Q8TD55: Pleckstrin homology domain-containing family O member 2

General Information

Protein names	- Pleckstrin homology domain-containing family O member 2 - PH domain-containing family O member 2 - Pleckstrin homology domain-containing family Q member 1 - PH domain-containing family Q member 1
Gene names	PLEKHO2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8TD55

4 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEEEGVKEAG EKPRGAQMVD KAGWIKKSSG GLLGFWKDRY LLLCQAQLLV YENEDDQKCV
        70         80         90        100        110        120
ETVELGSYEK CQDLRALLKR KHRFILLRSP GNKVSDIKFQ APTGEEKESW IKALNEGINR
       130        140        150        160        170        180
GKNKAFDEVK VDKSCALEHV TRDRVRGGQR RRPPTRVHLK EVASAASDGL LRLDLDVPDS
       190        200        210        220        230        240
GPPVFAPSNH VSEAQPRETP RPLMPPTKPF LAPETTSPGD RVETPVGERA PTPVSASSEV
       250        260        270        280        290        300
SPESQEDSET PAEEDSGSEQ PPNSVLPDKL KVSWENPSPQ EAPAAESAEP SQAPCSETSE
       310        320        330        340        350        360
AAPREGGKPP TPPPKILSEK LKASMGEMQA SGPPAPGTVQ VSVNGMDDSP EPAKPSQAEG
       370        380        390        400        410        420
TPGTPPKDAT TSTALPPWDL PPQFHPRCSS LGDLLGEGPR HPLQPRERLY RAQLEVKVAS
       430        440        450        460        470        480
EQTEKLLNKV LGSEPAPVSA ETLLSQAVEQ LRQATQVLQE MRDLGELSQE APGLREKRKE
       490
LVTLYRRSAP

Isoforms

- Isoform 2 of Pleckstrin homology domain-containing family O member 2

Sequence View

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Evidence Codes:

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Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8TD55-1-acetylation	MEEEGV...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q8TD55-1-acetylation	MEEEGV...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q8TD55-1-unknown	MEEEGV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8TD55-180-unknown	SGPPVF...	180		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168119
Q8TD55-180-	SGPPVF...	180			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q8TD55-180-	SGPPVF...	180			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q8TD55-180-	SGPPVF...	180			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...RRSAP	490	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...RRSAP	490	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt81049

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)