Q8TBB5: Kelch domain-containing protein 4

General Information

Protein names	- Kelch domain-containing protein 4
Gene names	KLHDC4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8TBB5

4 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Kelch domain-containing protein 4 - Isoform 3 of Kelch domain-containing protein 4

Sequence View

        10         20         30         40         50         60
MGKKGKKEKK GRGAEKTAAK MEKKVSKRSR KEEEDLEALI AHFQTLDAKR TQTVELPCPP
        70         80         90        100        110        120
PSPRLNASLS VHPEKDELIL FGGEYFNGQK TFLYNELYVY NTRKDTWTKV DIPSPPPRRC
       130        140        150        160        170        180
AHQAVVVPQG GGQLWVFGGE FASPNGEQFY HYKDLWVLHL ATKTWEQVKS TGGPSGRSGH
       190        200        210        220        230        240
RMVAWKRQLI LFGGFHESTR DYIYYNDVYA FNLDTFTWSK LSPSGTGPTP RSGCQMSVTP
       250        260        270        280        290        300
QGGIVVYGGY SKQRVKKDVD KGTRHSDMFL LKPEDGREDK WVWTRMNPSG VKPTPRSGFS
       310        320        330        340        350        360
VAMAPNHQTL FFGGVCDEEE EESLSGEFFN DLYFYDATRN RWFEGQLKGP KSEKKKRRRG
       370        380        390        400        410        420
RKEEPEGGSR PACGGAGTQG PVQLVKEVVA EDGTVVTIKQ VLTAPGSAGQ PRSEDEDSLE
       430        440        450        460        470        480
EAGSPAPGPC PRSNAMLAVK HGVLYVYGGM FEAGDRQVTL SDLHCLDLHR MEAWKALVEM
       490        500        510        520
DPETQEWLEE TDSEEDSEEV EGAEGGVDDE DSGEESGAED         10         20         30         40         50         60
MGKKGKKEKK GRGAEKTAAK MEKKVSKRSR KEEEDLEALI AHFQTLDAKR TQTVELPCPP
        70         80         90        100        110        120
PSPRLNASLS VHPEKDELIL FGGEYFNGQK TFLYNELYVY NTRKDTWTKV DIPSPPPRRC
       130        140        150        160        170        180
AHQAVVVPQG GGQLWVFGGE FASPNGEQFY HYKDLWVLHL ATKTWEQVKS TGGPSGRSGH
       190        200        210        220        230        240
RMVAWKRQLI LFGGFHESTR DYIYYNDVYA FNLDTFTWSK LSPSGTGPTP RSGCQMSVTP
       250        260        270        280        290        300
QGGIVVYGGY SKQRVKKDVD KGTRHSDMFL LKPEDGREDK WVWTRMNPSG VKPTPRSGFS
       310        320        330        340        350        360
VAMAPNHQTL FFGGVCDEEE EESLSGEFFN DLYFYDATRN RWFEGQLKGP KSEKKKRRRG
       370        380        390        400        410        420
RKEEPEGGSR PACGGAGTQG PVQLVKEVVA EDGTVVTIKQ VLTAPGSAGQ PRSEDEDSLE
       430        440        450        460        470        480
EAGSPAPGPC PRSNAMLAVK HGVLYVYGGM FEAGDRQVTL SDLHCLDLHR MEAWKALVEM
       490        500        510        520
DPETQEWLEE TDSEEDSEEV EGAEGGVDDE DSGEESGAED

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8TBB5-1-unknown	MGKKGK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8TBB5-1-unknown	MGKKGK...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79063
Q8TBB5-1-unknown	MGKKGK...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79064
Q8TBB5-2-unknown	GKKGKK...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8TBB5-2-unknown	GKKGKK...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8TBB5-2-unknown	GKKGKK...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162683
Q8TBB5-2-unknown	GKKGKK...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162684
Q8TBB5-400-unknown	QVLTAP...	400		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q8TBB5-400-unknown	QVLTAP...	400	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159857
Q8TBB5-400-unknown	QVLTAP...	400	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159856
Q8TBB5-400-	QVLTAP...	400		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SGAED	520	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SGAED	520	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74681
...SGAED	520	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt74682

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)