TopFIND 4.0

Q8WW43: Gamma-secretase subunit APH-1B

General Information

Protein names
- Gamma-secretase subunit APH-1B
- APH-1b
- Aph-1beta
- Presenilin-stabilization factor-like
Gene names APH1B
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q8WW43

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MTAAVFFGCA FIAFGPALAL YVFTIATEPL RIIFLIAGAF FWLVSLLISS LVWFMARVII 
        70         80         90        100        110        120 
DNKDGPTQKY LLIFGAFVSV YIQEMFRFAY YKLLKKASEG LKSINPGETA PSMRLLAYVS 
       130        140        150        160        170        180 
GLGFGIMSGV FSFVNTLSDS LGPGTVGIHG DSPQFFLYSA FMTLVIILLH VFWGIVFFDG 
       190        200        210        220        230        240 
CEKKKWGILL IVLLTHLLVS AQTFISSYYG INLASAFIIL VLMGTWAFLA AGGSCRSLKL 
       250    
CLLCQDKNFL LYNQRSR

Isoforms

- Isoform 2 of Gamma-secretase subunit APH-1B

Sequence View

        10         20         30         40         50         60 
MTAAVFFGCA FIAFGPALAL YVFTIATEPL RIIFLIAGAF FWLVSLLISS LVWFMARVII 
        70         80         90        100        110        120 
DNKDGPTQKY LLIFGAFVSV YIQEMFRFAY YKLLKKASEG LKSINPGETA PSMRLLAYVS 
       130        140        150        160        170        180 
GLGFGIMSGV FSFVNTLSDS LGPGTVGIHG DSPQFFLYSA FMTLVIILLH VFWGIVFFDG 
       190        200        210        220        230        240 
CEKKKWGILL IVLLTHLLVS AQTFISSYYG INLASAFIIL VLMGTWAFLA AGGSCRSLKL 
       250    
CLLCQDKNFL LYNQRSR



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8WW43-1-unknown MTAAVF... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8WW43-1-unknown MTAAVF... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt67224

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...NQRSR 257 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...NQRSR 257 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt62842

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)