TopFIND 4.0

Q8N726: Tumor suppressor ARF {ECO:0000305}

General Information

Protein names
- Tumor suppressor ARF {ECO:0000305}
- Alternative reading frame {ECO:0000303|PubMed:9724636}
- ARF {ECO:0000303|PubMed:9724636}
- Cyclin-dependent kinase inhibitor 2A {ECO:0000312|HGNC:HGNC:1787}
- p14ARF {ECO:0000303|PubMed:9724636}
Gene names CDKN2A
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q8N726

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MVRRFLVTLR IRRACGPPRV RVFVVHIPRL TGEWAAPGAP AAVALVLMLL RSQRLGQQPL 
        70         80         90        100        110        120 
PRRPGHDDGQ RPSGGAAAAP RRGAQLRRPR HSHPTRARRC PGGLPGHAGG AAPGRGAAGR 
       130    
ARCLGPSARG PG

Isoforms

- Isoform 6 of Cyclin-dependent kinase inhibitor 2A, isoform 4 - Isoform smARF of Tumor suppressor ARF

Sequence View

        10         20         30         40         50         60 
MVRRFLVTLR IRRACGPPRV RVFVVHIPRL TGEWAAPGAP AAVALVLMLL RSQRLGQQPL 
        70         80         90        100        110        120 
PRRPGHDDGQ RPSGGAAAAP RRGAQLRRPR HSHPTRARRC PGGLPGHAGG AAPGRGAAGR 
       130    
ARCLGPSARG PG         10         20         30         40         50         60 
MVRRFLVTLR IRRACGPPRV RVFVVHIPRL TGEWAAPGAP AAVALVLMLL RSQRLGQQPL 
        70         80         90        100        110        120 
PRRPGHDDGQ RPSGGAAAAP RRGAQLRRPR HSHPTRARRC PGGLPGHAGG AAPGRGAAGR 
       130    
ARCLGPSARG PG



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Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8N726-1-unknown MVRRFL... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8N726-48-unknown MLLRSQ... 48 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt69928
    Q8N726-66-unknown HDDGQR... 66 inferred from electronic annotation unknown TISdb inferred from TISdb
    Q8N726-66-unknown HDDGQR... 66 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt196424

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...ARGPG 132 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...ARGPG 132 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt65546

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)