Q8NEY8: Periphilin-1 {ECO:0000303|PubMed:12853457}

General Information

Protein names	- Periphilin-1 {ECO:0000303\|PubMed:12853457} - CDC7 expression repressor {ECO:0000303\|PubMed:15474462} - CR {ECO:0000303\|PubMed:15474462} - Gastric cancer antigen Ga50 {ECO:0000303\|PubMed:12087473}
Gene names	PPHLN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8NEY8

2 N-termini

5 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Periphilin-1 - Isoform 3 of Periphilin-1 - Isoform 5 of Periphilin-1 - Isoform 6 of Periphilin-1 - Isoform 7 of Periphilin-1 - Isoform 8 of Periphilin-1 - Isoform 9 of Periphilin-1

Sequence View

        10         20         30         40         50         60
MWSEGRYEYE RIPRERAPPR SHPSDGYNRL VNIVPKKPPL LDRPGEGSYN RYYSHVDYRD
        70         80         90        100        110        120
YDEGRSFSHD RRSGPPHRGD ESGYRWTRDD HSASRQPEYR DMRDGFRRKS FYSSHYARER
       130        140        150        160        170        180
SPYKRDNTFF RESPVGRKDS PHSRSGSSVS SRSYSPERSK SYSFHQSQHR KSVRPGASYK
       190        200        210        220        230        240
RQNEGNPERD KERPVQSLKT SRDTSPSSGS AVSSSKVLDK PSRLTEKELA EAASKWAAEK
       250        260        270        280        290        300
LEKSDESNLP EISEYEAGST APLFTDQPEE PESNTTHGIE LFEDSQLTTR SKAIASKTKE
       310        320        330        340        350        360
IEQVYRQDCE TFGMVVKMLI EKDPSLEKSI QFALRQNLHE IESAGQTWQQ VPPVRNTEMD
       370        380        390        400        410        420
HDGTPENEGE ETAQSAPQPP QAPQPLQPRK KRVRRTTQLR RTTGAPDITW GMLKKTTQEA
       430        440        450
ERILLRTQTP FTPENLFLAM LSVVHCNSRK DVKPENKQ         10         20         30         40         50         60
MWSEGRYEYE RIPRERAPPR SHPSDGYNRL VNIVPKKPPL LDRPGEGSYN RYYSHVDYRD
        70         80         90        100        110        120
YDEGRSFSHD RRSGPPHRGD ESGYRWTRDD HSASRQPEYR DMRDGFRRKS FYSSHYARER
       130        140        150        160        170        180
SPYKRDNTFF RESPVGRKDS PHSRSGSSVS SRSYSPERSK SYSFHQSQHR KSVRPGASYK
       190        200        210        220        230        240
RQNEGNPERD KERPVQSLKT SRDTSPSSGS AVSSSKVLDK PSRLTEKELA EAASKWAAEK
       250        260        270        280        290        300
LEKSDESNLP EISEYEAGST APLFTDQPEE PESNTTHGIE LFEDSQLTTR SKAIASKTKE
       310        320        330        340        350        360
IEQVYRQDCE TFGMVVKMLI EKDPSLEKSI QFALRQNLHE IESAGQTWQQ VPPVRNTEMD
       370        380        390        400        410        420
HDGTPENEGE ETAQSAPQPP QAPQPLQPRK KRVRRTTQLR RTTGAPDITW GMLKKTTQEA
       430        440        450
ERILLRTQTP FTPENLFLAM LSVVHCNSRK DVKPENKQ         10         20         30         40         50         60
MWSEGRYEYE RIPRERAPPR SHPSDGYNRL VNIVPKKPPL LDRPGEGSYN RYYSHVDYRD
        70         80         90        100        110        120
YDEGRSFSHD RRSGPPHRGD ESGYRWTRDD HSASRQPEYR DMRDGFRRKS FYSSHYARER
       130        140        150        160        170        180
SPYKRDNTFF RESPVGRKDS PHSRSGSSVS SRSYSPERSK SYSFHQSQHR KSVRPGASYK
       190        200        210        220        230        240
RQNEGNPERD KERPVQSLKT SRDTSPSSGS AVSSSKVLDK PSRLTEKELA EAASKWAAEK
       250        260        270        280        290        300
LEKSDESNLP EISEYEAGST APLFTDQPEE PESNTTHGIE LFEDSQLTTR SKAIASKTKE
       310        320        330        340        350        360
IEQVYRQDCE TFGMVVKMLI EKDPSLEKSI QFALRQNLHE IESAGQTWQQ VPPVRNTEMD
       370        380        390        400        410        420
HDGTPENEGE ETAQSAPQPP QAPQPLQPRK KRVRRTTQLR RTTGAPDITW GMLKKTTQEA
       430        440        450
ERILLRTQTP FTPENLFLAM LSVVHCNSRK DVKPENKQ         10         20         30         40         50         60
MWSEGRYEYE RIPRERAPPR SHPSDGYNRL VNIVPKKPPL LDRPGEGSYN RYYSHVDYRD
        70         80         90        100        110        120
YDEGRSFSHD RRSGPPHRGD ESGYRWTRDD HSASRQPEYR DMRDGFRRKS FYSSHYARER
       130        140        150        160        170        180
SPYKRDNTFF RESPVGRKDS PHSRSGSSVS SRSYSPERSK SYSFHQSQHR KSVRPGASYK
       190        200        210        220        230        240
RQNEGNPERD KERPVQSLKT SRDTSPSSGS AVSSSKVLDK PSRLTEKELA EAASKWAAEK
       250        260        270        280        290        300
LEKSDESNLP EISEYEAGST APLFTDQPEE PESNTTHGIE LFEDSQLTTR SKAIASKTKE
       310        320        330        340        350        360
IEQVYRQDCE TFGMVVKMLI EKDPSLEKSI QFALRQNLHE IESAGQTWQQ VPPVRNTEMD
       370        380        390        400        410        420
HDGTPENEGE ETAQSAPQPP QAPQPLQPRK KRVRRTTQLR RTTGAPDITW GMLKKTTQEA
       430        440        450
ERILLRTQTP FTPENLFLAM LSVVHCNSRK DVKPENKQ         10         20         30         40         50         60
MWSEGRYEYE RIPRERAPPR SHPSDGYNRL VNIVPKKPPL LDRPGEGSYN RYYSHVDYRD
        70         80         90        100        110        120
YDEGRSFSHD RRSGPPHRGD ESGYRWTRDD HSASRQPEYR DMRDGFRRKS FYSSHYARER
       130        140        150        160        170        180
SPYKRDNTFF RESPVGRKDS PHSRSGSSVS SRSYSPERSK SYSFHQSQHR KSVRPGASYK
       190        200        210        220        230        240
RQNEGNPERD KERPVQSLKT SRDTSPSSGS AVSSSKVLDK PSRLTEKELA EAASKWAAEK
       250        260        270        280        290        300
LEKSDESNLP EISEYEAGST APLFTDQPEE PESNTTHGIE LFEDSQLTTR SKAIASKTKE
       310        320        330        340        350        360
IEQVYRQDCE TFGMVVKMLI EKDPSLEKSI QFALRQNLHE IESAGQTWQQ VPPVRNTEMD
       370        380        390        400        410        420
HDGTPENEGE ETAQSAPQPP QAPQPLQPRK KRVRRTTQLR RTTGAPDITW GMLKKTTQEA
       430        440        450
ERILLRTQTP FTPENLFLAM LSVVHCNSRK DVKPENKQ         10         20         30         40         50         60
MWSEGRYEYE RIPRERAPPR SHPSDGYNRL VNIVPKKPPL LDRPGEGSYN RYYSHVDYRD
        70         80         90        100        110        120
YDEGRSFSHD RRSGPPHRGD ESGYRWTRDD HSASRQPEYR DMRDGFRRKS FYSSHYARER
       130        140        150        160        170        180
SPYKRDNTFF RESPVGRKDS PHSRSGSSVS SRSYSPERSK SYSFHQSQHR KSVRPGASYK
       190        200        210        220        230        240
RQNEGNPERD KERPVQSLKT SRDTSPSSGS AVSSSKVLDK PSRLTEKELA EAASKWAAEK
       250        260        270        280        290        300
LEKSDESNLP EISEYEAGST APLFTDQPEE PESNTTHGIE LFEDSQLTTR SKAIASKTKE
       310        320        330        340        350        360
IEQVYRQDCE TFGMVVKMLI EKDPSLEKSI QFALRQNLHE IESAGQTWQQ VPPVRNTEMD
       370        380        390        400        410        420
HDGTPENEGE ETAQSAPQPP QAPQPLQPRK KRVRRTTQLR RTTGAPDITW GMLKKTTQEA
       430        440        450
ERILLRTQTP FTPENLFLAM LSVVHCNSRK DVKPENKQ         10         20         30         40         50         60
MWSEGRYEYE RIPRERAPPR SHPSDGYNRL VNIVPKKPPL LDRPGEGSYN RYYSHVDYRD
        70         80         90        100        110        120
YDEGRSFSHD RRSGPPHRGD ESGYRWTRDD HSASRQPEYR DMRDGFRRKS FYSSHYARER
       130        140        150        160        170        180
SPYKRDNTFF RESPVGRKDS PHSRSGSSVS SRSYSPERSK SYSFHQSQHR KSVRPGASYK
       190        200        210        220        230        240
RQNEGNPERD KERPVQSLKT SRDTSPSSGS AVSSSKVLDK PSRLTEKELA EAASKWAAEK
       250        260        270        280        290        300
LEKSDESNLP EISEYEAGST APLFTDQPEE PESNTTHGIE LFEDSQLTTR SKAIASKTKE
       310        320        330        340        350        360
IEQVYRQDCE TFGMVVKMLI EKDPSLEKSI QFALRQNLHE IESAGQTWQQ VPPVRNTEMD
       370        380        390        400        410        420
HDGTPENEGE ETAQSAPQPP QAPQPLQPRK KRVRRTTQLR RTTGAPDITW GMLKKTTQEA
       430        440        450
ERILLRTQTP FTPENLFLAM LSVVHCNSRK DVKPENKQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 5 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q8NEY8-1-unknown	MWSEGR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8NEY8-1-unknown	MWSEGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85948
Q8NEY8-1-unknown	MWSEGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85952
Q8NEY8-1-unknown	MWSEGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85953
Q8NEY8-1-unknown	MWSEGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99269
Q8NEY8-1-unknown	MWSEGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99270
Q8NEY8-1-unknown	MWSEGR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99271
Q8NEY8-102-unknown	MRDGFR...	102	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000256678
Q8NEY8-102-unknown	MRDGFR...	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197002
Q8NEY8-102-unknown	MRDGFR...	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197000
Q8NEY8-102-unknown	MRDGFR...	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197001
Q8NEY8-102-unknown	MRDGFR...	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196998
Q8NEY8-102-unknown	MRDGFR...	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196999
Q8NEY8-102-unknown	MRDGFR...	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197003

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...GEGSYN	49	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000449031
...GEGSYN	49	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt153888
...GEGSYN	49	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt153889
...GEGSYN	49	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt153890
...SSRSYS	154	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000450274
...SSRSYS	154	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155015
...SSRSYS	154	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155013
...SSRSYS	154	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155014
...SSRSYS	154	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155011
...SSRSYS	154	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155012
...SSRSYS	154	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155016
...FHQSQH	168	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000449772
...FHQSQH	168	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155246
...FHQSQH	168	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155244
...FHQSQH	168	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155245
...FHQSQH	168	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155242
...FHQSQH	168	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155243
...FHQSQH	168	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt155247
...PENKQ	458	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...PENKQ	458	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt81566
...PENKQ	458		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...PENKQ	458		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...PENKQ	458		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...PENKQ	458		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)