TopFIND 4.0

Q8R4H2: Rho guanine nucleotide exchange factor 12

General Information

Protein names
- Rho guanine nucleotide exchange factor 12
- Leukemia-associated RhoGEF
Gene names Arhgef12
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q8R4H2

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSGTQSTITD RFPLKKPIRH GSILNRESPT DKKQKVERSS SHDFDPTDSS SKKTKSSSEE 
        70         80         90        100        110        120 
SRSEIYGLVQ RCVIIQKDDN GFGLTVSGDN PVFVQSVKED GAAMRAGVQT GDRIIKVNGT 
       130        140        150        160        170        180 
LVTHSNHLEV VKLIRSGSYV ALTVQGRPPG SPQIPLADSE VEPSVTGHMS PIMTSPHSPG 
       190        200        210        220        230        240 
AAGNMERITS PVLVGEENNV VHNQKVEILR KMLQKEQERL QLLQEDYNRT ATQRLLKEIQ 
       250        260        270        280        290        300 
EAKKHIPQLQ EQLSKATGSA QDGAVIAPSR PLGDALTLSE AEADPGDGLC RTDWSSGDAS 
       310        320        330        340        350        360 
RPSSDSADSP KSSLRERSYL EEAPERSEGV QDAEPQSLVG SPSTRGAPHI IGAEDDDFGT 
       370        380        390        400        410        420 
EHEQINGQCS CFQSIELLKS RPAHLAVFLH HVVSQFDPAT LLCYLYSDLY KQTNSKETRR 
       430        440        450        460        470        480 
VFLEFHQFFL DRSAHLKVPV PEEISVDLEK RRPELIPEDL HRLYIQTMQE RVHPEVQRHL 
       490        500        510        520        530        540 
EDFRQKRSMG LTLAESELTK LDAERDKDRG TLEKERACAE QIVTKIEEVL MTAQAVEEER 
       550        560        570        580        590        600 
SSTMQYVILM YMKYLGVKVK EPRNLEHKRG RIGFLPKIKQ SMKKDREGEE KGKRRGFPSI 
       610        620        630        640        650        660 
LGPPRRPSRH DNSAIGRAME IQKSRHPKHL STPSSVSPEP QDPAKLRQSG VANEGTDTGY 
       670        680        690        700        710        720 
LPASSMSSAT SGTALSQEGG RENDTGTKQV GEASAPGDCL DSTPRVPTTV FDFPPPLLDQ 
       730        740        750        760        770        780 
VQEEECEVER VAEHGTPKPF RKFDSIAFGE SQSEDEQFEN DLETDPPNWQ QLVSREVLLG 
       790        800        810        820        830        840 
LKPSEIKRQE VINELFYTER AHVRTLKVLD QVFYQRVSRE GILSPSELRK IFSNLEDILQ 
       850        860        870        880        890        900 
LHVGLNEQMK AVRKRNETSV IDHIGEDLLI WFSGPGEEKL KHAAATFCSN QPFALEMIKS 
       910        920        930        940        950        960 
RQKKDSRFHT FVQDAESNPL CRRLQLKDII PTQMQRLTKY PLLLDNIAKY TEWPPEREKV 
       970        980        990       1000       1010       1020 
KKAADHCRQI LNYVNQAVRE AENKQRLEDY QRRLDTSNLK LSEYPNVDEL RNLDLTKRKM 
      1030       1040       1050       1060       1070       1080 
IHEGPLVWKV NRDKSIDLYT LLLEDILVLL QKQDDRLVLR CHSKILASTA DSKHTFSPVI 
      1090       1100       1110       1120       1130       1140 
KLSTVLVRQV ATDNKALFVI SMSDNGAQIY ELVAQTVSEK TVWQDLICRM AASVKEQSTK 
      1150       1160       1170       1180       1190       1200 
PIPLPQPPPC EGDNDEEEPA KLKVEHHDLS VAGLQSPDRV LGLESPLISS KPQSHSLNTP 
      1210       1220       1230       1240       1250       1260 
GKSAAEHLFV TATQFAKEQH ANGALKEGDG GYPVTIPGPH LPVSEERWAL DALRNLGLLK 
      1270       1280       1290       1300       1310       1320 
QLLVQQLGLT EKSTQEDWQS FSRYGPASEE VQADSGIRDL ENVKACHARE GQMSFKTGTG 
      1330       1340       1350       1360       1370       1380 
DIATCDSPRT STESCAAQDS VILASQDSQA SNVLVMDHMI LTPEMPPAEP EGGLDESGEH 
      1390       1400       1410       1420       1430       1440 
FFDAREAHSD DNPSEGDGAV KKEEKDVNLR ISGNCLILDG YDAVQESSTD EEVASSFPLQ 
      1450       1460       1470       1480       1490       1500 
PVTGIPAVDS SHQQQHSPQN VHPEGPVSPF TPEFLVQRHW RAMEDTCFEI QSPSCTDSQS 
      1510       1520       1530       1540    
QILEYIHKIE ADLEHLKKVE ESYALLCQRL AGSALPDKLS DKS

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LSDKS 1543 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)