TopFIND 4.0

Q8NFG4: Folliculin

General Information

Protein names
- Folliculin
- BHD skin lesion fibrofolliculoma protein
- Birt-Hogg-Dube syndrome protein
Gene names FLCN
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q8NFG4

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MNAIVALCHF CELHGPRTLF CTEVLHAPLP QGDGNEDSPG QGEQAEEEEG GIQMNSRMRA 
        70         80         90        100        110        120 
HSPAEGASVE SSSPGPKKSD MCEGCRSLAA GHPGYISHDK ETSIKYVSHQ HPSHPQLFSI 
       130        140        150        160        170        180 
VRQACVRSLS CEVCPGREGP IFFGDEQHGF VFSHTFFIKD SLARGFQRWY SIITIMMDRI 
       190        200        210        220        230        240 
YLINSWPFLL GKVRGIIDEL QGKALKVFEA EQFGCPQRAQ RMNTAFTPFL HQRNGNAARS 
       250        260        270        280        290        300 
LTSLTSDDNL WACLHTSFAW LLKACGSRLT EKLLEGAPTE DTLVQMEKLA DLEEESESWD 
       310        320        330        340        350        360 
NSEAEEEEKA PVLPESTEGR ELTQGPAESS SLSGCGSWQP RKLPVFKSLR HMRQVLGAPS 
       370        380        390        400        410        420 
FRMLAWHVLM GNQVIWKSRD VDLVQSAFEV LRTMLPVGCV RIIPYSSQYE EAYRCNFLGL 
       430        440        450        460        470        480 
SPHVQIPPHV LSSEFAVIVE VHAAARSTLH PVGCEDDQSL SKYEFVVTSG SPVAADRVGP 
       490        500        510        520        530        540 
TILNKIEAAL TNQNLSVDVV DQCLVCLKEE WMNKVKVLFK FTKVDSRPKE DTQKLLSILG 
       550        560        570    
ASEEDNVKLL KFWMTGLSKT YKSHLMSTVR SPTASESRN

Isoforms

- Isoform 2 of Folliculin - Isoform 3 of Folliculin

Sequence View

        10         20         30         40         50         60 
MNAIVALCHF CELHGPRTLF CTEVLHAPLP QGDGNEDSPG QGEQAEEEEG GIQMNSRMRA 
        70         80         90        100        110        120 
HSPAEGASVE SSSPGPKKSD MCEGCRSLAA GHPGYISHDK ETSIKYVSHQ HPSHPQLFSI 
       130        140        150        160        170        180 
VRQACVRSLS CEVCPGREGP IFFGDEQHGF VFSHTFFIKD SLARGFQRWY SIITIMMDRI 
       190        200        210        220        230        240 
YLINSWPFLL GKVRGIIDEL QGKALKVFEA EQFGCPQRAQ RMNTAFTPFL HQRNGNAARS 
       250        260        270        280        290        300 
LTSLTSDDNL WACLHTSFAW LLKACGSRLT EKLLEGAPTE DTLVQMEKLA DLEEESESWD 
       310        320        330        340        350        360 
NSEAEEEEKA PVLPESTEGR ELTQGPAESS SLSGCGSWQP RKLPVFKSLR HMRQVLGAPS 
       370        380        390        400        410        420 
FRMLAWHVLM GNQVIWKSRD VDLVQSAFEV LRTMLPVGCV RIIPYSSQYE EAYRCNFLGL 
       430        440        450        460        470        480 
SPHVQIPPHV LSSEFAVIVE VHAAARSTLH PVGCEDDQSL SKYEFVVTSG SPVAADRVGP 
       490        500        510        520        530        540 
TILNKIEAAL TNQNLSVDVV DQCLVCLKEE WMNKVKVLFK FTKVDSRPKE DTQKLLSILG 
       550        560        570    
ASEEDNVKLL KFWMTGLSKT YKSHLMSTVR SPTASESRN         10         20         30         40         50         60 
MNAIVALCHF CELHGPRTLF CTEVLHAPLP QGDGNEDSPG QGEQAEEEEG GIQMNSRMRA 
        70         80         90        100        110        120 
HSPAEGASVE SSSPGPKKSD MCEGCRSLAA GHPGYISHDK ETSIKYVSHQ HPSHPQLFSI 
       130        140        150        160        170        180 
VRQACVRSLS CEVCPGREGP IFFGDEQHGF VFSHTFFIKD SLARGFQRWY SIITIMMDRI 
       190        200        210        220        230        240 
YLINSWPFLL GKVRGIIDEL QGKALKVFEA EQFGCPQRAQ RMNTAFTPFL HQRNGNAARS 
       250        260        270        280        290        300 
LTSLTSDDNL WACLHTSFAW LLKACGSRLT EKLLEGAPTE DTLVQMEKLA DLEEESESWD 
       310        320        330        340        350        360 
NSEAEEEEKA PVLPESTEGR ELTQGPAESS SLSGCGSWQP RKLPVFKSLR HMRQVLGAPS 
       370        380        390        400        410        420 
FRMLAWHVLM GNQVIWKSRD VDLVQSAFEV LRTMLPVGCV RIIPYSSQYE EAYRCNFLGL 
       430        440        450        460        470        480 
SPHVQIPPHV LSSEFAVIVE VHAAARSTLH PVGCEDDQSL SKYEFVVTSG SPVAADRVGP 
       490        500        510        520        530        540 
TILNKIEAAL TNQNLSVDVV DQCLVCLKEE WMNKVKVLFK FTKVDSRPKE DTQKLLSILG 
       550        560        570    
ASEEDNVKLL KFWMTGLSKT YKSHLMSTVR SPTASESRN



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Evidence Codes:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8NFG4-1-unknown MNAIVA... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8NFG4-1-unknown MNAIVA... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt75246
    Q8NFG4-1-unknown MNAIVA... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt75247

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...SESRN 579 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)