TopFIND 4.0

Q8NB16: Mixed lineage kinase domain-like protein

General Information

Protein names
- Mixed lineage kinase domain-like protein
- hMLKL
Gene names MLKL
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q8NB16

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MENLKHIITL GQVIHKRCEE MKYCKKQCRR LGHRVLGLIK PLEMLQDQGK RSVPSEKLTT 
        70         80         90        100        110        120 
AMNRFKAALE EANGEIEKFS NRSNICRFLT ASQDKILFKD VNRKLSDVWK ELSLLLQVEQ 
       130        140        150        160        170        180 
RMPVSPISQG ASWAQEDQQD ADEDRRAFQM LRRDNEKIEA SLRRLEINMK EIKETLRQYL 
       190        200        210        220        230        240 
PPKCMQEIPQ EQIKEIKKEQ LSGSPWILLR ENEVSTLYKG EYHRAPVAIK VFKKLQAGSI 
       250        260        270        280        290        300 
AIVRQTFNKE IKTMKKFESP NILRIFGICI DETVTPPQFS IVMEYCELGT LRELLDREKD 
       310        320        330        340        350        360 
LTLGKRMVLV LGAARGLYRL HHSEAPELHG KIRSSNFLVT QGYQVKLAGF ELRKTQTSMS 
       370        380        390        400        410        420 
LGTTREKTDR VKSTAYLSPQ ELEDVFYQYD VKSEIYSFGI VLWEIATGDI PFQGCNSEKI 
       430        440        450        460        470    
RKLVAVKRQQ EPLGEDCPSE LREIIDECRA HDPSVRPSVD EILKKLSTFS K

Isoforms

- Isoform 2 of Mixed lineage kinase domain-like protein

Sequence View

        10         20         30         40         50         60 
MENLKHIITL GQVIHKRCEE MKYCKKQCRR LGHRVLGLIK PLEMLQDQGK RSVPSEKLTT 
        70         80         90        100        110        120 
AMNRFKAALE EANGEIEKFS NRSNICRFLT ASQDKILFKD VNRKLSDVWK ELSLLLQVEQ 
       130        140        150        160        170        180 
RMPVSPISQG ASWAQEDQQD ADEDRRAFQM LRRDNEKIEA SLRRLEINMK EIKETLRQYL 
       190        200        210        220        230        240 
PPKCMQEIPQ EQIKEIKKEQ LSGSPWILLR ENEVSTLYKG EYHRAPVAIK VFKKLQAGSI 
       250        260        270        280        290        300 
AIVRQTFNKE IKTMKKFESP NILRIFGICI DETVTPPQFS IVMEYCELGT LRELLDREKD 
       310        320        330        340        350        360 
LTLGKRMVLV LGAARGLYRL HHSEAPELHG KIRSSNFLVT QGYQVKLAGF ELRKTQTSMS 
       370        380        390        400        410        420 
LGTTREKTDR VKSTAYLSPQ ELEDVFYQYD VKSEIYSFGI VLWEIATGDI PFQGCNSEKI 
       430        440        450        460        470    
RKLVAVKRQQ EPLGEDCPSE LREIIDECRA HDPSVRPSVD EILKKLSTFS K



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8NB16-1-unknown MENLKH... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8NB16-1-unknown MENLKH... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt81254

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...STFSK 471 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...STFSK 471 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt76872

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)