Q8N1G2: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1

General Information

Protein names	- Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 - 2.1.1.57 {ECO:0000269\|PubMed:21310715} - Cap methyltransferase 1 - Cap1 2'O-ribose methyltransferase 1 - MTr1 - hMTr1 - FtsJ methyltransferase domain-containing protein 2 - Interferon-stimulated gene 95 kDa protein - ISG95
Gene names	CMTR1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8N1G2

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKRRTDPECT APIKKQKKRV AELALSLSST SDDEPPSSVS HGAKASTTSL SGSDSETEGK
        70         80         90        100        110        120
QHSSDSFDDA FKADSLVEGT SSRYSMYNSV SQKLMAKMGF REGEGLGKYS QGRKDIVEAS
       130        140        150        160        170        180
SQKGRRGLGL TLRGFDQELN VDWRDEPEPS ACEQVSWFPE CTTEIPDTQE MSDWMVVGKR
       190        200        210        220        230        240
KMIIEDETEF CGEELLHSVL QCKSVFDVLD GEEMRRARTR ANPYEMIRGV FFLNRAAMKM
       250        260        270        280        290        300
ANMDFVFDRM FTNPRDSYGK PLVKDREAEL LYFADVCAGP GGFSEYVLWR KKWHAKGFGM
       310        320        330        340        350        360
TLKGPNDFKL EDFYSASSEL FEPYYGEGGI DGDGDITRPE NISAFRNFVL DNTDRKGVHF
       370        380        390        400        410        420
LMADGGFSVE GQENLQEILS KQLLLCQFLM ALSIVRTGGH FICKTFDLFT PFSVGLVYLL
       430        440        450        460        470        480
YCCFERVCLF KPITSRPANS ERYVVCKGLK VGIDDVRDYL FAVNIKLNQL RNTDSDVNLV
       490        500        510        520        530        540
VPLEVIKGDH EFTDYMIRSN ESHCSLQIKA LAKIHAFVQD TTLSEPRQAE IRKECLRLWG
       550        560        570        580        590        600
IPDQARVAPS SSDPKSKFFE LIQGTEIDIF SYKPTLLTSK TLEKIRPVFD YRCMVSGSEQ
       610        620        630        640        650        660
KFLIGLGKSQ IYTWDGRQSD RWIKLDLKTE LPRDTLLSVE IVHELKGEGK AQRKISAIHI
       670        680        690        700        710        720
LDVLVLNGTD VREQHFNQRI QLAEKFVKAV SKPSRPDMNP IRVKEVYRLE EMEKIFVRLE
       730        740        750        760        770        780
MKIIKGSSGT PKLSYTGRDD RHFVPMGLYI VRTVNEPWTM GFSKSFKKKF FYNKKTKDST
       790        800        810        820        830
FDLPADSIAP FHICYYGRLF WEWGDGIRVH DSQKPQDQDK LSKEDVLSFI QMHRA

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8N1G2-1-unknown	MKRRTD...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8N1G2-26-	SLSSTS...	26		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q8N1G2-26-unknown	SLSSTS...	26		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...FERVCL	428	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000414233
	...QMHRA	835	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)