTP LTLTAEGELR STESGRRKST LAKEILSFVV 
        70         80         90        100        110        120 
EGNKVRVKTL VEKGGGICCR GSAGDYARND FVFEPLSDES RKLWSDKFHQ HLVSLGRPKK 
       130        140        150        160        170        180 
LLVFVNPFGG KKTARKIFQE EVKPLFEDAN IQLEIQETKY QLHAKEIVRS MDVSKYDGIV 
       190        200        210        220        230        240 
CVSGDGILVE VVNGLLERED WKTAIKLPIG MVPAGSGNGM IKSLLEPVGL PCSATSATIS 
       250        260        270        280        290        300 
IIRGRTRSLD VATISQGTTK FFSVLMLAWG LVADIDIESE KFRWMGSARF DIYGLQRIIC 
       310        320        330        340        350        360 
LRQYHGRILF VPAPGFESYG QRASCSIDKE PSGSDKTLVY QGPDSKLENL DWREMKGPFV 
       370        380        390        400        410        420 
SVWLHNVPWG AENTLAAPDA KFSDGFLDLI VMKDCPKLAL LSLMTKLSDG THVQSPYASY 
       430        440        450        460        470        480 
LKVKAFVLEP GARIDEPDKE GIIDSDGEVL ARGRKSYKCD QKALMSYDKL QISVDQGLAT 
   
LFSPE



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8L7L1-1-unknown MDRQPE... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8L7L1-1-unknown MDRQPE... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt90443

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LFSPE 485 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)