Q8VHX6: Filamin-C

General Information

Protein names	- Filamin-C - FLN-C - ABP-280-like protein - ABP-L - Actin-binding-like protein - Filamin-2 - Gamma-filamin
Gene names	Flnc
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8VHX6

4 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MMNNSNYSDA SGLGLVDEAD EMPSTEKDLA EDAPWKKIQQ NTFTRWCNEH LKCVGKRLTD
        70         80         90        100        110        120
LQRDLSDGLR LIALLEVLSQ KRMYRKFHPR PNFRQMKLEN VSVALEFLER EHIKLVSIDS
       130        140        150        160        170        180
KAIVDGNLKL ILGLIWTLIL HYSISMPMWE DEDDEDARKQ TPKQRLLGWI QNKVPQLPIT
       190        200        210        220        230        240
NFNRDWQDGK ALGALVDNCA PGLCPDWEAW DPNQPVQNAR EAMQQADDWL GVPQVIAPEE
       250        260        270        280        290        300
IVDPNVDEHS VMTYLSQFPK AKLKPGAPVR SKQLNPKKAI AYGPGIEPQG NTVLQPAHFT
       310        320        330        340        350        360
VQTVDAGVGE VLVYIEDPEG HTEEAKVVPN NDKDRTYAVS YVPKVAGLHK VTVLFAGQNI
       370        380        390        400        410        420
ERSPFEVNVG MALGDANKVS ARGPGLEPVG NVANKPTYFD IYTAGAGTGD VAVVIVDPQG
       430        440        450        460        470        480
RRDTVEVALE DKGDNTFRCT YRPVMEGPHT VHVAFAGAPI TRSPFPVHVA EACNPNACRA
       490        500        510        520        530        540
SGRGLQPKGV RVKEVADFKV FTKGAGSGEL KVTVKGPKGT EEPVKVREAG DGVFECEYYP
       550        560        570        580        590        600
VVPGKYVVTI TWGGYAIPRS PFEVQVSPEA GAQKVRAWGP GLETGQVGKS ADFVVEAIGT
       610        620        630        640        650        660
EVGTLGFSIE GPSQAKIECD DKGDGSCDVR YWPTEPGEYA VHVICDDEDI RDSPFIAHIQ
       670        680        690        700        710        720
PAPPDCFPDK VKAFGPGLEP TGCIVDRPAE FTIDARAAGK GDLKLYAQDA DGCPIDIKVI
       730        740        750        760        770        780
PNGDGTFRCS YVPTKPIKHT IIVSWGGVNV PKSPFRVNVG EGSHPERVKV YGPGVEKTGL
       790        800        810        820        830        840
KANEPTYFTV DCSEAGQGDV SIGIKCAPGV VGPVEADIDF DIIKNDNDTF TVKYTPPGAG
       850        860        870        880        890        900
HYTIMVLFAN QEIPASPFHI KVDPSHDASK VKAEGPGLSR TGVEVGKPTH FTVLTKGAGK
       910        920        930        940        950        960
AKLDVHFAGA AKGEAVRDFE IIDNHDYSYT VKYTAVQQGN MAVTVTYGGD PVPKSPFVVN
       970        980        990       1000       1010       1020
VAPPLDLSKV KVQGLNSKVA VGQEQAFSVN TRGAGGQGQL DVRMTSPSRR PIPCKLEPGG
      1030       1040       1050       1060       1070       1080
GAEAQAVRYM PPEEGPYKVD ITYDGHPVPG SPFAVEGVLP PDPSKVCAYG PGLKGGLVGT
      1090       1100       1110       1120       1130       1140
PAPFSIDTKG AGTGGLGLTV EGPCEAKIEC QDNGDGSCAV SYLPTEPGEY TINILFAEAH
      1150       1160       1170       1180       1190       1200
IPGSPFKATI QPVFDPSKVR ASGPGLERGK AGEAATFTVD CSEAGEAELT IEILSDAGVK
      1210       1220       1230       1240       1250       1260
AEVLIQNNAD GTYHITYSPA FPGTYTITIK YGGHPIPKFP TRVHVQPAVD TSGIKVSGPG
      1270       1280       1290       1300       1310       1320
VEPHGVLREV TTEFTVDARS LTATGGNHVT ARVLNPSGAK TDTYVTDNGD GTYRVQYTAY
      1330       1340       1350       1360       1370       1380
EEGVHLVEVL YDEVAVPKSP FRVGVTEGCD PTRVRAFGPG LEGGLVNKAN RFTVETRGAG
      1390       1400       1410       1420       1430       1440
TGGLGLAIEG PSEAKMSCKD NKDGSCTVEY IPFTPGDYDV NITFGGQPIP GSPFRVPVKD
      1450       1460       1470       1480       1490       1500
VVDPGKVKCS GPGLGTGVRA RVPQTFTVDC SQAGRAPLQV AVLGPTGVAE PVEVRDNGDG
      1510       1520       1530       1540       1550       1560
THTVHYTPAT DGPYTVAVKY ADQEVPRSPF KIKVLPSHDA SKVRASGPGL NASGIPASLP
      1570       1580       1590       1600       1610       1620
VEFTIDARDA GQGLLTVQIL DPEGKPKKAN IRDNGDGTYT VSYLPDMSGR YTITIKYGGD
      1630       1640       1650       1660       1670       1680
EIPYSPFRIH ALPTGDASKC LVTVSIGGHG LGACLGPRIQ IGEETVITVD AKAAGKGKVT
      1690       1700       1710       1720       1730       1740
CTVSTPDGAE LDVDVVENHD GTFDIYYTAP EPGKYVITIR FGGEHIPNSP FHVLACDPLP
      1750       1760       1770       1780       1790       1800
HVEEPAEMLQ MRQPYAPLRP GTCPTHWATE EPVVPVEPLE SMLRPFNLVI PFTVQKGELT
      1810       1820       1830       1840       1850       1860
GEVRMPSGKT ARPNITDNKD GTITVRYAPT EKGLHQMGIK YDGNHIPGSP LQFYVDAINS
      1870       1880       1890       1900       1910       1920
RHVSAYGPGL SHGMVNKPAT FTIVTKDAGE GGLSLAVEGP SKAEITCKDN KDGTCTVSYL
      1930       1940       1950       1960       1970       1980
PTAPGDYSII VRFDDKHIPG SPFTAKITGD DSMRTSQLNV GTSTDVSLKI TEGDLSQLTA
      1990       2000       2010       2020       2030       2040
SIRAPSGNEE PCLLKRLPNR HIGISFTPKE VGEHVVSVRK SGKHVTNSPF KILVGPSEIG
      2050       2060       2070       2080       2090       2100
DASKVRVWGK GLSEGQTFQV AEFIVDTRNA GYGGLGLSIE GPSKVDINCE DMEDGTCKVT
      2110       2120       2130       2140       2150       2160
YCPTEPGTYI INIKFADKHV PGSPFTVKVT GEGRMKESIT RRRQAPSIAT IGSTCDLNLK
      2170       2180       2190       2200       2210       2220
IPGNWFQMVS AQERLTRTFT RSSHTYTRTE RTEISKTRGG ETKREVRVEE STQVGGDPFP
      2230       2240       2250       2260       2270       2280
AVFGDFLGRE RLGSFGSITR QQEGEASSQD MTAQVTSPSG KTEAAEIVEG EDSAYSVRFV
      2290       2300       2310       2320       2330       2340
PQEMGPHTVT VKYRGQHVPG SPFQFTVGPL GEGGAHKVRA GGTGLERGVA GVPAEFSIWT
      2350       2360       2370       2380       2390       2400
REAGAGGLSI AVEGPSKAEI AFEDRKDGSC GVSYVVQEPG DYEVSIKFND EHIPDSPFVV
      2410       2420       2430       2440       2450       2460
PVASLSDDAR RLTVTSLQET GLKVNQPASF AVQLNGARGV IDARVHTPSG AVEECYVSEL
      2470       2480       2490       2500       2510       2520
DSDKHTIRFI PHENGVHSID VKFNGAHIPG SPFKIRVGEQ SQAGDPGLVS AYGPGLEGGT
      2530       2540       2550       2560       2570       2580
TGVSSEFIVN TQNAGSGALS VTIDGPSKVQ LDCRECPEGH VVTYTPMAPG NYLIAIKYGG
      2590       2600       2610       2620       2630       2640
PQHIVGSPFK AKVTGPRLSG GHSLHETSTV LVETVTKSSS SRGASYSSIP KFSSDASKVV
      2650       2660       2670       2680       2690       2700
TRGPGLSQAF VGQKNSFTVD CSKAGTNMMM VGVHGPKTPC EEVYVKHMGN RVYNVTYTVK
      2710       2720
EKGDYILIVK WGDESVPGSP FKVNVP

Isoforms

- Isoform 2 of Filamin-C

Sequence View

        10         20         30         40         50         60
MMNNSNYSDA SGLGLVDEAD EMPSTEKDLA EDAPWKKIQQ NTFTRWCNEH LKCVGKRLTD
        70         80         90        100        110        120
LQRDLSDGLR LIALLEVLSQ KRMYRKFHPR PNFRQMKLEN VSVALEFLER EHIKLVSIDS
       130        140        150        160        170        180
KAIVDGNLKL ILGLIWTLIL HYSISMPMWE DEDDEDARKQ TPKQRLLGWI QNKVPQLPIT
       190        200        210        220        230        240
NFNRDWQDGK ALGALVDNCA PGLCPDWEAW DPNQPVQNAR EAMQQADDWL GVPQVIAPEE
       250        260        270        280        290        300
IVDPNVDEHS VMTYLSQFPK AKLKPGAPVR SKQLNPKKAI AYGPGIEPQG NTVLQPAHFT
       310        320        330        340        350        360
VQTVDAGVGE VLVYIEDPEG HTEEAKVVPN NDKDRTYAVS YVPKVAGLHK VTVLFAGQNI
       370        380        390        400        410        420
ERSPFEVNVG MALGDANKVS ARGPGLEPVG NVANKPTYFD IYTAGAGTGD VAVVIVDPQG
       430        440        450        460        470        480
RRDTVEVALE DKGDNTFRCT YRPVMEGPHT VHVAFAGAPI TRSPFPVHVA EACNPNACRA
       490        500        510        520        530        540
SGRGLQPKGV RVKEVADFKV FTKGAGSGEL KVTVKGPKGT EEPVKVREAG DGVFECEYYP
       550        560        570        580        590        600
VVPGKYVVTI TWGGYAIPRS PFEVQVSPEA GAQKVRAWGP GLETGQVGKS ADFVVEAIGT
       610        620        630        640        650        660
EVGTLGFSIE GPSQAKIECD DKGDGSCDVR YWPTEPGEYA VHVICDDEDI RDSPFIAHIQ
       670        680        690        700        710        720
PAPPDCFPDK VKAFGPGLEP TGCIVDRPAE FTIDARAAGK GDLKLYAQDA DGCPIDIKVI
       730        740        750        760        770        780
PNGDGTFRCS YVPTKPIKHT IIVSWGGVNV PKSPFRVNVG EGSHPERVKV YGPGVEKTGL
       790        800        810        820        830        840
KANEPTYFTV DCSEAGQGDV SIGIKCAPGV VGPVEADIDF DIIKNDNDTF TVKYTPPGAG
       850        860        870        880        890        900
HYTIMVLFAN QEIPASPFHI KVDPSHDASK VKAEGPGLSR TGVEVGKPTH FTVLTKGAGK
       910        920        930        940        950        960
AKLDVHFAGA AKGEAVRDFE IIDNHDYSYT VKYTAVQQGN MAVTVTYGGD PVPKSPFVVN
       970        980        990       1000       1010       1020
VAPPLDLSKV KVQGLNSKVA VGQEQAFSVN TRGAGGQGQL DVRMTSPSRR PIPCKLEPGG
      1030       1040       1050       1060       1070       1080
GAEAQAVRYM PPEEGPYKVD ITYDGHPVPG SPFAVEGVLP PDPSKVCAYG PGLKGGLVGT
      1090       1100       1110       1120       1130       1140
PAPFSIDTKG AGTGGLGLTV EGPCEAKIEC QDNGDGSCAV SYLPTEPGEY TINILFAEAH
      1150       1160       1170       1180       1190       1200
IPGSPFKATI QPVFDPSKVR ASGPGLERGK AGEAATFTVD CSEAGEAELT IEILSDAGVK
      1210       1220       1230       1240       1250       1260
AEVLIQNNAD GTYHITYSPA FPGTYTITIK YGGHPIPKFP TRVHVQPAVD TSGIKVSGPG
      1270       1280       1290       1300       1310       1320
VEPHGVLREV TTEFTVDARS LTATGGNHVT ARVLNPSGAK TDTYVTDNGD GTYRVQYTAY
      1330       1340       1350       1360       1370       1380
EEGVHLVEVL YDEVAVPKSP FRVGVTEGCD PTRVRAFGPG LEGGLVNKAN RFTVETRGAG
      1390       1400       1410       1420       1430       1440
TGGLGLAIEG PSEAKMSCKD NKDGSCTVEY IPFTPGDYDV NITFGGQPIP GSPFRVPVKD
      1450       1460       1470       1480       1490       1500
VVDPGKVKCS GPGLGTGVRA RVPQTFTVDC SQAGRAPLQV AVLGPTGVAE PVEVRDNGDG
      1510       1520       1530       1540       1550       1560
THTVHYTPAT DGPYTVAVKY ADQEVPRSPF KIKVLPSHDA SKVRASGPGL NASGIPASLP
      1570       1580       1590       1600       1610       1620
VEFTIDARDA GQGLLTVQIL DPEGKPKKAN IRDNGDGTYT VSYLPDMSGR YTITIKYGGD
      1630       1640       1650       1660       1670       1680
EIPYSPFRIH ALPTGDASKC LVTVSIGGHG LGACLGPRIQ IGEETVITVD AKAAGKGKVT
      1690       1700       1710       1720       1730       1740
CTVSTPDGAE LDVDVVENHD GTFDIYYTAP EPGKYVITIR FGGEHIPNSP FHVLACDPLP
      1750       1760       1770       1780       1790       1800
HVEEPAEMLQ MRQPYAPLRP GTCPTHWATE EPVVPVEPLE SMLRPFNLVI PFTVQKGELT
      1810       1820       1830       1840       1850       1860
GEVRMPSGKT ARPNITDNKD GTITVRYAPT EKGLHQMGIK YDGNHIPGSP LQFYVDAINS
      1870       1880       1890       1900       1910       1920
RHVSAYGPGL SHGMVNKPAT FTIVTKDAGE GGLSLAVEGP SKAEITCKDN KDGTCTVSYL
      1930       1940       1950       1960       1970       1980
PTAPGDYSII VRFDDKHIPG SPFTAKITGD DSMRTSQLNV GTSTDVSLKI TEGDLSQLTA
      1990       2000       2010       2020       2030       2040
SIRAPSGNEE PCLLKRLPNR HIGISFTPKE VGEHVVSVRK SGKHVTNSPF KILVGPSEIG
      2050       2060       2070       2080       2090       2100
DASKVRVWGK GLSEGQTFQV AEFIVDTRNA GYGGLGLSIE GPSKVDINCE DMEDGTCKVT
      2110       2120       2130       2140       2150       2160
YCPTEPGTYI INIKFADKHV PGSPFTVKVT GEGRMKESIT RRRQAPSIAT IGSTCDLNLK
      2170       2180       2190       2200       2210       2220
IPGNWFQMVS AQERLTRTFT RSSHTYTRTE RTEISKTRGG ETKREVRVEE STQVGGDPFP
      2230       2240       2250       2260       2270       2280
AVFGDFLGRE RLGSFGSITR QQEGEASSQD MTAQVTSPSG KTEAAEIVEG EDSAYSVRFV
      2290       2300       2310       2320       2330       2340
PQEMGPHTVT VKYRGQHVPG SPFQFTVGPL GEGGAHKVRA GGTGLERGVA GVPAEFSIWT
      2350       2360       2370       2380       2390       2400
REAGAGGLSI AVEGPSKAEI AFEDRKDGSC GVSYVVQEPG DYEVSIKFND EHIPDSPFVV
      2410       2420       2430       2440       2450       2460
PVASLSDDAR RLTVTSLQET GLKVNQPASF AVQLNGARGV IDARVHTPSG AVEECYVSEL
      2470       2480       2490       2500       2510       2520
DSDKHTIRFI PHENGVHSID VKFNGAHIPG SPFKIRVGEQ SQAGDPGLVS AYGPGLEGGT
      2530       2540       2550       2560       2570       2580
TGVSSEFIVN TQNAGSGALS VTIDGPSKVQ LDCRECPEGH VVTYTPMAPG NYLIAIKYGG
      2590       2600       2610       2620       2630       2640
PQHIVGSPFK AKVTGPRLSG GHSLHETSTV LVETVTKSSS SRGASYSSIP KFSSDASKVV
      2650       2660       2670       2680       2690       2700
TRGPGLSQAF VGQKNSFTVD CSKAGTNMMM VGVHGPKTPC EEVYVKHMGN RVYNVTYTVK
      2710       2720
EKGDYILIVK WGDESVPGSP FKVNVP

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q8VHX6-1-unknown	MMNNSN...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8VHX6-1-unknown	MMNNSN...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt75266
Q8VHX6-227-unknown	DDWLGV...	227	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q8VHX6-227-unknown	DDWLGV...	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt198301
Q8VHX6-1789-unknown	VIPFTV...	1789	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30869
Q8VHX6-1789-unknown	VIPFTV...	1789	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt158498
Q8VHX6-1854-unknown	YVDAIN...	1854	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30871
Q8VHX6-1854-unknown	YVDAIN...	1854	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt158579

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RPFNLV	1788	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30869
...RPFNLV	1788	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt142002
...SPLQFY	1853	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30871
...SPLQFY	1853	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt142083
...KVNVP	2726	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KVNVP	2726	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70884

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	1788	FNLV.\|.VIPF	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> FLNC_MOUSE @1788
CATE_MOUSE	1853	LQFY.\|.YVDA	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> FLNC_MOUSE @1853

TopFIND

Q8VHX6: Filamin-C

General Information

4

N-termini

3

C-termini

2

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates