Q8NI08: Nuclear receptor coactivator 7

General Information

Protein names	- Nuclear receptor coactivator 7 - 140 kDa estrogen receptor-associated protein - Estrogen nuclear receptor coactivator 1
Gene names	NCOA7
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8NI08

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Nuclear receptor coactivator 7 - Isoform 3 of Nuclear receptor coactivator 7 - Isoform 4 of Nuclear receptor coactivator 7 - Isoform 5 of Nuclear receptor coactivator 7 - Isoform 6 of Nuclear receptor coactivator 7 - Isoform 7 of Nuclear receptor coactivator 7

Sequence View

        10         20         30         40         50         60
MDTKEEKKER KQSYFARLKK KKQAKQNAET ASAVATRTHT GKEDNNTVVL EPDKCNIAVE
        70         80         90        100        110        120
EEYMTDEKKK RKSNQLKEIR RTELKRYYSI DDNQNKTHDK KEKKMVVQKP HGTMEYTAGN
       130        140        150        160        170        180
QDTLNSIALK FNITPNKLVE LNKLFTHTIV PGQVLFVPDA NSPSSTLRLS SSSPGATVSP
       190        200        210        220        230        240
SSSDAEYDKL PDADLARKAL KPIERVLSST SEEDEPGVVK FLKMNCRYFT DGKGVVGGVM
       250        260        270        280        290        300
IVTPNNIMFD PHKSDPLVIE NGCEEYGLIC PMEEVVSIAL YNDISHMKIK DALPSDLPQD
       310        320        330        340        350        360
LCPLYRPGEW EDLASEKDIN PFSKFKSINK EKRQQNGEKI MTSDSRPIVP LEKSTGHTPT
       370        380        390        400        410        420
KPSGSSVSEK LKKLDSSRET SHGSPTVTKL SKEPSDTSSA FESTAKENFL GEDDDFVDLE
       430        440        450        460        470        480
ELSSQTGGGM HKKDTLKECL SLDPEERKKA ESQINNSAVE MQVQSALAFL GTENDVELKG
       490        500        510        520        530        540
ALDLETCEKQ DIMPEVDKQS GSPESRVENT LNIHEDLDKV KLIEYYLTKN KEGPQVSENL
       550        560        570        580        590        600
QKTELSDGKS IEPGGIDITL SSSLSQAGDP ITEGNKEPDK TWVKKGEPLP VKLNSSTEAN
       610        620        630        640        650        660
VIKEALDSSL ESTLDNSCQG AQMDNKSEVQ LWLLKRIQVP IEDILPSKEE KSKTPPMFLC
       670        680        690        700        710        720
IKVGKPMRKS FATHTAAMVQ QYGKRRKQPE YWFAVPRERV DHLYTFFVQW SPDVYGKDAK
       730        740        750        760        770        780
EQGFVVVEKE ELNMIDNFFS EPTTKSWEII TVEEAKRRKS TCSYYEDEDE EVLPVLRPHS
       790        800        810        820        830        840
ALLENMHIEQ LARRLPARVQ GYPWRLAYST LEHGTSLKTL YRKSASLDSP VLLVIKDMDN
       850        860        870        880        890        900
QIFGAYATHP FKFSDHYYGT GETFLYTFSP HFKVFKWSGE NSYFINGDIS SLELGGGGGR
       910        920        930        940
FGLWLDADLY HGRSNSCSTF NNDILSKKED FIVQDLEVWA FD         10         20         30         40         50         60
MDTKEEKKER KQSYFARLKK KKQAKQNAET ASAVATRTHT GKEDNNTVVL EPDKCNIAVE
        70         80         90        100        110        120
EEYMTDEKKK RKSNQLKEIR RTELKRYYSI DDNQNKTHDK KEKKMVVQKP HGTMEYTAGN
       130        140        150        160        170        180
QDTLNSIALK FNITPNKLVE LNKLFTHTIV PGQVLFVPDA NSPSSTLRLS SSSPGATVSP
       190        200        210        220        230        240
SSSDAEYDKL PDADLARKAL KPIERVLSST SEEDEPGVVK FLKMNCRYFT DGKGVVGGVM
       250        260        270        280        290        300
IVTPNNIMFD PHKSDPLVIE NGCEEYGLIC PMEEVVSIAL YNDISHMKIK DALPSDLPQD
       310        320        330        340        350        360
LCPLYRPGEW EDLASEKDIN PFSKFKSINK EKRQQNGEKI MTSDSRPIVP LEKSTGHTPT
       370        380        390        400        410        420
KPSGSSVSEK LKKLDSSRET SHGSPTVTKL SKEPSDTSSA FESTAKENFL GEDDDFVDLE
       430        440        450        460        470        480
ELSSQTGGGM HKKDTLKECL SLDPEERKKA ESQINNSAVE MQVQSALAFL GTENDVELKG
       490        500        510        520        530        540
ALDLETCEKQ DIMPEVDKQS GSPESRVENT LNIHEDLDKV KLIEYYLTKN KEGPQVSENL
       550        560        570        580        590        600
QKTELSDGKS IEPGGIDITL SSSLSQAGDP ITEGNKEPDK TWVKKGEPLP VKLNSSTEAN
       610        620        630        640        650        660
VIKEALDSSL ESTLDNSCQG AQMDNKSEVQ LWLLKRIQVP IEDILPSKEE KSKTPPMFLC
       670        680        690        700        710        720
IKVGKPMRKS FATHTAAMVQ QYGKRRKQPE YWFAVPRERV DHLYTFFVQW SPDVYGKDAK
       730        740        750        760        770        780
EQGFVVVEKE ELNMIDNFFS EPTTKSWEII TVEEAKRRKS TCSYYEDEDE EVLPVLRPHS
       790        800        810        820        830        840
ALLENMHIEQ LARRLPARVQ GYPWRLAYST LEHGTSLKTL YRKSASLDSP VLLVIKDMDN
       850        860        870        880        890        900
QIFGAYATHP FKFSDHYYGT GETFLYTFSP HFKVFKWSGE NSYFINGDIS SLELGGGGGR
       910        920        930        940
FGLWLDADLY HGRSNSCSTF NNDILSKKED FIVQDLEVWA FD         10         20         30         40         50         60
MDTKEEKKER KQSYFARLKK KKQAKQNAET ASAVATRTHT GKEDNNTVVL EPDKCNIAVE
        70         80         90        100        110        120
EEYMTDEKKK RKSNQLKEIR RTELKRYYSI DDNQNKTHDK KEKKMVVQKP HGTMEYTAGN
       130        140        150        160        170        180
QDTLNSIALK FNITPNKLVE LNKLFTHTIV PGQVLFVPDA NSPSSTLRLS SSSPGATVSP
       190        200        210        220        230        240
SSSDAEYDKL PDADLARKAL KPIERVLSST SEEDEPGVVK FLKMNCRYFT DGKGVVGGVM
       250        260        270        280        290        300
IVTPNNIMFD PHKSDPLVIE NGCEEYGLIC PMEEVVSIAL YNDISHMKIK DALPSDLPQD
       310        320        330        340        350        360
LCPLYRPGEW EDLASEKDIN PFSKFKSINK EKRQQNGEKI MTSDSRPIVP LEKSTGHTPT
       370        380        390        400        410        420
KPSGSSVSEK LKKLDSSRET SHGSPTVTKL SKEPSDTSSA FESTAKENFL GEDDDFVDLE
       430        440        450        460        470        480
ELSSQTGGGM HKKDTLKECL SLDPEERKKA ESQINNSAVE MQVQSALAFL GTENDVELKG
       490        500        510        520        530        540
ALDLETCEKQ DIMPEVDKQS GSPESRVENT LNIHEDLDKV KLIEYYLTKN KEGPQVSENL
       550        560        570        580        590        600
QKTELSDGKS IEPGGIDITL SSSLSQAGDP ITEGNKEPDK TWVKKGEPLP VKLNSSTEAN
       610        620        630        640        650        660
VIKEALDSSL ESTLDNSCQG AQMDNKSEVQ LWLLKRIQVP IEDILPSKEE KSKTPPMFLC
       670        680        690        700        710        720
IKVGKPMRKS FATHTAAMVQ QYGKRRKQPE YWFAVPRERV DHLYTFFVQW SPDVYGKDAK
       730        740        750        760        770        780
EQGFVVVEKE ELNMIDNFFS EPTTKSWEII TVEEAKRRKS TCSYYEDEDE EVLPVLRPHS
       790        800        810        820        830        840
ALLENMHIEQ LARRLPARVQ GYPWRLAYST LEHGTSLKTL YRKSASLDSP VLLVIKDMDN
       850        860        870        880        890        900
QIFGAYATHP FKFSDHYYGT GETFLYTFSP HFKVFKWSGE NSYFINGDIS SLELGGGGGR
       910        920        930        940
FGLWLDADLY HGRSNSCSTF NNDILSKKED FIVQDLEVWA FD         10         20         30         40         50         60
MDTKEEKKER KQSYFARLKK KKQAKQNAET ASAVATRTHT GKEDNNTVVL EPDKCNIAVE
        70         80         90        100        110        120
EEYMTDEKKK RKSNQLKEIR RTELKRYYSI DDNQNKTHDK KEKKMVVQKP HGTMEYTAGN
       130        140        150        160        170        180
QDTLNSIALK FNITPNKLVE LNKLFTHTIV PGQVLFVPDA NSPSSTLRLS SSSPGATVSP
       190        200        210        220        230        240
SSSDAEYDKL PDADLARKAL KPIERVLSST SEEDEPGVVK FLKMNCRYFT DGKGVVGGVM
       250        260        270        280        290        300
IVTPNNIMFD PHKSDPLVIE NGCEEYGLIC PMEEVVSIAL YNDISHMKIK DALPSDLPQD
       310        320        330        340        350        360
LCPLYRPGEW EDLASEKDIN PFSKFKSINK EKRQQNGEKI MTSDSRPIVP LEKSTGHTPT
       370        380        390        400        410        420
KPSGSSVSEK LKKLDSSRET SHGSPTVTKL SKEPSDTSSA FESTAKENFL GEDDDFVDLE
       430        440        450        460        470        480
ELSSQTGGGM HKKDTLKECL SLDPEERKKA ESQINNSAVE MQVQSALAFL GTENDVELKG
       490        500        510        520        530        540
ALDLETCEKQ DIMPEVDKQS GSPESRVENT LNIHEDLDKV KLIEYYLTKN KEGPQVSENL
       550        560        570        580        590        600
QKTELSDGKS IEPGGIDITL SSSLSQAGDP ITEGNKEPDK TWVKKGEPLP VKLNSSTEAN
       610        620        630        640        650        660
VIKEALDSSL ESTLDNSCQG AQMDNKSEVQ LWLLKRIQVP IEDILPSKEE KSKTPPMFLC
       670        680        690        700        710        720
IKVGKPMRKS FATHTAAMVQ QYGKRRKQPE YWFAVPRERV DHLYTFFVQW SPDVYGKDAK
       730        740        750        760        770        780
EQGFVVVEKE ELNMIDNFFS EPTTKSWEII TVEEAKRRKS TCSYYEDEDE EVLPVLRPHS
       790        800        810        820        830        840
ALLENMHIEQ LARRLPARVQ GYPWRLAYST LEHGTSLKTL YRKSASLDSP VLLVIKDMDN
       850        860        870        880        890        900
QIFGAYATHP FKFSDHYYGT GETFLYTFSP HFKVFKWSGE NSYFINGDIS SLELGGGGGR
       910        920        930        940
FGLWLDADLY HGRSNSCSTF NNDILSKKED FIVQDLEVWA FD         10         20         30         40         50         60
MDTKEEKKER KQSYFARLKK KKQAKQNAET ASAVATRTHT GKEDNNTVVL EPDKCNIAVE
        70         80         90        100        110        120
EEYMTDEKKK RKSNQLKEIR RTELKRYYSI DDNQNKTHDK KEKKMVVQKP HGTMEYTAGN
       130        140        150        160        170        180
QDTLNSIALK FNITPNKLVE LNKLFTHTIV PGQVLFVPDA NSPSSTLRLS SSSPGATVSP
       190        200        210        220        230        240
SSSDAEYDKL PDADLARKAL KPIERVLSST SEEDEPGVVK FLKMNCRYFT DGKGVVGGVM
       250        260        270        280        290        300
IVTPNNIMFD PHKSDPLVIE NGCEEYGLIC PMEEVVSIAL YNDISHMKIK DALPSDLPQD
       310        320        330        340        350        360
LCPLYRPGEW EDLASEKDIN PFSKFKSINK EKRQQNGEKI MTSDSRPIVP LEKSTGHTPT
       370        380        390        400        410        420
KPSGSSVSEK LKKLDSSRET SHGSPTVTKL SKEPSDTSSA FESTAKENFL GEDDDFVDLE
       430        440        450        460        470        480
ELSSQTGGGM HKKDTLKECL SLDPEERKKA ESQINNSAVE MQVQSALAFL GTENDVELKG
       490        500        510        520        530        540
ALDLETCEKQ DIMPEVDKQS GSPESRVENT LNIHEDLDKV KLIEYYLTKN KEGPQVSENL
       550        560        570        580        590        600
QKTELSDGKS IEPGGIDITL SSSLSQAGDP ITEGNKEPDK TWVKKGEPLP VKLNSSTEAN
       610        620        630        640        650        660
VIKEALDSSL ESTLDNSCQG AQMDNKSEVQ LWLLKRIQVP IEDILPSKEE KSKTPPMFLC
       670        680        690        700        710        720
IKVGKPMRKS FATHTAAMVQ QYGKRRKQPE YWFAVPRERV DHLYTFFVQW SPDVYGKDAK
       730        740        750        760        770        780
EQGFVVVEKE ELNMIDNFFS EPTTKSWEII TVEEAKRRKS TCSYYEDEDE EVLPVLRPHS
       790        800        810        820        830        840
ALLENMHIEQ LARRLPARVQ GYPWRLAYST LEHGTSLKTL YRKSASLDSP VLLVIKDMDN
       850        860        870        880        890        900
QIFGAYATHP FKFSDHYYGT GETFLYTFSP HFKVFKWSGE NSYFINGDIS SLELGGGGGR
       910        920        930        940
FGLWLDADLY HGRSNSCSTF NNDILSKKED FIVQDLEVWA FD         10         20         30         40         50         60
MDTKEEKKER KQSYFARLKK KKQAKQNAET ASAVATRTHT GKEDNNTVVL EPDKCNIAVE
        70         80         90        100        110        120
EEYMTDEKKK RKSNQLKEIR RTELKRYYSI DDNQNKTHDK KEKKMVVQKP HGTMEYTAGN
       130        140        150        160        170        180
QDTLNSIALK FNITPNKLVE LNKLFTHTIV PGQVLFVPDA NSPSSTLRLS SSSPGATVSP
       190        200        210        220        230        240
SSSDAEYDKL PDADLARKAL KPIERVLSST SEEDEPGVVK FLKMNCRYFT DGKGVVGGVM
       250        260        270        280        290        300
IVTPNNIMFD PHKSDPLVIE NGCEEYGLIC PMEEVVSIAL YNDISHMKIK DALPSDLPQD
       310        320        330        340        350        360
LCPLYRPGEW EDLASEKDIN PFSKFKSINK EKRQQNGEKI MTSDSRPIVP LEKSTGHTPT
       370        380        390        400        410        420
KPSGSSVSEK LKKLDSSRET SHGSPTVTKL SKEPSDTSSA FESTAKENFL GEDDDFVDLE
       430        440        450        460        470        480
ELSSQTGGGM HKKDTLKECL SLDPEERKKA ESQINNSAVE MQVQSALAFL GTENDVELKG
       490        500        510        520        530        540
ALDLETCEKQ DIMPEVDKQS GSPESRVENT LNIHEDLDKV KLIEYYLTKN KEGPQVSENL
       550        560        570        580        590        600
QKTELSDGKS IEPGGIDITL SSSLSQAGDP ITEGNKEPDK TWVKKGEPLP VKLNSSTEAN
       610        620        630        640        650        660
VIKEALDSSL ESTLDNSCQG AQMDNKSEVQ LWLLKRIQVP IEDILPSKEE KSKTPPMFLC
       670        680        690        700        710        720
IKVGKPMRKS FATHTAAMVQ QYGKRRKQPE YWFAVPRERV DHLYTFFVQW SPDVYGKDAK
       730        740        750        760        770        780
EQGFVVVEKE ELNMIDNFFS EPTTKSWEII TVEEAKRRKS TCSYYEDEDE EVLPVLRPHS
       790        800        810        820        830        840
ALLENMHIEQ LARRLPARVQ GYPWRLAYST LEHGTSLKTL YRKSASLDSP VLLVIKDMDN
       850        860        870        880        890        900
QIFGAYATHP FKFSDHYYGT GETFLYTFSP HFKVFKWSGE NSYFINGDIS SLELGGGGGR
       910        920        930        940
FGLWLDADLY HGRSNSCSTF NNDILSKKED FIVQDLEVWA FD

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8NI08-1-Acetylation	MDTKEE...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8NI08-1-Acetylation	MDTKEE...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8NI08-1-Acetylation	MDTKEE...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8NI08-1-Acetylation	MDTKEE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98757
Q8NI08-1-Acetylation	MDTKEE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98758
Q8NI08-1-Acetylation	MDTKEE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98759
Q8NI08-1-Acetylation	MDTKEE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98760
Q8NI08-1-unknown	MDTKEE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82416
Q8NI08-1-unknown	MDTKEE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82417
Q8NI08-1-unknown	MDTKEE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82418
Q8NI08-1-unknown	MDTKEE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82420
Q8NI08-105-unknown	MVVQKP...	105		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82421
Q8NI08-105-unknown	MVVQKP...	105		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt109488
Q8NI08-105-unknown	MVVQKP...	105		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt109489
Q8NI08-105-unknown	MVVQKP...	105		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt109490

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DALPSD	295	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78035
...DALPSD	295	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92266
...DALPSD	295	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92267
...VWAFD	942	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VWAFD	942	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78037
...VWAFD	942	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78039
...VWAFD	942	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78034

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)