Q8NHM5: Lysine-specific demethylase 2B

General Information

Protein names	- Lysine-specific demethylase 2B - 1.14.11.27 {ECO:0000269\|PubMed:16362057, ECO:0000269\|PubMed:26237645} - CXXC-type zinc finger protein 2 - F-box and leucine-rich repeat protein 10 - F-box protein FBL10 - F-box/LRR-repeat protein 10 - JmjC domain-containing histone demethylation protein 1B - Jumonji domain-containing EMSY-interactor methyltransferase motif protein - Protein JEMMA - Protein-containing CXXC domain 2 - Histone-H3]-lysine-36 demethylase 1B
Gene names	KDM2B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8NHM5

4 N-termini

7 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Lysine-specific demethylase 2B - Isoform 3 of Lysine-specific demethylase 2B - Isoform 4 of Lysine-specific demethylase 2B - Isoform 5 of Lysine-specific demethylase 2B

Sequence View

        10         20         30         40         50         60
MAGPQMGGSA EDHPPRKRHA AEKQKKKTVI YTKCFEFESA TQRPIDRQRY DENEDLSDVE
        70         80         90        100        110        120
EIVSVRGFSL EEKLRSQLYQ GDFVHAMEGK DFNYEYVQRE ALRVPLIFRE KDGLGIKMPD
       130        140        150        160        170        180
PDFTVRDVKL LVGSRRLVDV MDVNTQKGTE MSMSQFVRYY ETPEAQRDKL YNVISLEFSH
       190        200        210        220        230        240
TKLEHLVKRP TVVDLVDWVD NMWPQHLKEK QTEATNAIAE MKYPKVKKYC LMSVKGCFTD
       250        260        270        280        290        300
FHIDFGGTSV WYHVFRGGKI FWLIPPTLHN LALYEEWVLS GKQSDIFLGD RVERCQRIEL
       310        320        330        340        350        360
KQGYTFFIPS GWIHAVYTPV DSLVFGGNIL HSFNVPMQLR IYEIEDRTRV QPKFRYPFYY
       370        380        390        400        410        420
EMCWYVLERY VYCVTQRSHL TQEYQRESML IDAPRKPSID GFSSDSWLEM EEEACDQQPQ
       430        440        450        460        470        480
EEEEKDEEGE GRDRAPKPPT DGSTSPTSTP SEDQEALGKK PKAPALRFLK RTLSNESEES
       490        500        510        520        530        540
VKSTTLAVDY PKTPTGSPAT EVSAKWTHLT EFELKGLKAL VEKLESLPEN KKCVPEGIED
       550        560        570        580        590        600
PQALLEGVKN VLKEHADDDP SLAITGVPVV TWPKKTPKNR AVGRPKGKLG PASAVKLAAN
       610        620        630        640        650        660
RTTAGARRRR TRCRKCEACL RTECGECHFC KDMKKFGGPG RMKQSCIMRQ CIAPVLPHTA
       670        680        690        700        710        720
VCLVCGEAGK EDTVEEEEGK FNLMLMECSI CNEIIHPGCL KIKESEGVVN DELPNCWECP
       730        740        750        760        770        780
KCNHAGKTGK QKRGPGFKYA SNLPGSLLKE QKMNRDNKEG QEPAKRRSEC EEAPRRRSDE
       790        800        810        820        830        840
HSKKVPPDGL LRRKSDDVHL RKKRKYEKPQ ELSGRKRASS LQTSPGSSSH LSPRPPLGSS
       850        860        870        880        890        900
LSPWWRSSLT YFQQQLKPGK EDKLFRKKRR SWKNAEDRMA LANKPLRRFK QEPEDELPEA
       910        920        930        940        950        960
PPKTRESDHS RSSSPTAGPS TEGAEGPEEK KKVKMRRKRR LPNKELSREL SKELNHEIQR
       970        980        990       1000       1010       1020
TENSLANENQ QPIKSEPESE GEEPKRPPGI CERPHRFSKG LNGTPRELRH QLGPSLRSPP
      1030       1040       1050       1060       1070       1080
RVISRPPPSV SPPKCIQMER HVIRPPPISP PPDSLPLDDG AAHVMHREVW MAVFSYLSHQ
      1090       1100       1110       1120       1130       1140
DLCVCMRVCR TWNRWCCDKR LWTRIDLNHC KSITPLMLSG IIRRQPVSLD LSWTNISKKQ
      1150       1160       1170       1180       1190       1200
LSWLINRLPG LRDLVLSGCS WIAVSALCSS SCPLLRTLDV QWVEGLKDAQ MRDLLSPPTD
      1210       1220       1230       1240       1250       1260
NRPGQMDNRS KLRNIVELRL AGLDITDASL RLIIRHMPLL SKLHLSYCNH VTDQSINLLT
      1270       1280       1290       1300       1310       1320
AVGTTTRDSL TEINLSDCNK VTDQCLSFFK RCGNICHIDL RYCKQVTKEG CEQFIAEMSV
      1330
SVQFGQVEEK LLQKLS         10         20         30         40         50         60
MAGPQMGGSA EDHPPRKRHA AEKQKKKTVI YTKCFEFESA TQRPIDRQRY DENEDLSDVE
        70         80         90        100        110        120
EIVSVRGFSL EEKLRSQLYQ GDFVHAMEGK DFNYEYVQRE ALRVPLIFRE KDGLGIKMPD
       130        140        150        160        170        180
PDFTVRDVKL LVGSRRLVDV MDVNTQKGTE MSMSQFVRYY ETPEAQRDKL YNVISLEFSH
       190        200        210        220        230        240
TKLEHLVKRP TVVDLVDWVD NMWPQHLKEK QTEATNAIAE MKYPKVKKYC LMSVKGCFTD
       250        260        270        280        290        300
FHIDFGGTSV WYHVFRGGKI FWLIPPTLHN LALYEEWVLS GKQSDIFLGD RVERCQRIEL
       310        320        330        340        350        360
KQGYTFFIPS GWIHAVYTPV DSLVFGGNIL HSFNVPMQLR IYEIEDRTRV QPKFRYPFYY
       370        380        390        400        410        420
EMCWYVLERY VYCVTQRSHL TQEYQRESML IDAPRKPSID GFSSDSWLEM EEEACDQQPQ
       430        440        450        460        470        480
EEEEKDEEGE GRDRAPKPPT DGSTSPTSTP SEDQEALGKK PKAPALRFLK RTLSNESEES
       490        500        510        520        530        540
VKSTTLAVDY PKTPTGSPAT EVSAKWTHLT EFELKGLKAL VEKLESLPEN KKCVPEGIED
       550        560        570        580        590        600
PQALLEGVKN VLKEHADDDP SLAITGVPVV TWPKKTPKNR AVGRPKGKLG PASAVKLAAN
       610        620        630        640        650        660
RTTAGARRRR TRCRKCEACL RTECGECHFC KDMKKFGGPG RMKQSCIMRQ CIAPVLPHTA
       670        680        690        700        710        720
VCLVCGEAGK EDTVEEEEGK FNLMLMECSI CNEIIHPGCL KIKESEGVVN DELPNCWECP
       730        740        750        760        770        780
KCNHAGKTGK QKRGPGFKYA SNLPGSLLKE QKMNRDNKEG QEPAKRRSEC EEAPRRRSDE
       790        800        810        820        830        840
HSKKVPPDGL LRRKSDDVHL RKKRKYEKPQ ELSGRKRASS LQTSPGSSSH LSPRPPLGSS
       850        860        870        880        890        900
LSPWWRSSLT YFQQQLKPGK EDKLFRKKRR SWKNAEDRMA LANKPLRRFK QEPEDELPEA
       910        920        930        940        950        960
PPKTRESDHS RSSSPTAGPS TEGAEGPEEK KKVKMRRKRR LPNKELSREL SKELNHEIQR
       970        980        990       1000       1010       1020
TENSLANENQ QPIKSEPESE GEEPKRPPGI CERPHRFSKG LNGTPRELRH QLGPSLRSPP
      1030       1040       1050       1060       1070       1080
RVISRPPPSV SPPKCIQMER HVIRPPPISP PPDSLPLDDG AAHVMHREVW MAVFSYLSHQ
      1090       1100       1110       1120       1130       1140
DLCVCMRVCR TWNRWCCDKR LWTRIDLNHC KSITPLMLSG IIRRQPVSLD LSWTNISKKQ
      1150       1160       1170       1180       1190       1200
LSWLINRLPG LRDLVLSGCS WIAVSALCSS SCPLLRTLDV QWVEGLKDAQ MRDLLSPPTD
      1210       1220       1230       1240       1250       1260
NRPGQMDNRS KLRNIVELRL AGLDITDASL RLIIRHMPLL SKLHLSYCNH VTDQSINLLT
      1270       1280       1290       1300       1310       1320
AVGTTTRDSL TEINLSDCNK VTDQCLSFFK RCGNICHIDL RYCKQVTKEG CEQFIAEMSV
      1330
SVQFGQVEEK LLQKLS         10         20         30         40         50         60
MAGPQMGGSA EDHPPRKRHA AEKQKKKTVI YTKCFEFESA TQRPIDRQRY DENEDLSDVE
        70         80         90        100        110        120
EIVSVRGFSL EEKLRSQLYQ GDFVHAMEGK DFNYEYVQRE ALRVPLIFRE KDGLGIKMPD
       130        140        150        160        170        180
PDFTVRDVKL LVGSRRLVDV MDVNTQKGTE MSMSQFVRYY ETPEAQRDKL YNVISLEFSH
       190        200        210        220        230        240
TKLEHLVKRP TVVDLVDWVD NMWPQHLKEK QTEATNAIAE MKYPKVKKYC LMSVKGCFTD
       250        260        270        280        290        300
FHIDFGGTSV WYHVFRGGKI FWLIPPTLHN LALYEEWVLS GKQSDIFLGD RVERCQRIEL
       310        320        330        340        350        360
KQGYTFFIPS GWIHAVYTPV DSLVFGGNIL HSFNVPMQLR IYEIEDRTRV QPKFRYPFYY
       370        380        390        400        410        420
EMCWYVLERY VYCVTQRSHL TQEYQRESML IDAPRKPSID GFSSDSWLEM EEEACDQQPQ
       430        440        450        460        470        480
EEEEKDEEGE GRDRAPKPPT DGSTSPTSTP SEDQEALGKK PKAPALRFLK RTLSNESEES
       490        500        510        520        530        540
VKSTTLAVDY PKTPTGSPAT EVSAKWTHLT EFELKGLKAL VEKLESLPEN KKCVPEGIED
       550        560        570        580        590        600
PQALLEGVKN VLKEHADDDP SLAITGVPVV TWPKKTPKNR AVGRPKGKLG PASAVKLAAN
       610        620        630        640        650        660
RTTAGARRRR TRCRKCEACL RTECGECHFC KDMKKFGGPG RMKQSCIMRQ CIAPVLPHTA
       670        680        690        700        710        720
VCLVCGEAGK EDTVEEEEGK FNLMLMECSI CNEIIHPGCL KIKESEGVVN DELPNCWECP
       730        740        750        760        770        780
KCNHAGKTGK QKRGPGFKYA SNLPGSLLKE QKMNRDNKEG QEPAKRRSEC EEAPRRRSDE
       790        800        810        820        830        840
HSKKVPPDGL LRRKSDDVHL RKKRKYEKPQ ELSGRKRASS LQTSPGSSSH LSPRPPLGSS
       850        860        870        880        890        900
LSPWWRSSLT YFQQQLKPGK EDKLFRKKRR SWKNAEDRMA LANKPLRRFK QEPEDELPEA
       910        920        930        940        950        960
PPKTRESDHS RSSSPTAGPS TEGAEGPEEK KKVKMRRKRR LPNKELSREL SKELNHEIQR
       970        980        990       1000       1010       1020
TENSLANENQ QPIKSEPESE GEEPKRPPGI CERPHRFSKG LNGTPRELRH QLGPSLRSPP
      1030       1040       1050       1060       1070       1080
RVISRPPPSV SPPKCIQMER HVIRPPPISP PPDSLPLDDG AAHVMHREVW MAVFSYLSHQ
      1090       1100       1110       1120       1130       1140
DLCVCMRVCR TWNRWCCDKR LWTRIDLNHC KSITPLMLSG IIRRQPVSLD LSWTNISKKQ
      1150       1160       1170       1180       1190       1200
LSWLINRLPG LRDLVLSGCS WIAVSALCSS SCPLLRTLDV QWVEGLKDAQ MRDLLSPPTD
      1210       1220       1230       1240       1250       1260
NRPGQMDNRS KLRNIVELRL AGLDITDASL RLIIRHMPLL SKLHLSYCNH VTDQSINLLT
      1270       1280       1290       1300       1310       1320
AVGTTTRDSL TEINLSDCNK VTDQCLSFFK RCGNICHIDL RYCKQVTKEG CEQFIAEMSV
      1330
SVQFGQVEEK LLQKLS         10         20         30         40         50         60
MAGPQMGGSA EDHPPRKRHA AEKQKKKTVI YTKCFEFESA TQRPIDRQRY DENEDLSDVE
        70         80         90        100        110        120
EIVSVRGFSL EEKLRSQLYQ GDFVHAMEGK DFNYEYVQRE ALRVPLIFRE KDGLGIKMPD
       130        140        150        160        170        180
PDFTVRDVKL LVGSRRLVDV MDVNTQKGTE MSMSQFVRYY ETPEAQRDKL YNVISLEFSH
       190        200        210        220        230        240
TKLEHLVKRP TVVDLVDWVD NMWPQHLKEK QTEATNAIAE MKYPKVKKYC LMSVKGCFTD
       250        260        270        280        290        300
FHIDFGGTSV WYHVFRGGKI FWLIPPTLHN LALYEEWVLS GKQSDIFLGD RVERCQRIEL
       310        320        330        340        350        360
KQGYTFFIPS GWIHAVYTPV DSLVFGGNIL HSFNVPMQLR IYEIEDRTRV QPKFRYPFYY
       370        380        390        400        410        420
EMCWYVLERY VYCVTQRSHL TQEYQRESML IDAPRKPSID GFSSDSWLEM EEEACDQQPQ
       430        440        450        460        470        480
EEEEKDEEGE GRDRAPKPPT DGSTSPTSTP SEDQEALGKK PKAPALRFLK RTLSNESEES
       490        500        510        520        530        540
VKSTTLAVDY PKTPTGSPAT EVSAKWTHLT EFELKGLKAL VEKLESLPEN KKCVPEGIED
       550        560        570        580        590        600
PQALLEGVKN VLKEHADDDP SLAITGVPVV TWPKKTPKNR AVGRPKGKLG PASAVKLAAN
       610        620        630        640        650        660
RTTAGARRRR TRCRKCEACL RTECGECHFC KDMKKFGGPG RMKQSCIMRQ CIAPVLPHTA
       670        680        690        700        710        720
VCLVCGEAGK EDTVEEEEGK FNLMLMECSI CNEIIHPGCL KIKESEGVVN DELPNCWECP
       730        740        750        760        770        780
KCNHAGKTGK QKRGPGFKYA SNLPGSLLKE QKMNRDNKEG QEPAKRRSEC EEAPRRRSDE
       790        800        810        820        830        840
HSKKVPPDGL LRRKSDDVHL RKKRKYEKPQ ELSGRKRASS LQTSPGSSSH LSPRPPLGSS
       850        860        870        880        890        900
LSPWWRSSLT YFQQQLKPGK EDKLFRKKRR SWKNAEDRMA LANKPLRRFK QEPEDELPEA
       910        920        930        940        950        960
PPKTRESDHS RSSSPTAGPS TEGAEGPEEK KKVKMRRKRR LPNKELSREL SKELNHEIQR
       970        980        990       1000       1010       1020
TENSLANENQ QPIKSEPESE GEEPKRPPGI CERPHRFSKG LNGTPRELRH QLGPSLRSPP
      1030       1040       1050       1060       1070       1080
RVISRPPPSV SPPKCIQMER HVIRPPPISP PPDSLPLDDG AAHVMHREVW MAVFSYLSHQ
      1090       1100       1110       1120       1130       1140
DLCVCMRVCR TWNRWCCDKR LWTRIDLNHC KSITPLMLSG IIRRQPVSLD LSWTNISKKQ
      1150       1160       1170       1180       1190       1200
LSWLINRLPG LRDLVLSGCS WIAVSALCSS SCPLLRTLDV QWVEGLKDAQ MRDLLSPPTD
      1210       1220       1230       1240       1250       1260
NRPGQMDNRS KLRNIVELRL AGLDITDASL RLIIRHMPLL SKLHLSYCNH VTDQSINLLT
      1270       1280       1290       1300       1310       1320
AVGTTTRDSL TEINLSDCNK VTDQCLSFFK RCGNICHIDL RYCKQVTKEG CEQFIAEMSV
      1330
SVQFGQVEEK LLQKLS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 7 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q8NHM5-1-unknown	MAGPQM...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8NHM5-1-unknown	MAGPQM...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt78864
Q8NHM5-1-unknown	MAGPQM...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt78865
Q8NHM5-118-unknown	MPDPDF...	118	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000440373
Q8NHM5-118-unknown	MPDPDF...	118	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000445196
Q8NHM5-118-unknown	MPDPDF...	118	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475517
Q8NHM5-118-unknown	MPDPDF...	118	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475558
Q8NHM5-118-unknown	MPDPDF...	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197209
Q8NHM5-118-unknown	MPDPDF...	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197210
Q8NHM5-118-unknown	MPDPDF...	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197211
Q8NHM5-232-unknown	MSVKGC...	232	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000445102
Q8NHM5-232-unknown	MSVKGC...	232	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437497
Q8NHM5-232-unknown	MSVKGC...	232	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000440942
Q8NHM5-232-unknown	MSVKGC...	232	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442293
Q8NHM5-232-unknown	MSVKGC...	232	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475299
Q8NHM5-232-unknown	MSVKGC...	232	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000476133
Q8NHM5-232-unknown	MSVKGC...	232	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475893
Q8NHM5-232-unknown	MSVKGC...	232	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475432
Q8NHM5-232-unknown	MSVKGC...	232	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198331
Q8NHM5-232-unknown	MSVKGC...	232	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198332
Q8NHM5-232-unknown	MSVKGC...	232	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198333
Q8NHM5-633-unknown	MKKFGG...	633	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437821
Q8NHM5-633-unknown	MKKFGG...	633	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000476072
Q8NHM5-633-unknown	MKKFGG...	633	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt200072
Q8NHM5-633-unknown	MKKFGG...	633	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt200073
Q8NHM5-633-unknown	MKKFGG...	633	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt200074

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ERCQRI	297	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000440373
...ERCQRI	297	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475558
...VFGGNI	328	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442293
...VFGGNI	328	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475432
...TQEYQR	385	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437497
...TQEYQR	385	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000476133
...SIDGFS	402	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000445102
...SIDGFS	402	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475299
...PQEEEE	423	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000444846
...PQEEEE	423	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475513
...ALLEGV	547	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000398279
...ALLEGV	547	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475848
...LQKLS	1336	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LQKLS	1336	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74483

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)