TopFIND 4.0

Q8NHP7: piRNA biogenesis protein EXD1 {ECO:0000305}

General Information

Protein names
- piRNA biogenesis protein EXD1 {ECO:0000305}
- Exonuclease 3'-5' domain-containing protein 1 {ECO:0000312|HGNC:HGNC:28507}
- Exonuclease 3'-5' domain-like-containing protein 1 {ECO:0000312|HGNC:HGNC:28507}
- Inactive exonuclease EXD1 {ECO:0000305}
Gene names EXD1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q8NHP7

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MEDSEFLAYV ELLDEVEQGS VRAKASSVSL HAERTWMEKM KVEDLNVCEP ASPAPEAPAT 
        70         80         90        100        110        120 
SLLNDLKYSP SEEEEVTYTV INQFQQKFGA AILHIKKQNV LSVAAEGANV CRHGKLCWLQ 
       130        140        150        160        170        180 
VATNCRVYLF DIFLLGSRAF HNGLQMILED KRILKVIHDC RWLSDCLSHQ YGILLNNVFD 
       190        200        210        220        230        240 
TQVADVLQFS METGGYLPNC ITTLQESLIK HLQVAPKYLS FLEKRQKLIQ ENPEVWFIRP 
       250        260        270        280        290        300 
VSPSLLKILA LEATYLLPLR LALLDEMMSD LTTLVDGYLN TYREGSADRL GGTEPTCMEL 
       310        320        330        340        350        360 
PEELLQLKDF QKQRREKAAR EYRVNAQGLL IRTVLQPKKL VTETAGKEEK VKGFLFGKNF 
       370        380        390        400        410        420 
RIDKAPSFTS QDFHGDVNLL KEESLNKQAT NPQHLPPTEE GETSEDSSNK LICTKSKGSE 
       430        440        450        460        470        480 
DQRITQKEHF MTPKHEFQAS LSLKEETEQL LMVENKEDLK CTKQAVSMSS FPQETRVSPS 
       490        500        510    
DTFYPIRKTV VSTLPPCPAL EKIDSWISPF LNLP

Isoforms

- Isoform 2 of Exonuclease 3'-5' domain-containing protein 1 - Isoform 3 of Exonuclease 3'-5' domain-containing protein 1 - Isoform 2 of piRNA biogenesis protein EXD1 - Isoform 3 of piRNA biogenesis protein EXD1

Sequence View

        10         20         30         40         50         60 
MEDSEFLAYV ELLDEVEQGS VRAKASSVSL HAERTWMEKM KVEDLNVCEP ASPAPEAPAT 
        70         80         90        100        110        120 
SLLNDLKYSP SEEEEVTYTV INQFQQKFGA AILHIKKQNV LSVAAEGANV CRHGKLCWLQ 
       130        140        150        160        170        180 
VATNCRVYLF DIFLLGSRAF HNGLQMILED KRILKVIHDC RWLSDCLSHQ YGILLNNVFD 
       190        200        210        220        230        240 
TQVADVLQFS METGGYLPNC ITTLQESLIK HLQVAPKYLS FLEKRQKLIQ ENPEVWFIRP 
       250        260        270        280        290        300 
VSPSLLKILA LEATYLLPLR LALLDEMMSD LTTLVDGYLN TYREGSADRL GGTEPTCMEL 
       310        320        330        340        350        360 
PEELLQLKDF QKQRREKAAR EYRVNAQGLL IRTVLQPKKL VTETAGKEEK VKGFLFGKNF 
       370        380        390        400        410        420 
RIDKAPSFTS QDFHGDVNLL KEESLNKQAT NPQHLPPTEE GETSEDSSNK LICTKSKGSE 
       430        440        450        460        470        480 
DQRITQKEHF MTPKHEFQAS LSLKEETEQL LMVENKEDLK CTKQAVSMSS FPQETRVSPS 
       490        500        510    
DTFYPIRKTV VSTLPPCPAL EKIDSWISPF LNLP         10         20         30         40         50         60 
MEDSEFLAYV ELLDEVEQGS VRAKASSVSL HAERTWMEKM KVEDLNVCEP ASPAPEAPAT 
        70         80         90        100        110        120 
SLLNDLKYSP SEEEEVTYTV INQFQQKFGA AILHIKKQNV LSVAAEGANV CRHGKLCWLQ 
       130        140        150        160        170        180 
VATNCRVYLF DIFLLGSRAF HNGLQMILED KRILKVIHDC RWLSDCLSHQ YGILLNNVFD 
       190        200        210        220        230        240 
TQVADVLQFS METGGYLPNC ITTLQESLIK HLQVAPKYLS FLEKRQKLIQ ENPEVWFIRP 
       250        260        270        280        290        300 
VSPSLLKILA LEATYLLPLR LALLDEMMSD LTTLVDGYLN TYREGSADRL GGTEPTCMEL 
       310        320        330        340        350        360 
PEELLQLKDF QKQRREKAAR EYRVNAQGLL IRTVLQPKKL VTETAGKEEK VKGFLFGKNF 
       370        380        390        400        410        420 
RIDKAPSFTS QDFHGDVNLL KEESLNKQAT NPQHLPPTEE GETSEDSSNK LICTKSKGSE 
       430        440        450        460        470        480 
DQRITQKEHF MTPKHEFQAS LSLKEETEQL LMVENKEDLK CTKQAVSMSS FPQETRVSPS 
       490        500        510    
DTFYPIRKTV VSTLPPCPAL EKIDSWISPF LNLP         10         20         30         40         50         60 
MEDSEFLAYV ELLDEVEQGS VRAKASSVSL HAERTWMEKM KVEDLNVCEP ASPAPEAPAT 
        70         80         90        100        110        120 
SLLNDLKYSP SEEEEVTYTV INQFQQKFGA AILHIKKQNV LSVAAEGANV CRHGKLCWLQ 
       130        140        150        160        170        180 
VATNCRVYLF DIFLLGSRAF HNGLQMILED KRILKVIHDC RWLSDCLSHQ YGILLNNVFD 
       190        200        210        220        230        240 
TQVADVLQFS METGGYLPNC ITTLQESLIK HLQVAPKYLS FLEKRQKLIQ ENPEVWFIRP 
       250        260        270        280        290        300 
VSPSLLKILA LEATYLLPLR LALLDEMMSD LTTLVDGYLN TYREGSADRL GGTEPTCMEL 
       310        320        330        340        350        360 
PEELLQLKDF QKQRREKAAR EYRVNAQGLL IRTVLQPKKL VTETAGKEEK VKGFLFGKNF 
       370        380        390        400        410        420 
RIDKAPSFTS QDFHGDVNLL KEESLNKQAT NPQHLPPTEE GETSEDSSNK LICTKSKGSE 
       430        440        450        460        470        480 
DQRITQKEHF MTPKHEFQAS LSLKEETEQL LMVENKEDLK CTKQAVSMSS FPQETRVSPS 
       490        500        510    
DTFYPIRKTV VSTLPPCPAL EKIDSWISPF LNLP         10         20         30         40         50         60 
MEDSEFLAYV ELLDEVEQGS VRAKASSVSL HAERTWMEKM KVEDLNVCEP ASPAPEAPAT 
        70         80         90        100        110        120 
SLLNDLKYSP SEEEEVTYTV INQFQQKFGA AILHIKKQNV LSVAAEGANV CRHGKLCWLQ 
       130        140        150        160        170        180 
VATNCRVYLF DIFLLGSRAF HNGLQMILED KRILKVIHDC RWLSDCLSHQ YGILLNNVFD 
       190        200        210        220        230        240 
TQVADVLQFS METGGYLPNC ITTLQESLIK HLQVAPKYLS FLEKRQKLIQ ENPEVWFIRP 
       250        260        270        280        290        300 
VSPSLLKILA LEATYLLPLR LALLDEMMSD LTTLVDGYLN TYREGSADRL GGTEPTCMEL 
       310        320        330        340        350        360 
PEELLQLKDF QKQRREKAAR EYRVNAQGLL IRTVLQPKKL VTETAGKEEK VKGFLFGKNF 
       370        380        390        400        410        420 
RIDKAPSFTS QDFHGDVNLL KEESLNKQAT NPQHLPPTEE GETSEDSSNK LICTKSKGSE 
       430        440        450        460        470        480 
DQRITQKEHF MTPKHEFQAS LSLKEETEQL LMVENKEDLK CTKQAVSMSS FPQETRVSPS 
       490        500        510    
DTFYPIRKTV VSTLPPCPAL EKIDSWISPF LNLP



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Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8NHP7-1-unknown MEDSEF... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)