TopFIND 4.0

Q8WYK0: Acetyl-coenzyme A thioesterase {ECO:0000305}

General Information

Protein names
- Acetyl-coenzyme A thioesterase {ECO:0000305}
- 3.1.2.1 {ECO:0000269|PubMed:16951743}
- Acyl-CoA thioester hydrolase 12
- Acyl-coenzyme A thioesterase 12
- Acyl-CoA thioesterase 12
- Cytoplasmic acetyl-CoA hydrolase 1
- CACH-1
- hCACH-1
- START domain-containing protein 15
- StARD15
Gene names ACOT12
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q8WYK0

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MERPAPGEVV MSQAIQPAHA TARGELSAGQ LLKWIDTTAC LAAEKHAGVS CVTASVDDIQ 
        70         80         90        100        110        120 
FEETARVGQV ITIKAKVTRA FSTSMEISIK VMVQDMLTGI EKLVSVAFST FVAKPVGKEK 
       130        140        150        160        170        180 
IHLKPVTLLT EQDHVEHNLA AERRKVRLQH EDTFNNLMKE SSKFDDLIFD EEEGAVSTRG 
       190        200        210        220        230        240 
TSVQSIELVL PPHANHHGNT FGGQIMAWME TVATISASRL CWAHPFLKSV DMFKFRGPST 
       250        260        270        280        290        300 
VGDRLVFTAI VNNTFQTCVE VGVRVEAFDC QEWAEGRGRH INSAFLIYNA ADDKENLITF 
       310        320        330        340        350        360 
PRIQPISKDD FRRYRGAIAR KRIRLGRKYV ISHKEEVPLC IHWDISKQAS LSDSNVEALK 
       370        380        390        400        410        420 
KLAAKRGWEV TSTVEKIKIY TLEEHDVLSV WVEKHVGSPA HLAYRLLSDF TKRPLWDPHF 
       430        440        450        460        470        480 
VSCEVIDWVS EDDQLYHITC PILNDDKPKD LVVLVSRRKP LKDGNTYTVA VKSVILPSVP 
       490        500        510        520        530        540 
PSPQYIRSEI ICAGFLIHAI DSNSCIVSYF NHMSASILPY FAGNLGGWSK SIEETAASCI 
       550    
QFLENPPDDG FVSTF

Isoforms

- Isoform 2 of Acetyl-coenzyme A thioesterase

Sequence View

        10         20         30         40         50         60 
MERPAPGEVV MSQAIQPAHA TARGELSAGQ LLKWIDTTAC LAAEKHAGVS CVTASVDDIQ 
        70         80         90        100        110        120 
FEETARVGQV ITIKAKVTRA FSTSMEISIK VMVQDMLTGI EKLVSVAFST FVAKPVGKEK 
       130        140        150        160        170        180 
IHLKPVTLLT EQDHVEHNLA AERRKVRLQH EDTFNNLMKE SSKFDDLIFD EEEGAVSTRG 
       190        200        210        220        230        240 
TSVQSIELVL PPHANHHGNT FGGQIMAWME TVATISASRL CWAHPFLKSV DMFKFRGPST 
       250        260        270        280        290        300 
VGDRLVFTAI VNNTFQTCVE VGVRVEAFDC QEWAEGRGRH INSAFLIYNA ADDKENLITF 
       310        320        330        340        350        360 
PRIQPISKDD FRRYRGAIAR KRIRLGRKYV ISHKEEVPLC IHWDISKQAS LSDSNVEALK 
       370        380        390        400        410        420 
KLAAKRGWEV TSTVEKIKIY TLEEHDVLSV WVEKHVGSPA HLAYRLLSDF TKRPLWDPHF 
       430        440        450        460        470        480 
VSCEVIDWVS EDDQLYHITC PILNDDKPKD LVVLVSRRKP LKDGNTYTVA VKSVILPSVP 
       490        500        510        520        530        540 
PSPQYIRSEI ICAGFLIHAI DSNSCIVSYF NHMSASILPY FAGNLGGWSK SIEETAASCI 
       550    
QFLENPPDDG FVSTF



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8WYK0-1-unknown MERPAP... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...FVSTF 555 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)