Q8N5S9: Calcium/calmodulin-dependent protein kinase kinase 1

General Information

Protein names	- Calcium/calmodulin-dependent protein kinase kinase 1 - CaM-KK 1 - CaM-kinase kinase 1 - CaMKK 1 - 2.7.11.17 - CaM-kinase IV kinase - Calcium/calmodulin-dependent protein kinase kinase alpha - CaM-KK alpha - CaM-kinase kinase alpha - CaMKK alpha
Gene names	CAMKK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8N5S9

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEGGPAVCCQ DPRAELVERV AAIDVTHLEE ADGGPEPTRN GVDPPPRARA ASVIPGSTSR
        70         80         90        100        110        120
LLPARPSLSA RKLSLQERPA GSYLEAQAGP YATGPASHIS PRAWRRPTIE SHHVAISDAE
       130        140        150        160        170        180
DCVQLNQYKL QSEIGKGAYG VVRLAYNESE DRHYAMKVLS KKKLLKQYGF PRRPPPRGSQ
       190        200        210        220        230        240
AAQGGPAKQL LPLERVYQEI AILKKLDHVN VVKLIEVLDD PAEDNLYLVF DLLRKGPVME
       250        260        270        280        290        300
VPCDKPFSEE QARLYLRDVI LGLEYLHCQK IVHRDIKPSN LLLGDDGHVK IADFGVSNQF
       310        320        330        340        350        360
EGNDAQLSST AGTPAFMAPE AISDSGQSFS GKALDVWATG VTLYCFVYGK CPFIDDFILA
       370        380        390        400        410        420
LHRKIKNEPV VFPEEPEISE ELKDLILKML DKNPETRIGV PDIKLHPWVT KNGEEPLPSE
       430        440        450        460        470        480
EEHCSVVEVT EEEVKNSVRL IPSWTTVILV KSMLRKRSFG NPFEPQARRE ERSMSAPGNL
       490        500
LVKEGFGEGG KSPELPGVQE DEAAS

Isoforms

- Isoform 2 of Calcium/calmodulin-dependent protein kinase kinase 1

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8N5S9-1-acetylation	MEGGPA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8N5S9-1-acetylation	MEGGPA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8N5S9-1-acetylation	MEGGPA...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162467
Q8N5S9-1-unknown	MEGGPA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8N5S9-1-unknown	MEGGPA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79033
Q8N5S9-33-unknown	GGPEPT...	33			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8N5S9-33-unknown	GGPEPT...	33		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt161742

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...GNLLVK	482	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt74651
	...DEAAS	505	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)