TopFIND 4.0

Q8WY64: E3 ubiquitin-protein ligase MYLIP

General Information

Protein names
- E3 ubiquitin-protein ligase MYLIP
- 2.3.2.27
- Inducible degrader of the LDL-receptor
- Idol
- Myosin regulatory light chain interacting protein
- MIR
- RING-type E3 ubiquitin transferase MYLIP {ECO:0000305}
Gene names MYLIP
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q8WY64

2

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MLCYVTRPDA VLMEVEVEAK ANGEDCLNQV CRRLGIIEVD YFGLQFTGSK GESLWLNLRN 
        70         80         90        100        110        120 
RISQQMDGLA PYRLKLRVKF FVEPHLILQE QTRHIFFLHI KEALLAGHLL CSPEQAVELS 
       130        140        150        160        170        180 
ALLAQTKFGD YNQNTAKYNY EELCAKELSS ATLNSIVAKH KELEGTSQAS AEYQVLQIVS 
       190        200        210        220        230        240 
AMENYGIEWH SVRDSEGQKL LIGVGPEGIS ICKDDFSPIN RIAYPVVQMA TQSGKNVYLT 
       250        260        270        280        290        300 
VTKESGNSIV LLFKMISTRA ASGLYRAITE THAFYRCDTV TSAVMMQYSR DLKGHLASLF 
       310        320        330        340        350        360 
LNENINLGKK YVFDIKRTSK EVYDHARRAL YNAGVVDLVS RNNQSPSHSP LKSSESSMNC 
       370        380        390        400        410        420 
SSCEGLSCQQ TRVLQEKLRK LKEAMLCMVC CEEEINSTFC PCGHTVCCES CAAQLQSCPV 
       430        440    
CRSRVEHVQH VYLPTHTSLL NLTVI

Isoforms

- Isoform 2 of E3 ubiquitin-protein ligase MYLIP

Sequence View

        10         20         30         40         50         60 
MLCYVTRPDA VLMEVEVEAK ANGEDCLNQV CRRLGIIEVD YFGLQFTGSK GESLWLNLRN 
        70         80         90        100        110        120 
RISQQMDGLA PYRLKLRVKF FVEPHLILQE QTRHIFFLHI KEALLAGHLL CSPEQAVELS 
       130        140        150        160        170        180 
ALLAQTKFGD YNQNTAKYNY EELCAKELSS ATLNSIVAKH KELEGTSQAS AEYQVLQIVS 
       190        200        210        220        230        240 
AMENYGIEWH SVRDSEGQKL LIGVGPEGIS ICKDDFSPIN RIAYPVVQMA TQSGKNVYLT 
       250        260        270        280        290        300 
VTKESGNSIV LLFKMISTRA ASGLYRAITE THAFYRCDTV TSAVMMQYSR DLKGHLASLF 
       310        320        330        340        350        360 
LNENINLGKK YVFDIKRTSK EVYDHARRAL YNAGVVDLVS RNNQSPSHSP LKSSESSMNC 
       370        380        390        400        410        420 
SSCEGLSCQQ TRVLQEKLRK LKEAMLCMVC CEEEINSTFC PCGHTVCCES CAAQLQSCPV 
       430        440    
CRSRVEHVQH VYLPTHTSLL NLTVI



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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8WY64-1-unknown MLCYVT... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8WY64-182-unknown MENYGI... 182 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt81976

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...YVFDIK 315 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt77594
    ...NLTVI 445 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)