TopFIND 4.0

Q8NFT2: Metalloreductase STEAP2

General Information

Protein names
- Metalloreductase STEAP2
- 1.16.1.-
- Prostate cancer-associated protein 1
- Protein up-regulated in metastatic prostate cancer
- PUMPCn
- Six-transmembrane epithelial antigen of prostate 2
- SixTransMembrane protein of prostate 1
Gene names STEAP2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q8NFT2

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MESISMMGSP KSLSETFLPN GINGIKDARK VTVGVIGSGD FAKSLTIRLI RCGYHVVIGS 
        70         80         90        100        110        120 
RNPKFASEFF PHVVDVTHHE DALTKTNIIF VAIHREHYTS LWDLRHLLVG KILIDVSNNM 
       130        140        150        160        170        180 
RINQYPESNA EYLASLFPDS LIVKGFNVVS AWALQLGPKD ASRQVYICSN NIQARQQVIE 
       190        200        210        220        230        240 
LARQLNFIPI DLGSLSSARE IENLPLRLFT LWRGPVVVAI SLATFFFLYS FVRDVIHPYA 
       250        260        270        280        290        300 
RNQQSDFYKI PIEIVNKTLP IVAITLLSLV YLAGLLAAAY QLYYGTKYRR FPPWLETWLQ 
       310        320        330        340        350        360 
CRKQLGLLSF FFAMVHVAYS LCLPMRRSER YLFLNMAYQQ VHANIENSWN EEEVWRIEMY 
       370        380        390        400        410        420 
ISFGIMSLGL LSLLAVTSIP SVSNALNWRE FSFIQSTLGY VALLISTFHV LIYGWKRAFE 
       430        440        450        460        470        480 
EEYYRFYTPP NFVLALVLPS IVILGKIILF LPCISRKLKR IKKGWEKSQF LEEGMGGTIP 
       490    
HVSPERVTVM 

Isoforms

- Isoform 2 of Metalloreductase STEAP2 - Isoform 3 of Metalloreductase STEAP2

Sequence View

        10         20         30         40         50         60 
MESISMMGSP KSLSETFLPN GINGIKDARK VTVGVIGSGD FAKSLTIRLI RCGYHVVIGS 
        70         80         90        100        110        120 
RNPKFASEFF PHVVDVTHHE DALTKTNIIF VAIHREHYTS LWDLRHLLVG KILIDVSNNM 
       130        140        150        160        170        180 
RINQYPESNA EYLASLFPDS LIVKGFNVVS AWALQLGPKD ASRQVYICSN NIQARQQVIE 
       190        200        210        220        230        240 
LARQLNFIPI DLGSLSSARE IENLPLRLFT LWRGPVVVAI SLATFFFLYS FVRDVIHPYA 
       250        260        270        280        290        300 
RNQQSDFYKI PIEIVNKTLP IVAITLLSLV YLAGLLAAAY QLYYGTKYRR FPPWLETWLQ 
       310        320        330        340        350        360 
CRKQLGLLSF FFAMVHVAYS LCLPMRRSER YLFLNMAYQQ VHANIENSWN EEEVWRIEMY 
       370        380        390        400        410        420 
ISFGIMSLGL LSLLAVTSIP SVSNALNWRE FSFIQSTLGY VALLISTFHV LIYGWKRAFE 
       430        440        450        460        470        480 
EEYYRFYTPP NFVLALVLPS IVILGKIILF LPCISRKLKR IKKGWEKSQF LEEGMGGTIP 
       490    
HVSPERVTVM          10         20         30         40         50         60 
MESISMMGSP KSLSETFLPN GINGIKDARK VTVGVIGSGD FAKSLTIRLI RCGYHVVIGS 
        70         80         90        100        110        120 
RNPKFASEFF PHVVDVTHHE DALTKTNIIF VAIHREHYTS LWDLRHLLVG KILIDVSNNM 
       130        140        150        160        170        180 
RINQYPESNA EYLASLFPDS LIVKGFNVVS AWALQLGPKD ASRQVYICSN NIQARQQVIE 
       190        200        210        220        230        240 
LARQLNFIPI DLGSLSSARE IENLPLRLFT LWRGPVVVAI SLATFFFLYS FVRDVIHPYA 
       250        260        270        280        290        300 
RNQQSDFYKI PIEIVNKTLP IVAITLLSLV YLAGLLAAAY QLYYGTKYRR FPPWLETWLQ 
       310        320        330        340        350        360 
CRKQLGLLSF FFAMVHVAYS LCLPMRRSER YLFLNMAYQQ VHANIENSWN EEEVWRIEMY 
       370        380        390        400        410        420 
ISFGIMSLGL LSLLAVTSIP SVSNALNWRE FSFIQSTLGY VALLISTFHV LIYGWKRAFE 
       430        440        450        460        470        480 
EEYYRFYTPP NFVLALVLPS IVILGKIILF LPCISRKLKR IKKGWEKSQF LEEGMGGTIP 
       490    
HVSPERVTVM 



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8NFT2-1-unknown MESISM... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8NFT2-1-unknown MESISM... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt90901
    Q8NFT2-1-unknown MESISM... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt90902

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...RVTVM 490 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)