Q8NDF8: Terminal nucleotidyltransferase 4A {ECO:0000305}

General Information

Protein names	- Terminal nucleotidyltransferase 4A {ECO:0000305} - Non-canonical poly(A) RNA polymerase PAPD5 {ECO:0000305} - 2.7.7.19 {ECO:0000269\|PubMed:21788334} - PAP-associated domain-containing protein 5 - Terminal guanylyltransferase {ECO:0000305} - 2.7.7.- {ECO:0000269\|PubMed:30026317} - Terminal nucleotidyltransferase 4B {ECO:0000305} - Terminal uridylyltransferase 3 - TUTase 3 - Topoisomerase-related function protein 4-2 - TRF4-2 {ECO:0000303\|PubMed:21788334}
Gene names	PAPD5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8NDF8

1 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MYRSGERLLG SHALPAEQRD FLPLETTNNN NNHHQPGAWA RRAGSSASSP PSASSSPHPS
        70         80         90        100        110        120
AAVPAADPAD SASGSSNKRK RDNKASGGRA AGGGRADGGG VVYSGTPWKR RNYNQGVVGL
       130        140        150        160        170        180
HEEISDFYEY MSPRPEEEKM RMEVVNRIES VIKELWPSAD VQIFGSFKTG LYLPTSDIDL
       190        200        210        220        230        240
VVFGKWENLP LWTLEEALRK HKVADEDSVK VLDKATVPII KLTDSFTEVK VDISFNVQNG
       250        260        270        280        290        300
VRAADLIKDF TKKYPVLPYL VLVLKQFLLQ RDLNEVFTGG IGSYSLFLMA VSFLQLHPRE
       310        320        330        340        350        360
DACIPNTNYG VLLIEFFELY GRHFNYLKTG IRIKDGGSYV AKDEVQKNML DGYRPSMLYI
       370        380        390        400        410        420
EDPLQPGNDV GRSSYGAMQV KQAFDYAYVV LSHAVSPIAK YYPNNETESI LGRIIRVTDE
       430        440        450        460        470        480
VATYRDWISK QWGLKNRPEP SCNGPVSSSS ATQSSSSDVD SDATPCKTPK QLLCRPSTGN
       490        500        510        520        530        540
RVGSQDVSLE SSQAVGKMQS TQTTNTSNST NKSQHGSARL FRSSSKGFQG TTQTSHGSLM
       550        560        570
TNKQHQGKSN NQYYHGKKRK HKRDAPLSDL CR

Isoforms

- Isoform 2 of Non-canonical poly(A) RNA polymerase PAPD5 - Isoform 3 of Non-canonical poly(A) RNA polymerase PAPD5 - Isoform 4 of Non-canonical poly(A) RNA polymerase PAPD5 - Isoform 5 of Non-canonical poly(A) RNA polymerase PAPD5 - Isoform 2 of Terminal nucleotidyltransferase 4B - Isoform 3 of Terminal nucleotidyltransferase 4B - Isoform 4 of Terminal nucleotidyltransferase 4B - Isoform 5 of Terminal nucleotidyltransferase 4B

Sequence View

        10         20         30         40         50         60
MYRSGERLLG SHALPAEQRD FLPLETTNNN NNHHQPGAWA RRAGSSASSP PSASSSPHPS
        70         80         90        100        110        120
AAVPAADPAD SASGSSNKRK RDNKASGGRA AGGGRADGGG VVYSGTPWKR RNYNQGVVGL
       130        140        150        160        170        180
HEEISDFYEY MSPRPEEEKM RMEVVNRIES VIKELWPSAD VQIFGSFKTG LYLPTSDIDL
       190        200        210        220        230        240
VVFGKWENLP LWTLEEALRK HKVADEDSVK VLDKATVPII KLTDSFTEVK VDISFNVQNG
       250        260        270        280        290        300
VRAADLIKDF TKKYPVLPYL VLVLKQFLLQ RDLNEVFTGG IGSYSLFLMA VSFLQLHPRE
       310        320        330        340        350        360
DACIPNTNYG VLLIEFFELY GRHFNYLKTG IRIKDGGSYV AKDEVQKNML DGYRPSMLYI
       370        380        390        400        410        420
EDPLQPGNDV GRSSYGAMQV KQAFDYAYVV LSHAVSPIAK YYPNNETESI LGRIIRVTDE
       430        440        450        460        470        480
VATYRDWISK QWGLKNRPEP SCNGPVSSSS ATQSSSSDVD SDATPCKTPK QLLCRPSTGN
       490        500        510        520        530        540
RVGSQDVSLE SSQAVGKMQS TQTTNTSNST NKSQHGSARL FRSSSKGFQG TTQTSHGSLM
       550        560        570
TNKQHQGKSN NQYYHGKKRK HKRDAPLSDL CR         10         20         30         40         50         60
MYRSGERLLG SHALPAEQRD FLPLETTNNN NNHHQPGAWA RRAGSSASSP PSASSSPHPS
        70         80         90        100        110        120
AAVPAADPAD SASGSSNKRK RDNKASGGRA AGGGRADGGG VVYSGTPWKR RNYNQGVVGL
       130        140        150        160        170        180
HEEISDFYEY MSPRPEEEKM RMEVVNRIES VIKELWPSAD VQIFGSFKTG LYLPTSDIDL
       190        200        210        220        230        240
VVFGKWENLP LWTLEEALRK HKVADEDSVK VLDKATVPII KLTDSFTEVK VDISFNVQNG
       250        260        270        280        290        300
VRAADLIKDF TKKYPVLPYL VLVLKQFLLQ RDLNEVFTGG IGSYSLFLMA VSFLQLHPRE
       310        320        330        340        350        360
DACIPNTNYG VLLIEFFELY GRHFNYLKTG IRIKDGGSYV AKDEVQKNML DGYRPSMLYI
       370        380        390        400        410        420
EDPLQPGNDV GRSSYGAMQV KQAFDYAYVV LSHAVSPIAK YYPNNETESI LGRIIRVTDE
       430        440        450        460        470        480
VATYRDWISK QWGLKNRPEP SCNGPVSSSS ATQSSSSDVD SDATPCKTPK QLLCRPSTGN
       490        500        510        520        530        540
RVGSQDVSLE SSQAVGKMQS TQTTNTSNST NKSQHGSARL FRSSSKGFQG TTQTSHGSLM
       550        560        570
TNKQHQGKSN NQYYHGKKRK HKRDAPLSDL CR         10         20         30         40         50         60
MYRSGERLLG SHALPAEQRD FLPLETTNNN NNHHQPGAWA RRAGSSASSP PSASSSPHPS
        70         80         90        100        110        120
AAVPAADPAD SASGSSNKRK RDNKASGGRA AGGGRADGGG VVYSGTPWKR RNYNQGVVGL
       130        140        150        160        170        180
HEEISDFYEY MSPRPEEEKM RMEVVNRIES VIKELWPSAD VQIFGSFKTG LYLPTSDIDL
       190        200        210        220        230        240
VVFGKWENLP LWTLEEALRK HKVADEDSVK VLDKATVPII KLTDSFTEVK VDISFNVQNG
       250        260        270        280        290        300
VRAADLIKDF TKKYPVLPYL VLVLKQFLLQ RDLNEVFTGG IGSYSLFLMA VSFLQLHPRE
       310        320        330        340        350        360
DACIPNTNYG VLLIEFFELY GRHFNYLKTG IRIKDGGSYV AKDEVQKNML DGYRPSMLYI
       370        380        390        400        410        420
EDPLQPGNDV GRSSYGAMQV KQAFDYAYVV LSHAVSPIAK YYPNNETESI LGRIIRVTDE
       430        440        450        460        470        480
VATYRDWISK QWGLKNRPEP SCNGPVSSSS ATQSSSSDVD SDATPCKTPK QLLCRPSTGN
       490        500        510        520        530        540
RVGSQDVSLE SSQAVGKMQS TQTTNTSNST NKSQHGSARL FRSSSKGFQG TTQTSHGSLM
       550        560        570
TNKQHQGKSN NQYYHGKKRK HKRDAPLSDL CR         10         20         30         40         50         60
MYRSGERLLG SHALPAEQRD FLPLETTNNN NNHHQPGAWA RRAGSSASSP PSASSSPHPS
        70         80         90        100        110        120
AAVPAADPAD SASGSSNKRK RDNKASGGRA AGGGRADGGG VVYSGTPWKR RNYNQGVVGL
       130        140        150        160        170        180
HEEISDFYEY MSPRPEEEKM RMEVVNRIES VIKELWPSAD VQIFGSFKTG LYLPTSDIDL
       190        200        210        220        230        240
VVFGKWENLP LWTLEEALRK HKVADEDSVK VLDKATVPII KLTDSFTEVK VDISFNVQNG
       250        260        270        280        290        300
VRAADLIKDF TKKYPVLPYL VLVLKQFLLQ RDLNEVFTGG IGSYSLFLMA VSFLQLHPRE
       310        320        330        340        350        360
DACIPNTNYG VLLIEFFELY GRHFNYLKTG IRIKDGGSYV AKDEVQKNML DGYRPSMLYI
       370        380        390        400        410        420
EDPLQPGNDV GRSSYGAMQV KQAFDYAYVV LSHAVSPIAK YYPNNETESI LGRIIRVTDE
       430        440        450        460        470        480
VATYRDWISK QWGLKNRPEP SCNGPVSSSS ATQSSSSDVD SDATPCKTPK QLLCRPSTGN
       490        500        510        520        530        540
RVGSQDVSLE SSQAVGKMQS TQTTNTSNST NKSQHGSARL FRSSSKGFQG TTQTSHGSLM
       550        560        570
TNKQHQGKSN NQYYHGKKRK HKRDAPLSDL CR         10         20         30         40         50         60
MYRSGERLLG SHALPAEQRD FLPLETTNNN NNHHQPGAWA RRAGSSASSP PSASSSPHPS
        70         80         90        100        110        120
AAVPAADPAD SASGSSNKRK RDNKASGGRA AGGGRADGGG VVYSGTPWKR RNYNQGVVGL
       130        140        150        160        170        180
HEEISDFYEY MSPRPEEEKM RMEVVNRIES VIKELWPSAD VQIFGSFKTG LYLPTSDIDL
       190        200        210        220        230        240
VVFGKWENLP LWTLEEALRK HKVADEDSVK VLDKATVPII KLTDSFTEVK VDISFNVQNG
       250        260        270        280        290        300
VRAADLIKDF TKKYPVLPYL VLVLKQFLLQ RDLNEVFTGG IGSYSLFLMA VSFLQLHPRE
       310        320        330        340        350        360
DACIPNTNYG VLLIEFFELY GRHFNYLKTG IRIKDGGSYV AKDEVQKNML DGYRPSMLYI
       370        380        390        400        410        420
EDPLQPGNDV GRSSYGAMQV KQAFDYAYVV LSHAVSPIAK YYPNNETESI LGRIIRVTDE
       430        440        450        460        470        480
VATYRDWISK QWGLKNRPEP SCNGPVSSSS ATQSSSSDVD SDATPCKTPK QLLCRPSTGN
       490        500        510        520        530        540
RVGSQDVSLE SSQAVGKMQS TQTTNTSNST NKSQHGSARL FRSSSKGFQG TTQTSHGSLM
       550        560        570
TNKQHQGKSN NQYYHGKKRK HKRDAPLSDL CR         10         20         30         40         50         60
MYRSGERLLG SHALPAEQRD FLPLETTNNN NNHHQPGAWA RRAGSSASSP PSASSSPHPS
        70         80         90        100        110        120
AAVPAADPAD SASGSSNKRK RDNKASGGRA AGGGRADGGG VVYSGTPWKR RNYNQGVVGL
       130        140        150        160        170        180
HEEISDFYEY MSPRPEEEKM RMEVVNRIES VIKELWPSAD VQIFGSFKTG LYLPTSDIDL
       190        200        210        220        230        240
VVFGKWENLP LWTLEEALRK HKVADEDSVK VLDKATVPII KLTDSFTEVK VDISFNVQNG
       250        260        270        280        290        300
VRAADLIKDF TKKYPVLPYL VLVLKQFLLQ RDLNEVFTGG IGSYSLFLMA VSFLQLHPRE
       310        320        330        340        350        360
DACIPNTNYG VLLIEFFELY GRHFNYLKTG IRIKDGGSYV AKDEVQKNML DGYRPSMLYI
       370        380        390        400        410        420
EDPLQPGNDV GRSSYGAMQV KQAFDYAYVV LSHAVSPIAK YYPNNETESI LGRIIRVTDE
       430        440        450        460        470        480
VATYRDWISK QWGLKNRPEP SCNGPVSSSS ATQSSSSDVD SDATPCKTPK QLLCRPSTGN
       490        500        510        520        530        540
RVGSQDVSLE SSQAVGKMQS TQTTNTSNST NKSQHGSARL FRSSSKGFQG TTQTSHGSLM
       550        560        570
TNKQHQGKSN NQYYHGKKRK HKRDAPLSDL CR         10         20         30         40         50         60
MYRSGERLLG SHALPAEQRD FLPLETTNNN NNHHQPGAWA RRAGSSASSP PSASSSPHPS
        70         80         90        100        110        120
AAVPAADPAD SASGSSNKRK RDNKASGGRA AGGGRADGGG VVYSGTPWKR RNYNQGVVGL
       130        140        150        160        170        180
HEEISDFYEY MSPRPEEEKM RMEVVNRIES VIKELWPSAD VQIFGSFKTG LYLPTSDIDL
       190        200        210        220        230        240
VVFGKWENLP LWTLEEALRK HKVADEDSVK VLDKATVPII KLTDSFTEVK VDISFNVQNG
       250        260        270        280        290        300
VRAADLIKDF TKKYPVLPYL VLVLKQFLLQ RDLNEVFTGG IGSYSLFLMA VSFLQLHPRE
       310        320        330        340        350        360
DACIPNTNYG VLLIEFFELY GRHFNYLKTG IRIKDGGSYV AKDEVQKNML DGYRPSMLYI
       370        380        390        400        410        420
EDPLQPGNDV GRSSYGAMQV KQAFDYAYVV LSHAVSPIAK YYPNNETESI LGRIIRVTDE
       430        440        450        460        470        480
VATYRDWISK QWGLKNRPEP SCNGPVSSSS ATQSSSSDVD SDATPCKTPK QLLCRPSTGN
       490        500        510        520        530        540
RVGSQDVSLE SSQAVGKMQS TQTTNTSNST NKSQHGSARL FRSSSKGFQG TTQTSHGSLM
       550        560        570
TNKQHQGKSN NQYYHGKKRK HKRDAPLSDL CR         10         20         30         40         50         60
MYRSGERLLG SHALPAEQRD FLPLETTNNN NNHHQPGAWA RRAGSSASSP PSASSSPHPS
        70         80         90        100        110        120
AAVPAADPAD SASGSSNKRK RDNKASGGRA AGGGRADGGG VVYSGTPWKR RNYNQGVVGL
       130        140        150        160        170        180
HEEISDFYEY MSPRPEEEKM RMEVVNRIES VIKELWPSAD VQIFGSFKTG LYLPTSDIDL
       190        200        210        220        230        240
VVFGKWENLP LWTLEEALRK HKVADEDSVK VLDKATVPII KLTDSFTEVK VDISFNVQNG
       250        260        270        280        290        300
VRAADLIKDF TKKYPVLPYL VLVLKQFLLQ RDLNEVFTGG IGSYSLFLMA VSFLQLHPRE
       310        320        330        340        350        360
DACIPNTNYG VLLIEFFELY GRHFNYLKTG IRIKDGGSYV AKDEVQKNML DGYRPSMLYI
       370        380        390        400        410        420
EDPLQPGNDV GRSSYGAMQV KQAFDYAYVV LSHAVSPIAK YYPNNETESI LGRIIRVTDE
       430        440        450        460        470        480
VATYRDWISK QWGLKNRPEP SCNGPVSSSS ATQSSSSDVD SDATPCKTPK QLLCRPSTGN
       490        500        510        520        530        540
RVGSQDVSLE SSQAVGKMQS TQTTNTSNST NKSQHGSARL FRSSSKGFQG TTQTSHGSLM
       550        560        570
TNKQHQGKSN NQYYHGKKRK HKRDAPLSDL CR

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q8NDF8-1-unknown	MYRSGE...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8NDF8-1-unknown	MYRSGE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84243
Q8NDF8-1-unknown	MYRSGE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84244
Q8NDF8-1-unknown	MYRSGE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84245
Q8NDF8-1-unknown	MYRSGE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt96988

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TSHGSL	538	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79862
...TSHGSL	538	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93100
...SDLCR	572	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SDLCR	572	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79864

TopFIND

Q8NDF8: Terminal nucleotidyltransferase 4A {ECO:0000305}

General Information

1

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

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Methodology:

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Protein Neighborhood

Domains & Features

1 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates