Q8TDF6: RAS guanyl-releasing protein 4

General Information

Protein names	- RAS guanyl-releasing protein 4
Gene names	RASGRP4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8TDF6

1 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of RAS guanyl-releasing protein 4 - Isoform 3 of RAS guanyl-releasing protein 4 - Isoform 4 of RAS guanyl-releasing protein 4 - Isoform 5 of RAS guanyl-releasing protein 4 - Isoform 6 of RAS guanyl-releasing protein 4 - Isoform 7 of RAS guanyl-releasing protein 4 - Isoform 8 of RAS guanyl-releasing protein 4

Sequence View

        10         20         30         40         50         60
MNRKDSKRKS HQECTGKIGG RGRPRQVRRH KTCPSPREIS KVMASMNLGL LSEGGCSEDE
        70         80         90        100        110        120
LLEKCIQSFD SAGSLCHEDH MLNMVLAMHS WVLPSADLAA RLLTSYQKAT GDTQELRRLQ
       130        140        150        160        170        180
ICHLVRYWLM RHPEVMHQDP QLEEVIGRFW ATVAREGNSA QRRLGDSSDL LSPGGPGPPL
       190        200        210        220        230        240
PMSSPGLGKK RKVSLLFDHL ETGELAQHLT YLEFRSFQAI TPQDLRSYVL QGSVRGCPAL
       250        260        270        280        290        300
EGSVGLSNSV SRWVQVMVLS RPGPLQRAQV LDKFIHVAQR LHQLQNFNTL MAVTGGLCHS
       310        320        330        340        350        360
AISRLKDSHA HLSPDSTKAL LELTELLASH NNYARYRRTW AGCAGFRLPV LGVHLKDLVS
       370        380        390        400        410        420
LHEAQPDRLP DGRLHLPKLN NLYLRLQELV ALQGQHPPCS ANEDLLHLLT LSLDLFYTED
       430        440        450        460        470        480
EIYELSYARE PRCPKSLPPS PFNAPLVVEW APGVTPKPDR VTLGRHVEQL VESVFKNYDP
       490        500        510        520        530        540
EGRGTISQED FERLSGNFPF ACHGLHPPPR QGRGSFSREE LTGYLLRASA ICSKLGLAFL
       550        560        570        580        590        600
HTFHEVTFRK PTFCDSCSGF LWGVTKQGYR CRECGLCCHK HCRDQVKVEC KKRPGAKGDA
       610        620        630        640        650        660
GPPGAPVPST PAPHASCGSE ENHSYTLSLE PETGCQLRHA WTQTESPHPS WETDTVPCPV
       670
MDPPSTASSK LDS         10         20         30         40         50         60
MNRKDSKRKS HQECTGKIGG RGRPRQVRRH KTCPSPREIS KVMASMNLGL LSEGGCSEDE
        70         80         90        100        110        120
LLEKCIQSFD SAGSLCHEDH MLNMVLAMHS WVLPSADLAA RLLTSYQKAT GDTQELRRLQ
       130        140        150        160        170        180
ICHLVRYWLM RHPEVMHQDP QLEEVIGRFW ATVAREGNSA QRRLGDSSDL LSPGGPGPPL
       190        200        210        220        230        240
PMSSPGLGKK RKVSLLFDHL ETGELAQHLT YLEFRSFQAI TPQDLRSYVL QGSVRGCPAL
       250        260        270        280        290        300
EGSVGLSNSV SRWVQVMVLS RPGPLQRAQV LDKFIHVAQR LHQLQNFNTL MAVTGGLCHS
       310        320        330        340        350        360
AISRLKDSHA HLSPDSTKAL LELTELLASH NNYARYRRTW AGCAGFRLPV LGVHLKDLVS
       370        380        390        400        410        420
LHEAQPDRLP DGRLHLPKLN NLYLRLQELV ALQGQHPPCS ANEDLLHLLT LSLDLFYTED
       430        440        450        460        470        480
EIYELSYARE PRCPKSLPPS PFNAPLVVEW APGVTPKPDR VTLGRHVEQL VESVFKNYDP
       490        500        510        520        530        540
EGRGTISQED FERLSGNFPF ACHGLHPPPR QGRGSFSREE LTGYLLRASA ICSKLGLAFL
       550        560        570        580        590        600
HTFHEVTFRK PTFCDSCSGF LWGVTKQGYR CRECGLCCHK HCRDQVKVEC KKRPGAKGDA
       610        620        630        640        650        660
GPPGAPVPST PAPHASCGSE ENHSYTLSLE PETGCQLRHA WTQTESPHPS WETDTVPCPV
       670
MDPPSTASSK LDS         10         20         30         40         50         60
MNRKDSKRKS HQECTGKIGG RGRPRQVRRH KTCPSPREIS KVMASMNLGL LSEGGCSEDE
        70         80         90        100        110        120
LLEKCIQSFD SAGSLCHEDH MLNMVLAMHS WVLPSADLAA RLLTSYQKAT GDTQELRRLQ
       130        140        150        160        170        180
ICHLVRYWLM RHPEVMHQDP QLEEVIGRFW ATVAREGNSA QRRLGDSSDL LSPGGPGPPL
       190        200        210        220        230        240
PMSSPGLGKK RKVSLLFDHL ETGELAQHLT YLEFRSFQAI TPQDLRSYVL QGSVRGCPAL
       250        260        270        280        290        300
EGSVGLSNSV SRWVQVMVLS RPGPLQRAQV LDKFIHVAQR LHQLQNFNTL MAVTGGLCHS
       310        320        330        340        350        360
AISRLKDSHA HLSPDSTKAL LELTELLASH NNYARYRRTW AGCAGFRLPV LGVHLKDLVS
       370        380        390        400        410        420
LHEAQPDRLP DGRLHLPKLN NLYLRLQELV ALQGQHPPCS ANEDLLHLLT LSLDLFYTED
       430        440        450        460        470        480
EIYELSYARE PRCPKSLPPS PFNAPLVVEW APGVTPKPDR VTLGRHVEQL VESVFKNYDP
       490        500        510        520        530        540
EGRGTISQED FERLSGNFPF ACHGLHPPPR QGRGSFSREE LTGYLLRASA ICSKLGLAFL
       550        560        570        580        590        600
HTFHEVTFRK PTFCDSCSGF LWGVTKQGYR CRECGLCCHK HCRDQVKVEC KKRPGAKGDA
       610        620        630        640        650        660
GPPGAPVPST PAPHASCGSE ENHSYTLSLE PETGCQLRHA WTQTESPHPS WETDTVPCPV
       670
MDPPSTASSK LDS         10         20         30         40         50         60
MNRKDSKRKS HQECTGKIGG RGRPRQVRRH KTCPSPREIS KVMASMNLGL LSEGGCSEDE
        70         80         90        100        110        120
LLEKCIQSFD SAGSLCHEDH MLNMVLAMHS WVLPSADLAA RLLTSYQKAT GDTQELRRLQ
       130        140        150        160        170        180
ICHLVRYWLM RHPEVMHQDP QLEEVIGRFW ATVAREGNSA QRRLGDSSDL LSPGGPGPPL
       190        200        210        220        230        240
PMSSPGLGKK RKVSLLFDHL ETGELAQHLT YLEFRSFQAI TPQDLRSYVL QGSVRGCPAL
       250        260        270        280        290        300
EGSVGLSNSV SRWVQVMVLS RPGPLQRAQV LDKFIHVAQR LHQLQNFNTL MAVTGGLCHS
       310        320        330        340        350        360
AISRLKDSHA HLSPDSTKAL LELTELLASH NNYARYRRTW AGCAGFRLPV LGVHLKDLVS
       370        380        390        400        410        420
LHEAQPDRLP DGRLHLPKLN NLYLRLQELV ALQGQHPPCS ANEDLLHLLT LSLDLFYTED
       430        440        450        460        470        480
EIYELSYARE PRCPKSLPPS PFNAPLVVEW APGVTPKPDR VTLGRHVEQL VESVFKNYDP
       490        500        510        520        530        540
EGRGTISQED FERLSGNFPF ACHGLHPPPR QGRGSFSREE LTGYLLRASA ICSKLGLAFL
       550        560        570        580        590        600
HTFHEVTFRK PTFCDSCSGF LWGVTKQGYR CRECGLCCHK HCRDQVKVEC KKRPGAKGDA
       610        620        630        640        650        660
GPPGAPVPST PAPHASCGSE ENHSYTLSLE PETGCQLRHA WTQTESPHPS WETDTVPCPV
       670
MDPPSTASSK LDS         10         20         30         40         50         60
MNRKDSKRKS HQECTGKIGG RGRPRQVRRH KTCPSPREIS KVMASMNLGL LSEGGCSEDE
        70         80         90        100        110        120
LLEKCIQSFD SAGSLCHEDH MLNMVLAMHS WVLPSADLAA RLLTSYQKAT GDTQELRRLQ
       130        140        150        160        170        180
ICHLVRYWLM RHPEVMHQDP QLEEVIGRFW ATVAREGNSA QRRLGDSSDL LSPGGPGPPL
       190        200        210        220        230        240
PMSSPGLGKK RKVSLLFDHL ETGELAQHLT YLEFRSFQAI TPQDLRSYVL QGSVRGCPAL
       250        260        270        280        290        300
EGSVGLSNSV SRWVQVMVLS RPGPLQRAQV LDKFIHVAQR LHQLQNFNTL MAVTGGLCHS
       310        320        330        340        350        360
AISRLKDSHA HLSPDSTKAL LELTELLASH NNYARYRRTW AGCAGFRLPV LGVHLKDLVS
       370        380        390        400        410        420
LHEAQPDRLP DGRLHLPKLN NLYLRLQELV ALQGQHPPCS ANEDLLHLLT LSLDLFYTED
       430        440        450        460        470        480
EIYELSYARE PRCPKSLPPS PFNAPLVVEW APGVTPKPDR VTLGRHVEQL VESVFKNYDP
       490        500        510        520        530        540
EGRGTISQED FERLSGNFPF ACHGLHPPPR QGRGSFSREE LTGYLLRASA ICSKLGLAFL
       550        560        570        580        590        600
HTFHEVTFRK PTFCDSCSGF LWGVTKQGYR CRECGLCCHK HCRDQVKVEC KKRPGAKGDA
       610        620        630        640        650        660
GPPGAPVPST PAPHASCGSE ENHSYTLSLE PETGCQLRHA WTQTESPHPS WETDTVPCPV
       670
MDPPSTASSK LDS         10         20         30         40         50         60
MNRKDSKRKS HQECTGKIGG RGRPRQVRRH KTCPSPREIS KVMASMNLGL LSEGGCSEDE
        70         80         90        100        110        120
LLEKCIQSFD SAGSLCHEDH MLNMVLAMHS WVLPSADLAA RLLTSYQKAT GDTQELRRLQ
       130        140        150        160        170        180
ICHLVRYWLM RHPEVMHQDP QLEEVIGRFW ATVAREGNSA QRRLGDSSDL LSPGGPGPPL
       190        200        210        220        230        240
PMSSPGLGKK RKVSLLFDHL ETGELAQHLT YLEFRSFQAI TPQDLRSYVL QGSVRGCPAL
       250        260        270        280        290        300
EGSVGLSNSV SRWVQVMVLS RPGPLQRAQV LDKFIHVAQR LHQLQNFNTL MAVTGGLCHS
       310        320        330        340        350        360
AISRLKDSHA HLSPDSTKAL LELTELLASH NNYARYRRTW AGCAGFRLPV LGVHLKDLVS
       370        380        390        400        410        420
LHEAQPDRLP DGRLHLPKLN NLYLRLQELV ALQGQHPPCS ANEDLLHLLT LSLDLFYTED
       430        440        450        460        470        480
EIYELSYARE PRCPKSLPPS PFNAPLVVEW APGVTPKPDR VTLGRHVEQL VESVFKNYDP
       490        500        510        520        530        540
EGRGTISQED FERLSGNFPF ACHGLHPPPR QGRGSFSREE LTGYLLRASA ICSKLGLAFL
       550        560        570        580        590        600
HTFHEVTFRK PTFCDSCSGF LWGVTKQGYR CRECGLCCHK HCRDQVKVEC KKRPGAKGDA
       610        620        630        640        650        660
GPPGAPVPST PAPHASCGSE ENHSYTLSLE PETGCQLRHA WTQTESPHPS WETDTVPCPV
       670
MDPPSTASSK LDS         10         20         30         40         50         60
MNRKDSKRKS HQECTGKIGG RGRPRQVRRH KTCPSPREIS KVMASMNLGL LSEGGCSEDE
        70         80         90        100        110        120
LLEKCIQSFD SAGSLCHEDH MLNMVLAMHS WVLPSADLAA RLLTSYQKAT GDTQELRRLQ
       130        140        150        160        170        180
ICHLVRYWLM RHPEVMHQDP QLEEVIGRFW ATVAREGNSA QRRLGDSSDL LSPGGPGPPL
       190        200        210        220        230        240
PMSSPGLGKK RKVSLLFDHL ETGELAQHLT YLEFRSFQAI TPQDLRSYVL QGSVRGCPAL
       250        260        270        280        290        300
EGSVGLSNSV SRWVQVMVLS RPGPLQRAQV LDKFIHVAQR LHQLQNFNTL MAVTGGLCHS
       310        320        330        340        350        360
AISRLKDSHA HLSPDSTKAL LELTELLASH NNYARYRRTW AGCAGFRLPV LGVHLKDLVS
       370        380        390        400        410        420
LHEAQPDRLP DGRLHLPKLN NLYLRLQELV ALQGQHPPCS ANEDLLHLLT LSLDLFYTED
       430        440        450        460        470        480
EIYELSYARE PRCPKSLPPS PFNAPLVVEW APGVTPKPDR VTLGRHVEQL VESVFKNYDP
       490        500        510        520        530        540
EGRGTISQED FERLSGNFPF ACHGLHPPPR QGRGSFSREE LTGYLLRASA ICSKLGLAFL
       550        560        570        580        590        600
HTFHEVTFRK PTFCDSCSGF LWGVTKQGYR CRECGLCCHK HCRDQVKVEC KKRPGAKGDA
       610        620        630        640        650        660
GPPGAPVPST PAPHASCGSE ENHSYTLSLE PETGCQLRHA WTQTESPHPS WETDTVPCPV
       670
MDPPSTASSK LDS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

1 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q8TDF6-1-unknown	MNRKDS...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8TDF6-1-unknown	MNRKDS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76517
Q8TDF6-1-unknown	MNRKDS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76518
Q8TDF6-1-unknown	MNRKDS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76519
Q8TDF6-1-unknown	MNRKDS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76520
Q8TDF6-1-unknown	MNRKDS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76521
Q8TDF6-1-unknown	MNRKDS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76522
Q8TDF6-1-unknown	MNRKDS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76523

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DSSDLL	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72136
...DSSDLL	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91791
...DSSDLL	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91792
...DSSDLL	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91793
...DSSDLL	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91794
...DSSDLL	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91795
...DSSDLL	170	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91796
...SKLDS	673	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SKLDS	673	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72138
...SKLDS	673	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72139
...SKLDS	673	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72137
...SKLDS	673	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72141
...SKLDS	673	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72140
...SKLDS	673	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72135

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)