TopFIND 4.0

Q8R0N6: Hydroxyacid-oxoacid transhydrogenase, mitochondrial

General Information

Protein names
- Hydroxyacid-oxoacid transhydrogenase, mitochondrial
- HOT
- 1.1.99.24
- Alcohol dehydrogenase iron-containing protein 1
- ADHFe1
Gene names Adhfe1
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q8R0N6

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAAAARARVT HLLRHLQSTA CQCPTHSHTY SQAPGPSGKT ADYAFEMAVS NIRYGAGVTK 
        70         80         90        100        110        120 
EVGMDLQNMG AKNVCLMTDK NLSQLPPVQI VMDSLSKNGI SFQVYDDVRV EPTDGSFMDA 
       130        140        150        160        170        180 
IEFAKKGAFD AYVAVGGGST MDTCKAANLY ASSPHSEFLD YVNAPIGKGK PVTVPLKPLI 
       190        200        210        220        230        240 
AVPTTSGTGS ETTGVAIFDY EHLKVKTGIA SRAIKPTLGL VDPLHTLHMP CQVVANSGFD 
       250        260        270        280        290        300 
VLCHALESYT AIPYSMRSPC PSNPIQRPAY QGSNPISDIW AVHALQIVAK YLKRAVRNPD 
       310        320        330        340        350        360 
DLEARSKMHL ASAFAGIGFG NAGVHLCHGM SYPISGLVKT YKAKEYNVDH PLVPHGLSVV 
       370        380        390        400        410        420 
LTSPAVFTFT AQMFPERHLE TAGILGANIR TARIQDAGLV LADALRKFLF DLNVDDGLAA 
       430        440        450        460    
LGYSKDDIPS LVKGTLPQER VTKLAPRAQS EEDLSALFEA SMKLY

Isoforms

- Isoform 2 of Hydroxyacid-oxoacid transhydrogenase, mitochondrial

Sequence View

        10         20         30         40         50         60 
MAAAARARVT HLLRHLQSTA CQCPTHSHTY SQAPGPSGKT ADYAFEMAVS NIRYGAGVTK 
        70         80         90        100        110        120 
EVGMDLQNMG AKNVCLMTDK NLSQLPPVQI VMDSLSKNGI SFQVYDDVRV EPTDGSFMDA 
       130        140        150        160        170        180 
IEFAKKGAFD AYVAVGGGST MDTCKAANLY ASSPHSEFLD YVNAPIGKGK PVTVPLKPLI 
       190        200        210        220        230        240 
AVPTTSGTGS ETTGVAIFDY EHLKVKTGIA SRAIKPTLGL VDPLHTLHMP CQVVANSGFD 
       250        260        270        280        290        300 
VLCHALESYT AIPYSMRSPC PSNPIQRPAY QGSNPISDIW AVHALQIVAK YLKRAVRNPD 
       310        320        330        340        350        360 
DLEARSKMHL ASAFAGIGFG NAGVHLCHGM SYPISGLVKT YKAKEYNVDH PLVPHGLSVV 
       370        380        390        400        410        420 
LTSPAVFTFT AQMFPERHLE TAGILGANIR TARIQDAGLV LADALRKFLF DLNVDDGLAA 
       430        440        450        460    
LGYSKDDIPS LVKGTLPQER VTKLAPRAQS EEDLSALFEA SMKLY



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8R0N6-0-unknown YMAAAA... 0 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8R0N6-47-unknown MAVSNI... 47 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt77229

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...SMKLY 465 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...SMKLY 465 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt72847

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)