TopFIND 4.0

Q8R5M4: Optineurin

General Information

Protein names
- Optineurin
- FIP-2-like protein
Gene names Optn
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID Q8R5M4

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSHQPLSCLT EKGDSSCETP GNGPSNMVHP NLDTFTPEEL LQQMKELLVE NHQLKEAMKL 
        70         80         90        100        110        120 
NNQAMKGRFE ELSAWTEKQK EERQLFEIQS KEAKERLKAL SHENERLKEE LGKLKEKSER 
       130        140        150        160        170        180 
PFEDITGRCG FPRTDLEQEV EQLKRQVEQE VEHLKIQVRR LQAEKADLLG IVSELQLKLN 
       190        200        210        220        230        240 
SGGSSEDSFV EIRMTEGEAE GAMKEMRNSA GPTRTDSISM GKCTEDARTC VEFEELTVSQ 
       250        260        270        280        290        300 
LLLCLREGNQ KVERLEIALR EAKERISDFE KKANGHSAIE TQTEGSTQKE EEDKDPESVG 
       310        320        330        340        350        360 
IEVETLNVQV ASLFKELQEA HTKLSEAELM KKRLQEKCQA LERKNSATPS ELNEKQELVY 
       370        380        390        400        410        420 
SNRKLELQVE SMRSEIKMEQ AKTEEEKSRL ATLQATHDKL LQEHNKALRT IEELTKQQAE 
       430        440        450        460        470        480 
KVDKVQLQEL SEKLELAEQA LASKQLQMDE MKQTIAKQEE DLETMAVLRA QMEVYCSDFH 
       490        500        510        520        530        540 
AERAAREKIH EEKEQLALQL AILLKENNDF EDGGSRQSLM EMQCRHGART SDSDQQAYLF 
       550        560        570        580    
QRGAEDMSWQ HGQQPRSIPI HSCPKCGEVL PDIDTLQIHV MDCII

Isoforms

- Isoform 2 of Optineurin

Sequence View

        10         20         30         40         50         60 
MSHQPLSCLT EKGDSSCETP GNGPSNMVHP NLDTFTPEEL LQQMKELLVE NHQLKEAMKL 
        70         80         90        100        110        120 
NNQAMKGRFE ELSAWTEKQK EERQLFEIQS KEAKERLKAL SHENERLKEE LGKLKEKSER 
       130        140        150        160        170        180 
PFEDITGRCG FPRTDLEQEV EQLKRQVEQE VEHLKIQVRR LQAEKADLLG IVSELQLKLN 
       190        200        210        220        230        240 
SGGSSEDSFV EIRMTEGEAE GAMKEMRNSA GPTRTDSISM GKCTEDARTC VEFEELTVSQ 
       250        260        270        280        290        300 
LLLCLREGNQ KVERLEIALR EAKERISDFE KKANGHSAIE TQTEGSTQKE EEDKDPESVG 
       310        320        330        340        350        360 
IEVETLNVQV ASLFKELQEA HTKLSEAELM KKRLQEKCQA LERKNSATPS ELNEKQELVY 
       370        380        390        400        410        420 
SNRKLELQVE SMRSEIKMEQ AKTEEEKSRL ATLQATHDKL LQEHNKALRT IEELTKQQAE 
       430        440        450        460        470        480 
KVDKVQLQEL SEKLELAEQA LASKQLQMDE MKQTIAKQEE DLETMAVLRA QMEVYCSDFH 
       490        500        510        520        530        540 
AERAAREKIH EEKEQLALQL AILLKENNDF EDGGSRQSLM EMQCRHGART SDSDQQAYLF 
       550        560        570        580    
QRGAEDMSWQ HGQQPRSIPI HSCPKCGEVL PDIDTLQIHV MDCII



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8R5M4-1-unknown MSHQPL... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8R5M4-1-unknown MSHQPL... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt193200

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...MDCII 585 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...MDCII 585 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt153146

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)