Q8N2S1: Latent-transforming growth factor beta-binding protein 4

General Information

Protein names	- Latent-transforming growth factor beta-binding protein 4 - LTBP-4
Gene names	LTBP4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8N2S1

3 N-termini

6 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPRPGTSGRR PLLLVLLLPL FAAATSAASP SPSPSQVVEV PGVPSRPASV AVCRCCPGQT
        70         80         90        100        110        120
SRRSRCIRAF CRVRSCQPKK CAGPQRCLNP VPAVPSPSPS VRKRQVSLNW QPLTLQEARA
       130        140        150        160        170        180
LLKRRRPRGP GGRGLLRRRP PQRAPAGKAP VLCPLICHNG GVCVKPDRCL CPPDFAGKFC
       190        200        210        220        230        240
QLHSSGARPP APAVPGLTRS VYTMPLANHR DDEHGVASMV SVHVEHPQEA SVVVHQVERV
       250        260        270        280        290        300
SGPWEEADAE AVARAEAAAR AEAAAPYTVL AQSAPREDGY SDASGFGYCF RELRGGECAS
       310        320        330        340        350        360
PLPGLRTQEV CCRGAGLAWG VHDCQLCSER LGNSERVSAP DGPCPTGFER VNGSCEDVDE
       370        380        390        400        410        420
CATGGRCQHG ECANTRGGYT CVCPDGFLLD SSRSSCISQH VISEAKGPCF RVLRDGGCSL
       430        440        450        460        470        480
PILRNITKQI CCCSRVGKAW GRGCQLCPPF GSEGFREICP AGPGYHYSAS DLRYNTRPLG
       490        500        510        520        530        540
QEPPRVSLSQ PRTLPATSRP SAGFLPTHRL EPRPEPRPDP RPGPELPLPS IPAWTGPEIP
       550        560        570        580        590        600
ESGPSSGMCQ RNPQVCGPGR CISRPSGYTC ACDSGFRLSP QGTRCIDVDE CRRVPPPCAP
       610        620        630        640        650        660
GRCENSPGSF RCVCGPGFRA GPRAAECLDV DECHRVPPPC DLGRCENTPG SFLCVCPAGY
       670        680        690        700        710        720
QAAPHGASCQ DVDECTQSPG LCGRGACKNL PGSFRCVCPA GFRGSACEED VDECAQEPPP
       730        740        750        760        770        780
CGPGRCDNTA GSFHCACPAG FRSRGPGAPC QDVDECARSP PPCTYGRCEN TEGSFQCVCP
       790        800        810        820        830        840
MGFQPNTAGS ECEDVDECEN HLACPGQECV NSPGSFQCRT CPSGHHLHRG RCTDVDECSS
       850        860        870        880        890        900
GAPPCGPHGH CTNTEGSFRC SCAPGYRAPS GRPGPCADVN ECLEGDFCFP HGECLNTDGS
       910        920        930        940        950        960
FACTCAPGYR PGPRGASCLD VDECSEEDLC QSGICTNTDG SFECICPPGH RAGPDLASCL
       970        980        990       1000       1010       1020
DVDECRERGP ALCGSQRCEN SPGSYRCVRD CDPGYHAGPE GTCDDVDECQ EYGPEICGAQ
      1030       1040       1050       1060       1070       1080
RCENTPGSYR CTPACDPGYQ PTPGGGCQDV DECRNRSFCG AHAVCQNLPG SFQCLCDQGY
      1090       1100       1110       1120       1130       1140
EGARDGRHCV DVNECETLQG VCGAALCENV EGSFLCVCPN SPEEFDPMTG RCVPPRTSAG
      1150       1160       1170       1180       1190       1200
TFPGSQPQAP ASPVLPARPP PPPLPRRPST PRQGPVGSGR RECYFDTAAP DACDNILARN
      1210       1220       1230       1240       1250       1260
VTWQECCCTV GEGWGSGCRI QQCPGTETAE YQSLCPHGRG YLAPSGDLSL RRDVDECQLF
      1270       1280       1290       1300       1310       1320
RDQVCKSGVC VNTAPGYSCY CSNGYYYHTQ RLECIDNDEC ADEEPACEGG RCVNTVGSYH
      1330       1340       1350       1360       1370       1380
CTCEPPLVLD GSQRRCVSNE SQSLDDNLGV CWQEVGADLV CSHPRLDRQA TYTECCCLYG
      1390       1400       1410       1420       1430       1440
EAWGMDCALC PAQDSDDFEA LCNVLRPPAY SPPRPGGFGL PYEYGPDLGP PYQGLPYGPE
      1450       1460       1470       1480       1490       1500
LYPPPALPYD PYPPPPGPFA RREAPYGAPR FDMPDFEDDG GPYGESEAPA PPGPGTRWPY
      1510       1520       1530       1540       1550       1560
RSRDTRRSFP EPEEPPEGGS YAGSLAEPYE ELEAEECGIL DGCTNGRCVR VPEGFTCRCF
      1570       1580       1590       1600       1610       1620
DGYRLDMTRM ACVDINECDE AEAASPLCVN ARCLNTDGSF RCICRPGFAP THQPHHCAPA

RPRA

Isoforms

- Isoform 2 of Latent-transforming growth factor beta-binding protein 4 - Isoform 3 of Latent-transforming growth factor beta-binding protein 4 - Isoform 4 of Latent-transforming growth factor beta-binding protein 4

Sequence View

        10         20         30         40         50         60
MPRPGTSGRR PLLLVLLLPL FAAATSAASP SPSPSQVVEV PGVPSRPASV AVCRCCPGQT
        70         80         90        100        110        120
SRRSRCIRAF CRVRSCQPKK CAGPQRCLNP VPAVPSPSPS VRKRQVSLNW QPLTLQEARA
       130        140        150        160        170        180
LLKRRRPRGP GGRGLLRRRP PQRAPAGKAP VLCPLICHNG GVCVKPDRCL CPPDFAGKFC
       190        200        210        220        230        240
QLHSSGARPP APAVPGLTRS VYTMPLANHR DDEHGVASMV SVHVEHPQEA SVVVHQVERV
       250        260        270        280        290        300
SGPWEEADAE AVARAEAAAR AEAAAPYTVL AQSAPREDGY SDASGFGYCF RELRGGECAS
       310        320        330        340        350        360
PLPGLRTQEV CCRGAGLAWG VHDCQLCSER LGNSERVSAP DGPCPTGFER VNGSCEDVDE
       370        380        390        400        410        420
CATGGRCQHG ECANTRGGYT CVCPDGFLLD SSRSSCISQH VISEAKGPCF RVLRDGGCSL
       430        440        450        460        470        480
PILRNITKQI CCCSRVGKAW GRGCQLCPPF GSEGFREICP AGPGYHYSAS DLRYNTRPLG
       490        500        510        520        530        540
QEPPRVSLSQ PRTLPATSRP SAGFLPTHRL EPRPEPRPDP RPGPELPLPS IPAWTGPEIP
       550        560        570        580        590        600
ESGPSSGMCQ RNPQVCGPGR CISRPSGYTC ACDSGFRLSP QGTRCIDVDE CRRVPPPCAP
       610        620        630        640        650        660
GRCENSPGSF RCVCGPGFRA GPRAAECLDV DECHRVPPPC DLGRCENTPG SFLCVCPAGY
       670        680        690        700        710        720
QAAPHGASCQ DVDECTQSPG LCGRGACKNL PGSFRCVCPA GFRGSACEED VDECAQEPPP
       730        740        750        760        770        780
CGPGRCDNTA GSFHCACPAG FRSRGPGAPC QDVDECARSP PPCTYGRCEN TEGSFQCVCP
       790        800        810        820        830        840
MGFQPNTAGS ECEDVDECEN HLACPGQECV NSPGSFQCRT CPSGHHLHRG RCTDVDECSS
       850        860        870        880        890        900
GAPPCGPHGH CTNTEGSFRC SCAPGYRAPS GRPGPCADVN ECLEGDFCFP HGECLNTDGS
       910        920        930        940        950        960
FACTCAPGYR PGPRGASCLD VDECSEEDLC QSGICTNTDG SFECICPPGH RAGPDLASCL
       970        980        990       1000       1010       1020
DVDECRERGP ALCGSQRCEN SPGSYRCVRD CDPGYHAGPE GTCDDVDECQ EYGPEICGAQ
      1030       1040       1050       1060       1070       1080
RCENTPGSYR CTPACDPGYQ PTPGGGCQDV DECRNRSFCG AHAVCQNLPG SFQCLCDQGY
      1090       1100       1110       1120       1130       1140
EGARDGRHCV DVNECETLQG VCGAALCENV EGSFLCVCPN SPEEFDPMTG RCVPPRTSAG
      1150       1160       1170       1180       1190       1200
TFPGSQPQAP ASPVLPARPP PPPLPRRPST PRQGPVGSGR RECYFDTAAP DACDNILARN
      1210       1220       1230       1240       1250       1260
VTWQECCCTV GEGWGSGCRI QQCPGTETAE YQSLCPHGRG YLAPSGDLSL RRDVDECQLF
      1270       1280       1290       1300       1310       1320
RDQVCKSGVC VNTAPGYSCY CSNGYYYHTQ RLECIDNDEC ADEEPACEGG RCVNTVGSYH
      1330       1340       1350       1360       1370       1380
CTCEPPLVLD GSQRRCVSNE SQSLDDNLGV CWQEVGADLV CSHPRLDRQA TYTECCCLYG
      1390       1400       1410       1420       1430       1440
EAWGMDCALC PAQDSDDFEA LCNVLRPPAY SPPRPGGFGL PYEYGPDLGP PYQGLPYGPE
      1450       1460       1470       1480       1490       1500
LYPPPALPYD PYPPPPGPFA RREAPYGAPR FDMPDFEDDG GPYGESEAPA PPGPGTRWPY
      1510       1520       1530       1540       1550       1560
RSRDTRRSFP EPEEPPEGGS YAGSLAEPYE ELEAEECGIL DGCTNGRCVR VPEGFTCRCF
      1570       1580       1590       1600       1610       1620
DGYRLDMTRM ACVDINECDE AEAASPLCVN ARCLNTDGSF RCICRPGFAP THQPHHCAPA

RPRA         10         20         30         40         50         60
MPRPGTSGRR PLLLVLLLPL FAAATSAASP SPSPSQVVEV PGVPSRPASV AVCRCCPGQT
        70         80         90        100        110        120
SRRSRCIRAF CRVRSCQPKK CAGPQRCLNP VPAVPSPSPS VRKRQVSLNW QPLTLQEARA
       130        140        150        160        170        180
LLKRRRPRGP GGRGLLRRRP PQRAPAGKAP VLCPLICHNG GVCVKPDRCL CPPDFAGKFC
       190        200        210        220        230        240
QLHSSGARPP APAVPGLTRS VYTMPLANHR DDEHGVASMV SVHVEHPQEA SVVVHQVERV
       250        260        270        280        290        300
SGPWEEADAE AVARAEAAAR AEAAAPYTVL AQSAPREDGY SDASGFGYCF RELRGGECAS
       310        320        330        340        350        360
PLPGLRTQEV CCRGAGLAWG VHDCQLCSER LGNSERVSAP DGPCPTGFER VNGSCEDVDE
       370        380        390        400        410        420
CATGGRCQHG ECANTRGGYT CVCPDGFLLD SSRSSCISQH VISEAKGPCF RVLRDGGCSL
       430        440        450        460        470        480
PILRNITKQI CCCSRVGKAW GRGCQLCPPF GSEGFREICP AGPGYHYSAS DLRYNTRPLG
       490        500        510        520        530        540
QEPPRVSLSQ PRTLPATSRP SAGFLPTHRL EPRPEPRPDP RPGPELPLPS IPAWTGPEIP
       550        560        570        580        590        600
ESGPSSGMCQ RNPQVCGPGR CISRPSGYTC ACDSGFRLSP QGTRCIDVDE CRRVPPPCAP
       610        620        630        640        650        660
GRCENSPGSF RCVCGPGFRA GPRAAECLDV DECHRVPPPC DLGRCENTPG SFLCVCPAGY
       670        680        690        700        710        720
QAAPHGASCQ DVDECTQSPG LCGRGACKNL PGSFRCVCPA GFRGSACEED VDECAQEPPP
       730        740        750        760        770        780
CGPGRCDNTA GSFHCACPAG FRSRGPGAPC QDVDECARSP PPCTYGRCEN TEGSFQCVCP
       790        800        810        820        830        840
MGFQPNTAGS ECEDVDECEN HLACPGQECV NSPGSFQCRT CPSGHHLHRG RCTDVDECSS
       850        860        870        880        890        900
GAPPCGPHGH CTNTEGSFRC SCAPGYRAPS GRPGPCADVN ECLEGDFCFP HGECLNTDGS
       910        920        930        940        950        960
FACTCAPGYR PGPRGASCLD VDECSEEDLC QSGICTNTDG SFECICPPGH RAGPDLASCL
       970        980        990       1000       1010       1020
DVDECRERGP ALCGSQRCEN SPGSYRCVRD CDPGYHAGPE GTCDDVDECQ EYGPEICGAQ
      1030       1040       1050       1060       1070       1080
RCENTPGSYR CTPACDPGYQ PTPGGGCQDV DECRNRSFCG AHAVCQNLPG SFQCLCDQGY
      1090       1100       1110       1120       1130       1140
EGARDGRHCV DVNECETLQG VCGAALCENV EGSFLCVCPN SPEEFDPMTG RCVPPRTSAG
      1150       1160       1170       1180       1190       1200
TFPGSQPQAP ASPVLPARPP PPPLPRRPST PRQGPVGSGR RECYFDTAAP DACDNILARN
      1210       1220       1230       1240       1250       1260
VTWQECCCTV GEGWGSGCRI QQCPGTETAE YQSLCPHGRG YLAPSGDLSL RRDVDECQLF
      1270       1280       1290       1300       1310       1320
RDQVCKSGVC VNTAPGYSCY CSNGYYYHTQ RLECIDNDEC ADEEPACEGG RCVNTVGSYH
      1330       1340       1350       1360       1370       1380
CTCEPPLVLD GSQRRCVSNE SQSLDDNLGV CWQEVGADLV CSHPRLDRQA TYTECCCLYG
      1390       1400       1410       1420       1430       1440
EAWGMDCALC PAQDSDDFEA LCNVLRPPAY SPPRPGGFGL PYEYGPDLGP PYQGLPYGPE
      1450       1460       1470       1480       1490       1500
LYPPPALPYD PYPPPPGPFA RREAPYGAPR FDMPDFEDDG GPYGESEAPA PPGPGTRWPY
      1510       1520       1530       1540       1550       1560
RSRDTRRSFP EPEEPPEGGS YAGSLAEPYE ELEAEECGIL DGCTNGRCVR VPEGFTCRCF
      1570       1580       1590       1600       1610       1620
DGYRLDMTRM ACVDINECDE AEAASPLCVN ARCLNTDGSF RCICRPGFAP THQPHHCAPA

RPRA         10         20         30         40         50         60
MPRPGTSGRR PLLLVLLLPL FAAATSAASP SPSPSQVVEV PGVPSRPASV AVCRCCPGQT
        70         80         90        100        110        120
SRRSRCIRAF CRVRSCQPKK CAGPQRCLNP VPAVPSPSPS VRKRQVSLNW QPLTLQEARA
       130        140        150        160        170        180
LLKRRRPRGP GGRGLLRRRP PQRAPAGKAP VLCPLICHNG GVCVKPDRCL CPPDFAGKFC
       190        200        210        220        230        240
QLHSSGARPP APAVPGLTRS VYTMPLANHR DDEHGVASMV SVHVEHPQEA SVVVHQVERV
       250        260        270        280        290        300
SGPWEEADAE AVARAEAAAR AEAAAPYTVL AQSAPREDGY SDASGFGYCF RELRGGECAS
       310        320        330        340        350        360
PLPGLRTQEV CCRGAGLAWG VHDCQLCSER LGNSERVSAP DGPCPTGFER VNGSCEDVDE
       370        380        390        400        410        420
CATGGRCQHG ECANTRGGYT CVCPDGFLLD SSRSSCISQH VISEAKGPCF RVLRDGGCSL
       430        440        450        460        470        480
PILRNITKQI CCCSRVGKAW GRGCQLCPPF GSEGFREICP AGPGYHYSAS DLRYNTRPLG
       490        500        510        520        530        540
QEPPRVSLSQ PRTLPATSRP SAGFLPTHRL EPRPEPRPDP RPGPELPLPS IPAWTGPEIP
       550        560        570        580        590        600
ESGPSSGMCQ RNPQVCGPGR CISRPSGYTC ACDSGFRLSP QGTRCIDVDE CRRVPPPCAP
       610        620        630        640        650        660
GRCENSPGSF RCVCGPGFRA GPRAAECLDV DECHRVPPPC DLGRCENTPG SFLCVCPAGY
       670        680        690        700        710        720
QAAPHGASCQ DVDECTQSPG LCGRGACKNL PGSFRCVCPA GFRGSACEED VDECAQEPPP
       730        740        750        760        770        780
CGPGRCDNTA GSFHCACPAG FRSRGPGAPC QDVDECARSP PPCTYGRCEN TEGSFQCVCP
       790        800        810        820        830        840
MGFQPNTAGS ECEDVDECEN HLACPGQECV NSPGSFQCRT CPSGHHLHRG RCTDVDECSS
       850        860        870        880        890        900
GAPPCGPHGH CTNTEGSFRC SCAPGYRAPS GRPGPCADVN ECLEGDFCFP HGECLNTDGS
       910        920        930        940        950        960
FACTCAPGYR PGPRGASCLD VDECSEEDLC QSGICTNTDG SFECICPPGH RAGPDLASCL
       970        980        990       1000       1010       1020
DVDECRERGP ALCGSQRCEN SPGSYRCVRD CDPGYHAGPE GTCDDVDECQ EYGPEICGAQ
      1030       1040       1050       1060       1070       1080
RCENTPGSYR CTPACDPGYQ PTPGGGCQDV DECRNRSFCG AHAVCQNLPG SFQCLCDQGY
      1090       1100       1110       1120       1130       1140
EGARDGRHCV DVNECETLQG VCGAALCENV EGSFLCVCPN SPEEFDPMTG RCVPPRTSAG
      1150       1160       1170       1180       1190       1200
TFPGSQPQAP ASPVLPARPP PPPLPRRPST PRQGPVGSGR RECYFDTAAP DACDNILARN
      1210       1220       1230       1240       1250       1260
VTWQECCCTV GEGWGSGCRI QQCPGTETAE YQSLCPHGRG YLAPSGDLSL RRDVDECQLF
      1270       1280       1290       1300       1310       1320
RDQVCKSGVC VNTAPGYSCY CSNGYYYHTQ RLECIDNDEC ADEEPACEGG RCVNTVGSYH
      1330       1340       1350       1360       1370       1380
CTCEPPLVLD GSQRRCVSNE SQSLDDNLGV CWQEVGADLV CSHPRLDRQA TYTECCCLYG
      1390       1400       1410       1420       1430       1440
EAWGMDCALC PAQDSDDFEA LCNVLRPPAY SPPRPGGFGL PYEYGPDLGP PYQGLPYGPE
      1450       1460       1470       1480       1490       1500
LYPPPALPYD PYPPPPGPFA RREAPYGAPR FDMPDFEDDG GPYGESEAPA PPGPGTRWPY
      1510       1520       1530       1540       1550       1560
RSRDTRRSFP EPEEPPEGGS YAGSLAEPYE ELEAEECGIL DGCTNGRCVR VPEGFTCRCF
      1570       1580       1590       1600       1610       1620
DGYRLDMTRM ACVDINECDE AEAASPLCVN ARCLNTDGSF RCICRPGFAP THQPHHCAPA

RPRA

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q8N2S1-28-unknown	ASPSPS...	28	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8N2S1-548-unknown	MCQRNP...	548	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000441054
Q8N2S1-548-unknown	MCQRNP...	548	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131541
Q8N2S1-548-unknown	MCQRNP...	548	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131542
Q8N2S1-893-unknown	ECLNTD...	893	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000469785
Q8N2S1-893-unknown	ECLNTD...	893	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131538
Q8N2S1-893-unknown	ECLNTD...	893	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131539

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TGRCVP	1133	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000243562
...TGRCVP	1133	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112006
...TGRCVP	1133	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112004
...TGRCVP	1133	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112005
...PARPPP	1160	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000472995
...PARPPP	1160	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt111998
...PARPPP	1160	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt111996
...PARPPP	1160	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt111997
...CPAQDS	1394	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000469785
...CPAQDS	1394	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt111994
...CPAQDS	1394	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt111992
...CPAQDS	1394	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt111993
...GSLAEP	1527	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000470824
...GSLAEP	1527	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt111990
...GSLAEP	1527	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt111988
...GSLAEP	1527	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt111989
...PYEELE	1532	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000441054
...PYEELE	1532	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112002
...PYEELE	1532	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112000
...PYEELE	1532	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt112001
...ARPRA	1624	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ARPRA	1624	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75669
...ARPRA	1624	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75667
...ARPRA	1624	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75668

TopFIND

Q8N2S1: Latent-transforming growth factor beta-binding protein 4

General Information

3

N-termini

6

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 6 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates