TopFIND 4.0

Q8N884: Cyclic GMP-AMP synthase {ECO:0000303|PubMed:23258413}

General Information

Protein names
- Cyclic GMP-AMP synthase {ECO:0000303|PubMed:23258413}
- cGAMP synthase {ECO:0000303|PubMed:23258413}
- cGAS {ECO:0000303|PubMed:23258413}
- h-cGAS {ECO:0000303|PubMed:23258413}
- 2.7.7.86 {ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:28934246, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30799039}
- 2'3'-cGAMP synthase {ECO:0000303|PubMed:23258413}
- Mab-21 domain-containing protein 1
Gene names MB21D1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q8N884

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MQPWHGKAMQ RASEAGATAP KASARNARGA PMDPTESPAA PEAALPKAGK FGPARKSGSR 
        70         80         90        100        110        120 
QKKSAPDTQE RPPVRATGAR AKKAPQRAQD TQPSDATSAP GAEGLEPPAA REPALSRAGS 
       130        140        150        160        170        180 
CRQRGARCST KPRPPPGPWD VPSPGLPVSA PILVRRDAAP GASKLRAVLE KLKLSRDDIS 
       190        200        210        220        230        240 
TAAGMVKGVV DHLLLRLKCD SAFRGVGLLN TGSYYEHVKI SAPNEFDVMF KLEVPRIQLE 
       250        260        270        280        290        300 
EYSNTRAYYF VKFKRNPKEN PLSQFLEGEI LSASKMLSKF RKIIKEEIND IKDTDVIMKR 
       310        320        330        340        350        360 
KRGGSPAVTL LISEKISVDI TLALESKSSW PASTQEGLRI QNWLSAKVRK QLRLKPFYLV 
       370        380        390        400        410        420 
PKHAKEGNGF QEETWRLSFS HIEKEILNNH GKSKTCCENK EEKCCRKDCL KLMKYLLEQL 
       430        440        450        460        470        480 
KERFKDKKHL DKFSSYHVKT AFFHVCTQNP QDSQWDRKDL GLCFDNCVTY FLQCLRTEKL 
       490        500        510        520    
ENYFIPEFNL FSSNLIDKRS KEFLTKQIEY ERNNEFPVFD EF

Isoforms

- Isoform 2 of Cyclic GMP-AMP synthase

Sequence View

        10         20         30         40         50         60 
MQPWHGKAMQ RASEAGATAP KASARNARGA PMDPTESPAA PEAALPKAGK FGPARKSGSR 
        70         80         90        100        110        120 
QKKSAPDTQE RPPVRATGAR AKKAPQRAQD TQPSDATSAP GAEGLEPPAA REPALSRAGS 
       130        140        150        160        170        180 
CRQRGARCST KPRPPPGPWD VPSPGLPVSA PILVRRDAAP GASKLRAVLE KLKLSRDDIS 
       190        200        210        220        230        240 
TAAGMVKGVV DHLLLRLKCD SAFRGVGLLN TGSYYEHVKI SAPNEFDVMF KLEVPRIQLE 
       250        260        270        280        290        300 
EYSNTRAYYF VKFKRNPKEN PLSQFLEGEI LSASKMLSKF RKIIKEEIND IKDTDVIMKR 
       310        320        330        340        350        360 
KRGGSPAVTL LISEKISVDI TLALESKSSW PASTQEGLRI QNWLSAKVRK QLRLKPFYLV 
       370        380        390        400        410        420 
PKHAKEGNGF QEETWRLSFS HIEKEILNNH GKSKTCCENK EEKCCRKDCL KLMKYLLEQL 
       430        440        450        460        470        480 
KERFKDKKHL DKFSSYHVKT AFFHVCTQNP QDSQWDRKDL GLCFDNCVTY FLQCLRTEKL 
       490        500        510        520    
ENYFIPEFNL FSSNLIDKRS KEFLTKQIEY ERNNEFPVFD EF



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8N884-1-unknown MQPWHG... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt70454
    Q8N884-1-Acetylation MQPWHG... 1 acetylation- inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8N884-1-Acetylation MQPWHG... 1 acetylation- inferred from isoform by sequence similarity unknown TopFIND inferred from TNt107734

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...VFDEF 522 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)