Q8NFF2: Sodium/potassium/calcium exchanger 4

General Information

Protein names	- Sodium/potassium/calcium exchanger 4 - Na(+)/K(+)/Ca(2+)-exchange protein 4 - Solute carrier family 24 member 4
Gene names	SLC24A4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8NFF2

5 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Sodium/potassium/calcium exchanger 4 - Isoform 3 of Sodium/potassium/calcium exchanger 4 - Isoform 4 of Sodium/potassium/calcium exchanger 4

Sequence View

        10         20         30         40         50         60
MALRGTLRPL KVRRRREMLP QQVGFVCAVL ALVCCASGLF GSLGHKTASA SKRVLPDTWR
        70         80         90        100        110        120
NRKLMAPVNG TQTAKNCTDP AIHEFPTDLF SNKERQHGAV LLHILGALYM FYALAIVCDD
       130        140        150        160        170        180
FFVPSLEKIC ERLHLSEDVA GATFMAAGSS TPELFASVIG VFITHGDVGV GTIVGSAVFN
       190        200        210        220        230        240
ILCIIGVCGL FAGQVVRLTW WAVCRDSVYY TISVIVLIVF IYDEQIVWWE GLVLIILYVF
       250        260        270        280        290        300
YILIMKYNVK MQAFFTVKQK SIANGNPVNS ELEAGNDFYD GSYDDPSVPL LGQVKEKPQY
       310        320        330        340        350        360
GKNPVVMVDE IMSSSPPKFT FPEAGLRIMI TNKFGPRTRL RMASRIIINE RQRLINSANG
       370        380        390        400        410        420
VSSKPLQNGR HENIENGNVP VENPEDPQQN QEQQPPPQPP PPEPEPVEAD FLSPFSVPEA
       430        440        450        460        470        480
RGDKVKWVFT WPLIFLLCVT IPNCSKPRWE KFFMVTFITA TLWIAVFSYI MVWLVTIIGY
       490        500        510        520        530        540
TLGIPDVIMG ITFLAAGTSV PDCMASLIVA RQGLGDMAVS NTIGSNVFDI LVGLGVPWGL
       550        560        570        580        590        600
QTMVVNYGST VKINSRGLVY SVVLLLGSVA LTVLGIHLNK WRLDRKLGVY VLVLYAIFLC
       610        620
FSIMIEFNVF TFVNLPMCRE DD         10         20         30         40         50         60
MALRGTLRPL KVRRRREMLP QQVGFVCAVL ALVCCASGLF GSLGHKTASA SKRVLPDTWR
        70         80         90        100        110        120
NRKLMAPVNG TQTAKNCTDP AIHEFPTDLF SNKERQHGAV LLHILGALYM FYALAIVCDD
       130        140        150        160        170        180
FFVPSLEKIC ERLHLSEDVA GATFMAAGSS TPELFASVIG VFITHGDVGV GTIVGSAVFN
       190        200        210        220        230        240
ILCIIGVCGL FAGQVVRLTW WAVCRDSVYY TISVIVLIVF IYDEQIVWWE GLVLIILYVF
       250        260        270        280        290        300
YILIMKYNVK MQAFFTVKQK SIANGNPVNS ELEAGNDFYD GSYDDPSVPL LGQVKEKPQY
       310        320        330        340        350        360
GKNPVVMVDE IMSSSPPKFT FPEAGLRIMI TNKFGPRTRL RMASRIIINE RQRLINSANG
       370        380        390        400        410        420
VSSKPLQNGR HENIENGNVP VENPEDPQQN QEQQPPPQPP PPEPEPVEAD FLSPFSVPEA
       430        440        450        460        470        480
RGDKVKWVFT WPLIFLLCVT IPNCSKPRWE KFFMVTFITA TLWIAVFSYI MVWLVTIIGY
       490        500        510        520        530        540
TLGIPDVIMG ITFLAAGTSV PDCMASLIVA RQGLGDMAVS NTIGSNVFDI LVGLGVPWGL
       550        560        570        580        590        600
QTMVVNYGST VKINSRGLVY SVVLLLGSVA LTVLGIHLNK WRLDRKLGVY VLVLYAIFLC
       610        620
FSIMIEFNVF TFVNLPMCRE DD         10         20         30         40         50         60
MALRGTLRPL KVRRRREMLP QQVGFVCAVL ALVCCASGLF GSLGHKTASA SKRVLPDTWR
        70         80         90        100        110        120
NRKLMAPVNG TQTAKNCTDP AIHEFPTDLF SNKERQHGAV LLHILGALYM FYALAIVCDD
       130        140        150        160        170        180
FFVPSLEKIC ERLHLSEDVA GATFMAAGSS TPELFASVIG VFITHGDVGV GTIVGSAVFN
       190        200        210        220        230        240
ILCIIGVCGL FAGQVVRLTW WAVCRDSVYY TISVIVLIVF IYDEQIVWWE GLVLIILYVF
       250        260        270        280        290        300
YILIMKYNVK MQAFFTVKQK SIANGNPVNS ELEAGNDFYD GSYDDPSVPL LGQVKEKPQY
       310        320        330        340        350        360
GKNPVVMVDE IMSSSPPKFT FPEAGLRIMI TNKFGPRTRL RMASRIIINE RQRLINSANG
       370        380        390        400        410        420
VSSKPLQNGR HENIENGNVP VENPEDPQQN QEQQPPPQPP PPEPEPVEAD FLSPFSVPEA
       430        440        450        460        470        480
RGDKVKWVFT WPLIFLLCVT IPNCSKPRWE KFFMVTFITA TLWIAVFSYI MVWLVTIIGY
       490        500        510        520        530        540
TLGIPDVIMG ITFLAAGTSV PDCMASLIVA RQGLGDMAVS NTIGSNVFDI LVGLGVPWGL
       550        560        570        580        590        600
QTMVVNYGST VKINSRGLVY SVVLLLGSVA LTVLGIHLNK WRLDRKLGVY VLVLYAIFLC
       610        620
FSIMIEFNVF TFVNLPMCRE DD

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q8NFF2-1-unknown	MALRGT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82395
Q8NFF2-18-unknown	MLPQQV...	18	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000298877
Q8NFF2-18-unknown	MLPQQV...	18	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000337789
Q8NFF2-18-unknown	MLPQQV...	18	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt132765
Q8NFF2-39-unknown	LFGSLG...	39	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8NFF2-39-unknown	LFGSLG...	39	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115366
Q8NFF2-65-unknown	MAPVNG...	65	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82394
Q8NFF2-65-unknown	MAPVNG...	65	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000376948
Q8NFF2-65-unknown	MAPVNG...	65	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt108068
Q8NFF2-110-unknown	MFYALA...	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82396
Q8NFF2-110-unknown	MFYALA...	110	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452099
Q8NFF2-110-unknown	MFYALA...	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt108156
Q8NFF2-110-unknown	MFYALA...	110	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt108155

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GVGTIV	173	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452099
...GVGTIV	173	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt114701
...GVGTIV	173	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt114699
...GVGTIV	173	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt114700
...CREDD	622	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...CREDD	622	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78014
...CREDD	622	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78012
...CREDD	622	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78013

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)