TopFIND 4.0

Q8NC67: Neuropilin and tolloid-like protein 2

General Information

Protein names
- Neuropilin and tolloid-like protein 2
- Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2
Gene names NETO2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q8NC67

2

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MALERLCSVL KVLLITVLVV EGIAVAQKTQ DGQNIGIKHI PATQCGIWVR TSNGGHFASP 
        70         80         90        100        110        120 
NYPDSYPPNK ECIYILEAAP RQRIELTFDE HYYIEPSFEC RFDHLEVRDG PFGFSPLIDR 
       130        140        150        160        170        180 
YCGVKSPPLI RSTGRFMWIK FSSDEELEGL GFRAKYSFIP DPDFTYLGGI LNPIPDCQFE 
       190        200        210        220        230        240 
LSGADGIVRS SQVEQEEKTK PGQAVDCIWT IKATPKAKIY LRFLDYQMEH SNECKRNFVA 
       250        260        270        280        290        300 
VYDGSSSIEN LKAKFCSTVA NDVMLKTGIG VIRMWADEGS RLSRFRMLFT SFVEPPCTSS 
       310        320        330        340        350        360 
TFFCHSNMCI NNSLVCNGVQ NCAYPWDENH CKEKKKAGVF EQITKTHGTI IGITSGIVLV 
       370        380        390        400        410        420 
LLIISILVQV KQPRKKVMAC KTAFNKTGFQ EVFDPPHYEL FSLRDKEISA DLADLSEELD 
       430        440        450        460        470        480 
NYQKMRRSST ASRCIHDHHC GSQASSVKQS RTNLSSMELP FRNDFAQPQP MKTFNSTFKK 
       490        500        510        520    
SSYTFKQGHE CPEQALEDRV MEEIPCEIYV RGREDSAQAS ISIDF

Isoforms

- Isoform 2 of Neuropilin and tolloid-like protein 2 - Isoform 3 of Neuropilin and tolloid-like protein 2

Sequence View

        10         20         30         40         50         60 
MALERLCSVL KVLLITVLVV EGIAVAQKTQ DGQNIGIKHI PATQCGIWVR TSNGGHFASP 
        70         80         90        100        110        120 
NYPDSYPPNK ECIYILEAAP RQRIELTFDE HYYIEPSFEC RFDHLEVRDG PFGFSPLIDR 
       130        140        150        160        170        180 
YCGVKSPPLI RSTGRFMWIK FSSDEELEGL GFRAKYSFIP DPDFTYLGGI LNPIPDCQFE 
       190        200        210        220        230        240 
LSGADGIVRS SQVEQEEKTK PGQAVDCIWT IKATPKAKIY LRFLDYQMEH SNECKRNFVA 
       250        260        270        280        290        300 
VYDGSSSIEN LKAKFCSTVA NDVMLKTGIG VIRMWADEGS RLSRFRMLFT SFVEPPCTSS 
       310        320        330        340        350        360 
TFFCHSNMCI NNSLVCNGVQ NCAYPWDENH CKEKKKAGVF EQITKTHGTI IGITSGIVLV 
       370        380        390        400        410        420 
LLIISILVQV KQPRKKVMAC KTAFNKTGFQ EVFDPPHYEL FSLRDKEISA DLADLSEELD 
       430        440        450        460        470        480 
NYQKMRRSST ASRCIHDHHC GSQASSVKQS RTNLSSMELP FRNDFAQPQP MKTFNSTFKK 
       490        500        510        520    
SSYTFKQGHE CPEQALEDRV MEEIPCEIYV RGREDSAQAS ISIDF         10         20         30         40         50         60 
MALERLCSVL KVLLITVLVV EGIAVAQKTQ DGQNIGIKHI PATQCGIWVR TSNGGHFASP 
        70         80         90        100        110        120 
NYPDSYPPNK ECIYILEAAP RQRIELTFDE HYYIEPSFEC RFDHLEVRDG PFGFSPLIDR 
       130        140        150        160        170        180 
YCGVKSPPLI RSTGRFMWIK FSSDEELEGL GFRAKYSFIP DPDFTYLGGI LNPIPDCQFE 
       190        200        210        220        230        240 
LSGADGIVRS SQVEQEEKTK PGQAVDCIWT IKATPKAKIY LRFLDYQMEH SNECKRNFVA 
       250        260        270        280        290        300 
VYDGSSSIEN LKAKFCSTVA NDVMLKTGIG VIRMWADEGS RLSRFRMLFT SFVEPPCTSS 
       310        320        330        340        350        360 
TFFCHSNMCI NNSLVCNGVQ NCAYPWDENH CKEKKKAGVF EQITKTHGTI IGITSGIVLV 
       370        380        390        400        410        420 
LLIISILVQV KQPRKKVMAC KTAFNKTGFQ EVFDPPHYEL FSLRDKEISA DLADLSEELD 
       430        440        450        460        470        480 
NYQKMRRSST ASRCIHDHHC GSQASSVKQS RTNLSSMELP FRNDFAQPQP MKTFNSTFKK 
       490        500        510        520    
SSYTFKQGHE CPEQALEDRV MEEIPCEIYV RGREDSAQAS ISIDF



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Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8NC67-1-unknown MALERL... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt82635
    Q8NC67-23-unknown IAVAQK... 23 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8NC67-23-unknown IAVAQK... 23 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt113349

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)