Q8NFW8: N-acylneuraminate cytidylyltransferase

General Information

Protein names	- N-acylneuraminate cytidylyltransferase - 2.7.7.43 - CMP-N-acetylneuraminic acid synthase - CMP-NeuNAc synthase
Gene names	CMAS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8NFW8

4 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDSVEKGAAT SVSNPRGRPS RGRPPKLQRN SRGGQGRGVE KPPHLAALIL ARGGSKGIPL
        70         80         90        100        110        120
KNIKHLAGVP LIGWVLRAAL DSGAFQSVWV STDHDEIENV AKQFGAQVHR RSSEVSKDSS
       130        140        150        160        170        180
TSLDAIIEFL NYHNEVDIVG NIQATSPCLH PTDLQKVAEM IREEGYDSVF SVVRRHQFRW
       190        200        210        220        230        240
SEIQKGVREV TEPLNLNPAK RPRRQDWDGE LYENGSFYFA KRHLIEMGYL QGGKMAYYEM
       250        260        270        280        290        300
RAEHSVDIDV DIDWPIAEQR VLRYGYFGKE KLKEIKLLVC NIDGCLTNGH IYVSGDQKEI
       310        320        330        340        350        360
ISYDVKDAIG ISLLKKSGIE VRLISERACS KQTLSSLKLD CKMEVSVSDK LAVVDEWRKE
       370        380        390        400        410        420
MGLCWKEVAY LGNEVSDEEC LKRVGLSGAP ADACSTAQKA VGYICKCNGG RGAIREFAEH
       430
ICLLMEKVNN SCQK

Isoforms

- Isoform 2 of N-acylneuraminate cytidylyltransferase

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8NFW8-1-Acetylation	MDSVEK...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8NFW8-1-Acetylation	MDSVEK...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8NFW8-1-Acetylation	MDSVEK...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8NFW8-1-Acetylation	MDSVEK...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107649
Q8NFW8-1-unknown	MDSVEK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82639
Q8NFW8-3-unknown	SVEKGA...	3		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178140
Q8NFW8-3-	SVEKGA...	3			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...QRVLRY	263	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt78257
	...NSCQK	434	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)